Genetically increased circulating FUT3 level leads to reduced risk of idiopathic pulmonary fibrosis: a Mendelian randomisation study

• Published in: The European respiratory journal Vol. 59; no. 2; p. 2003979
• Main Authors: Nakanishi, Tomoko, Cerani, Agustin, Forgetta, Vincenzo, Zhou, Sirui, Allen, Richard J., Leavy, Olivia C., Koido, Masaru, Assayag, Deborah, Jenkins, R. Gisli, Wain, Louise V., Yang, Ivana V., Lathrop, G. Mark, Wolters, Paul J., Schwartz, David A., Richards, J. Brent
• Format: Journal Article
• Language: English
• Published: England European Respiratory Society 01.02.2022
• Subjects: Fucosyltransferases - genetics; Genome-Wide Association Study; Humans; Idiopathic Pulmonary Fibrosis - genetics; Mendelian Randomization Analysis - methods; Original s; Polymorphism, Single Nucleotide

Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal fibrotic interstitial lung disease. Few circulating biomarkers have been identified to have causal effects on IPF. To identify candidate IPF-influencing circulating proteins, we undertook an efficient screen of circulating proteins by apply...