Dopamine D2 Receptors in Dopaminergic Neurons Modulate Performance in a Reversal Learning Task in Mice

• Published in: eNeuro Vol. 5; no. 1; p. ENEURO.0229-17.2018
• Main Authors: Linden, Jérôme, James, Alexander S., McDaniel, Colin, Jentsch, J. David
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 01.01.2018
• Subjects: Animals; Autoreceptors - physiology; Cocaine - administration & dosage; Conditioning, Operant - drug effects; Dopaminergic Neurons - physiology; Impulsive Behavior; Male; Mice, Knockout; New Research; Psychomotor Performance - drug effects; Receptors, Dopamine D2 - genetics; Receptors, Dopamine D2 - physiology; Reversal Learning - drug effects; Spatial Learning - drug effects; impulsivity; behavioral flexibility; learning; dopamine; D2

Neuroimaging studies in animal models and human subjects have each revealed that relatively low striatal dopamine D2-like receptor binding potential is associated with poor impulse control and with vulnerability for addiction-related behaviors. These studies cannot, however, disambiguate the roles f...