Erythrocyte caspase-3 activation and oxidative imbalance in erythrocytes and in plasma of type 2 diabetic patients

• Published in: Acta diabetologica Vol. 50; no. 4; pp. 489 - 495
• Main Authors: Maellaro, Emilia, Leoncini, Silvia, Moretti, Daniele, Del Bello, Barbara, Tanganelli, Italo, De Felice, Claudio, Ciccoli, Lucia
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.08.2013; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Apoptosis; Caspase 3 - metabolism; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - enzymology; Diabetes Mellitus, Type 2 - physiopathology; Enzyme Activation; Enzymes; Erythrocytes; Erythrocytes - cytology; Erythrocytes - enzymology; Erythrocytes - metabolism; Female; Humans; Hypertension; Internal Medicine; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Original Article; Oxidative Stress; Plasma; Hypertension; Eryptosis; Oxidative stress; Diabetes; Caspase-3; Erythrocytes

An increased oxidative stress and a decreased life span of erythrocytes (RBCs) are reported in patients with diabetes. Aim of this study was to assess in RBCs from patients with type 2 diabetes whether downstream effector mechanisms of apoptosis, such as activation of caspase-3, is operative, and wh...