Connective Tissue Growth Factor Activates Pluripotency Genes and Mesenchymal–Epithelial Transition in Head and Neck Cancer Cells

• Published in: Cancer research (Chicago, Ill.) Vol. 73; no. 13; pp. 4147 - 4157
• Main Authors: Chang, Cheng-Chi, Hsu, Wen-Hao, Wang, Chen-Chien, Chou, Chun-Hung, Kuo, Mark Yen-Ping, Lin, Been-Ren, Chen, Szu-Ta, Tai, Shyh-Kuan, Kuo, Min-Liang, Yang, Muh-Hwa
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.07.2013
• Subjects: Animals; Antineoplastic agents; Binding Sites; Biological and medical sciences; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Cell Movement; Connective Tissue Growth Factor - physiology; Disease-Free Survival; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - pathology; HEK293 Cells; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humans; Kaplan-Meier Estimate; Medical sciences; Mice; Mice, Nude; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Nanog Homeobox Protein; Neoplasm Invasiveness; Neoplasm Transplantation; Neoplastic Stem Cells - metabolism; Octamer Transcription Factor-3 - genetics; Octamer Transcription Factor-3 - metabolism; Oligonucleotide Array Sequence Analysis; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Pharmacology. Drug treatments; Proto-Oncogene Proteins c-jun - metabolism; SOXB1 Transcription Factors - genetics; SOXB1 Transcription Factors - metabolism; Spheroids, Cellular - metabolism; Transcriptional Activation; Transcriptome; Tumors; Gene; ENT disease; Head and neck cancer; Connective tissue growth factor; Genetics; Malignant tumor; Epithelial mesenchymal transition; Cell transformation; Cell; In vitro; Pluripotency; Cancer

The epithelial–mesenchymal transition (EMT) is a key mechanism in both embryonic development and cancer metastasis. The EMT introduces stem-like properties to cancer cells. However, during somatic cell reprogramming, mesenchymal–epithelial transition (MET), the reverse process of EMT, is a crucial s...