Medical devices modified at the surface by gamma-ray grafting for drug loading and delivery

• Published in: Expert opinion on drug delivery Vol. 7; no. 2; p. 173
• Main Authors: Alvarez-Lorenzo, Carmen, Bucio, Emilio, Burillo, Guillermina, Concheiro, Angel
• Format: Journal Article
• Language: English
• Published: England 01.02.2010
• Subjects: Anti-Infective Agents - administration & dosage; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacokinetics; Drug Delivery Systems - methods; Equipment and Supplies; Gamma Rays - therapeutic use; Humans; Infection Control - methods; Polymers - chemistry; Prescription Drugs - administration & dosage; Prescription Drugs - pharmacokinetics; Prostheses and Implants; Surface Properties

Medical devices with the capability of hosting drugs are being sought for prophylaxis and treatment of inflammatory response and microbial colonization and proliferation that are associated with their use. This review analyzes the interest of gamma-ray irradiation for providing medical devices with...