New insights into the disulfide bond formation enzymes in epidithiodiketopiperazine alkaloids

• Published in: Chemical science (Cambridge) Vol. 12; no. 11; pp. 4132 - 4138
• Main Authors: Liu, Huan, Fan, Jie, Zhang, Peng, Hu, Youcai, Liu, Xingzhong, Li, Shu-Ming, Yin, Wen-Bing
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 25.03.2021; The Royal Society of Chemistry
• Subjects: Biosynthesis; Bonding; Chemical bonds; Chemistry; Enzymes; Natural products; Substrates

Epidithiodiketopiperazines (ETPs) are a group of bioactive fungal natural products and structurally feature unique transannular disulfide bridges between α, α or α, β carbons. However, no enzyme has yet been demonstrated to catalyse α, β-disulfide bond formation in these molecules. Through genome mi...