Globus pallidus internus deep brain stimulation as rescue therapy for refractory dyskinesias following effective subthalamic nucleus stimulation

• Published in: Stereotactic and functional neurosurgery Vol. 93; no. 1; p. 25
• Main Authors: Cook, Raymond J, Jones, Lyndsey, Fracchia, George, Anderson, Nathan, Miu, Jenny, Meagher, Linton J, Silburn, Peter A, Silberstein, Paul
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.2015
• Subjects: Adult; Aged; Antiparkinson Agents - therapeutic use; Combined Modality Therapy; Deep Brain Stimulation - instrumentation; Deep Brain Stimulation - methods; Drug Resistance; Electrodes, Implanted; Female; Globus Pallidus - physiopathology; Humans; Imaging, Three-Dimensional; Male; Parkinsonian Disorders - diagnostic imaging; Parkinsonian Disorders - drug therapy; Parkinsonian Disorders - physiopathology; Parkinsonian Disorders - therapy; Quality of Life; Recurrence; Salvage Therapy - methods; Subthalamic Nucleus - physiopathology; Tomography, X-Ray Computed

Deep brain stimulation (DBS) at the subthalamic nucleus (STN) or globus pallidus internus (GPi) can effectively treat the motor symptoms of Parkinson's disease, but dual implantation is rare. We report the first cases of additional GPi stimulation as rescue therapy for disabling dyskinesias fol...