Reproductive hormone levels and differential mitochondria-related oxidative gene expression as potential mechanisms for gender differences in cardiosensitivity to Doxorubicin in tumor-bearing spontaneously hypertensive rats

• Published in: Cancer chemotherapy and pharmacology Vol. 76; no. 3; pp. 447 - 459
• Main Authors: Gonzalez, Yanira, Pokrzywinski, Kaytee L., Rosen, Elliot T., Mog, Steven, Aryal, Baikuntha, Chehab, Leena M., Vijay, Vikrant, Moland, Carrie L., Desai, Varsha G., Dickey, Jennifer S., Rao, V. Ashutosh
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2015; Springer Nature B.V
• Subjects: Animals; Apoptosis - physiology; Cancer Research; Doxorubicin - pharmacology; Doxorubicin - toxicity; Female; Gene Expression - drug effects; Gonadal Steroid Hormones - metabolism; Heart Diseases - chemically induced; Heart Diseases - metabolism; Hypertension - chemically induced; Hypertension - metabolism; Male; Mammary Neoplasms, Experimental - drug therapy; Mammary Neoplasms, Experimental - metabolism; Medicine; Medicine & Public Health; Mitochondria - drug effects; Mitochondria - genetics; Mitochondria - metabolism; Models, Animal; Oncology; Original Article; Oxidative Stress - genetics; Pharmacology/Toxicology; Rats; Rats, Inbred SHR; Sex Factors; Testosterone; Adriamycin; Dexrazoxane; Gender differences; Cardiotoxicity; Doxorubicin; Estradiol; Apoptosis

Purpose Chemotherapy with doxorubicin (Dox) causes dose-limiting cardiotoxicity. We investigated the role that gender has on cardiosensitivity to Dox treatment by evaluating reproductive hormone levels in male, castrated male (c-male), female and ovariectomized female (o-female) adult spontaneously...