The cell and molecular biology of fracture healing

• Published in: Clinical orthopaedics and related research no. 355 Suppl; p. S7
• Main Author: Einhorn, T A
• Format: Journal Article
• Language: English
• Published: United States 01.10.1998
• Subjects: Animals; Apoptosis - physiology; Bone and Bones - pathology; Bone and Bones - physiopathology; Bone Remodeling - physiology; Bony Callus - pathology; Bony Callus - physiopathology; Cell Physiological Phenomena; Chondrocytes - pathology; Chondrocytes - physiology; Collagen - genetics; Disease Models, Animal; Extracellular Matrix - physiology; Extracellular Matrix Proteins - genetics; Fracture Healing - physiology; Fractures, Bone - pathology; Fractures, Bone - physiopathology; Genes, fos - genetics; Humans; Molecular Biology; Osteogenesis - physiology; Periosteum - pathology; Periosteum - physiopathology; Proliferating Cell Nuclear Antigen - genetics; Rats

Fracture healing is a complex physiologic process that involves the coordinated participation of several cell types. By using a reproducible model of experimental fracture healing in the rat, it is possible to elucidate the integrated cellular responses that signal the pathways and the role of the e...