The Abnormal Proliferation of Hepatocytes is Associated with MC-LR and C-Terminal Truncated HBX Synergistic Disturbance of the Redox Balance

• Published in: Journal of hepatocellular carcinoma Vol. 9; pp. 1229 - 1246
• Main Authors: Cai, Dong-Mei, Mei, Fan-Biao, Zhang, Chao-Jun, An, San-Chun, Lv, Rui-Bo, Ren, Guan-Hua, Xiao, Chan-Chan, Long, Long, Huang, Tian-Ren, Deng, Wei
• Format: Journal Article
• Language: English
• Published: New Zealand Taylor & Francis Ltd 01.01.2022; Dove; Dove Medical Press
• Subjects: Amine oxidase (flavin-containing); Apoptosis; Bioengineering; Carcinogenesis; Cell cycle; Cell migration; Cell proliferation; Drinking water; Enzymes; Flow cytometry; Gene expression; Genotype & phenotype; Glutathione; Hepatitis B; Hepatitis B surface antigen; hepatitis b virus x gene; Hepatocellular carcinoma; Hepatocytes; Hepatoma; Infections; Liver cancer; Liver diseases; Microcystin-LR; microcystins-lr; Mitochondrial uncoupling protein 2; mRNA; Original Research; Oxidative stress; Pathogenesis; Reactive oxygen species; redox balance; Statistical analysis; Superoxide dismutase; Transaminase; Water quality; Western blotting; United States > US; China; Japan; redox balance; hepatitis B virus X gene; microcystins-LR; hepatocellular carcinoma

Microcystin-LR (MC-LR) and hepatitis B virus (HBV) are associated with hepatocellular carcinoma (HCC). However, the concentrations of MC-LR in drinking water and the synergistic effect of MC-LR and HBV on hepatocellular carcinogenesis through their disturbance of redox balance have not been fully el...