Increased rates of brain protein synthesis during [N1,N2] sleep: L-[1-11C]leucine PET studies in human subjects

• Published in: Journal of cerebral blood flow and metabolism Vol. 43; no. 1; pp. 59 - 71
• Main Authors: Picchioni, Dante, Schmidt, Kathleen C, Loutaev, Inna, Pavletic, Adriana J, Sheeler, Carrie, Bishu, Shrinivas, Balkin, Thomas J, Smith, Carolyn B
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2023
• Subjects: Brain - diagnostic imaging; Humans; Leucine; Original; Positron-Emission Tomography; Research Subjects; Sleep; sleep; protein synthesis; Leucine; N2; positron emission tomography

During sleep, reduced brain energy demands provide an opportunity for biosynthetic processes like protein synthesis. Sleep is required for some forms of memory consolidation which requires de novo protein synthesis. We measured regional cerebral protein synthesis rates (rCPS) in human subjects to as...