p53 in the DNA-Damage-Repair Process

• Published in: Cold Spring Harbor perspectives in medicine Vol. 6; no. 5; p. a026070
• Main Authors: Williams, Ashley B., Schumacher, Björn
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.05.2016
• Subjects: Animals; Cell Cycle - genetics; DNA Damage; DNA Repair - genetics; Genomic Instability; Humans; Neoplasms - genetics; Transcription, Genetic; Tumor Suppressor Protein p53 - physiology

The cells in the human body are continuously challenged by a variety of genotoxic attacks. Erroneous repair of the DNA can lead to mutations and chromosomal aberrations that can alter the functions of tumor suppressor genes or oncogenes, thus causing cancer development. As a central tumor suppressor...