Elevated Expression of the cdc25A Protein Phosphatase in Colon Cancer

• Published in: Experimental cell research Vol. 240; no. 2; pp. 236 - 243
• Main Authors: Dixon, Dora, Moyana, Terence, King, Martin J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.1998
• Subjects: Animals; cdc25 Phosphatases; cdc25A; colon cancer; Colonic Neoplasms - chemically induced; Colonic Neoplasms - enzymology; Disease Models, Animal; Epithelial Cells - enzymology; mitotic index; nuclei; phosphotyrosyl protein phosphatase; Protein Tyrosine Phosphatases - metabolism; Rats; Rats, Sprague-Dawley; nuclei; cdc25A; mitotic index; phosphotyrosyl protein phosphatase; colon cancer

The nuclear protein phosphatase cdc25A has been postulated to be a protooncogene. The total nuclear phosphotyrosyl protein phosphatase (PTP) activity and the expression of cdc25A were compared in normal and cancerous colon epithelial tissue. Nuclei derived from normal mucosal epithelium and tumors w...