Tetracycline Antibiotics and Resistance

• Published in: Cold Spring Harbor perspectives in medicine Vol. 6; no. 4; p. a025387
• Main Author: Grossman, Trudy H.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.04.2016
• Subjects: Anti-Bacterial Agents - history; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Gram-Negative Bacteria - drug effects; Gram-Negative Bacteria - genetics; Gram-Positive Bacteria - drug effects; Gram-Positive Bacteria - genetics; History, 20th Century; Humans; Tetracycline Resistance - genetics; Tetracycline Resistance - physiology; Tetracyclines - history; Tetracyclines - pharmacology; Tetracyclines - therapeutic use

Tetracyclines possess many properties considered ideal for antibiotic drugs, including activity against Gram-positive and -negative pathogens, proven clinical safety, acceptable tolerability, and the availability of intravenous (IV) and oral formulations for most members of the class. As with all an...