Let-7f Regulates the Hypoxic Response in Cerebral Ischemia by Targeting NDRG3

• Published in: Neurochemical research Vol. 42; no. 2; pp. 446 - 454
• Main Authors: Yao, Yaobing, Wang, Weiwei, Jing, Lijun, Wang, Yiwen, Li, Mingzhe, Hou, Xiaocan, Wang, Jing, Peng, Tao, Teng, Junfang, Jia, Yanjie
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2017; Springer Nature B.V
• Subjects: Animals; Animals, Newborn; Biochemistry; Biomedical and Life Sciences; Biomedicine; Brain Ischemia - genetics; Brain Ischemia - metabolism; Cell Biology; Cell Hypoxia - physiology; Gene Targeting - methods; Humans; Male; MicroRNAs - biosynthesis; MicroRNAs - genetics; Nerve Tissue Proteins - biosynthesis; Nerve Tissue Proteins - genetics; Neurochemistry; Neurology; Neurosciences; Original Paper; Rats; Rats, Sprague-Dawley; Cerebral ischemia; Let-7f; Hypoxic response; N-myc downstream-regulated gene-3 (NDRG3); microRNAs (miRNAs)
• ISSN: 0364-3190; 1573-6903; 1573-6903
• DOI: 10.1007/s11064-016-2091-x

microRNAs are a class of non-coding RNAs including approximately 22 nucleotides in length and play a pivotal role in post-transcriptional gene regulation. Currently, the role of miRNAs in the pathophysiology of ischemic stroke has been the subject of recent investigations. In particular, antagomirs...