Regulation of Vascular Smooth Muscle Migration by Mitogen-activated Protein Kinase and Calcium/Calmodulin-dependent Protein Kinase II Signaling Pathways

• Published in: Journal of molecular and cellular cardiology Vol. 30; no. 11; pp. 2377 - 2389
• Main Authors: Lundberg, Martha S., Curto, Karen A., Bilato, Claudio, Monticone, Robert E., Crow, Michael T.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.1998
• Subjects: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology; Animals; Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors; Calcium-Calmodulin-Dependent Protein Kinases - physiology; Calcium/calmodulin-dependent protein kinase II; Cell migration; Cell Movement - drug effects; Cell Movement - physiology; Cells, Cultured; Enzyme Activation - drug effects; Enzyme Inhibitors - pharmacology; Flavonoids - pharmacology; integrins; MAPK; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - physiology; Phosphoprotein Phosphatases - antagonists & inhibitors; Phosphoprotein Phosphatases - physiology; Platelet-derived growth factor; Platelet-Derived Growth Factor - pharmacology; Rats; Rats, Wistar; Signal Transduction - drug effects; Signal Transduction - physiology; Vascular smooth muscle cells; integrins; Platelet-derived growth factor; MAPK; Calcium/calmodulin-dependent protein kinase II; Vascular smooth muscle cells; Cell migration

Platelet-derived growth factor BB (PDGF BB) activation of the mitogen-activated protein kinases (MAPK), ERK1 and ERK2, has been shown to be necessary for mitogen-stimulated proliferation, but its role in regulating cell migration and its relationship to other chemotactic signaling events, such as Ca...