The Pathobiology of Chronic Thromboembolic Pulmonary Hypertension

• Published in: Annals of the American Thoracic Society Vol. 13; no. Supplement_3; pp. S215 - S221
• Main Authors: Lang, Irene M., Dorfmüller, Peter, Noordegraaf, Anton Vonk
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.07.2016
• Subjects: Animals; Chronic Disease; Disease Models, Animal; Humans; Hypertension, Pulmonary - etiology; Hypertension, Pulmonary - pathology; Inflammation - pathology; Lung - pathology; Mice; Pulmonary Artery - pathology; Pulmonary Embolism - complications; Pulmonary Embolism - pathology; Pulmonary Veins - pathology; Thrombosis - complications; Ventricular Remodeling; chronic thromboembolic pulmonary hypertension; vascular biology; coagulation; review

Chronic thromboembolic pulmonary hypertension (CTEPH) is a late sequel of venous thromboembolism that cannot be completely reproduced in animal models. The prevalence of CTEPH in humans is estimated at roughly 17-20 per million; however, partly because up to 50% of patients with CTEPH never experien...