Cancer vaccination with telomerase peptide GV1001

• Published in: Expert opinion on investigational drugs Vol. 18; no. 5; p. 687
• Main Author: Kyte, Jon Amund
• Format: Journal Article
• Language: English
• Published: England 01.05.2009
• Subjects: Animals; Cancer Vaccines - administration & dosage; Clinical Trials as Topic - methods; Clinical Trials as Topic - trends; Humans; Neoplasms - enzymology; Neoplasms - prevention & control; Peptide Fragments - administration & dosage; Telomerase - administration & dosage

Telomerase is highly expressed in essentially all cancer forms, while the expression in normal tissues is restricted. Moreover, telomerase activity is considered indispensable for tumor immortalization and growth. Human telomerase reverse transcriptase (hTERT), the rate-limiting subunit of the telom...