In Vivo Cancer Dual-Targeting and Dual-Modality Imaging with Functionalized Quantum Dots

• Published in: Journal of Nuclear Medicine Vol. 56; no. 8; pp. 1278 - 1284
• Main Authors: Hu, Kongzhen, Wang, Hongliang, Tang, Ganghua, Huang, Tingting, Tang, Xiaolan, Liang, Xiang, Yao, Shaobo, Nie, Dahong
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.08.2015
• Subjects: Animals; Biocompatible Materials - chemistry; Bombesin - pharmacokinetics; Cancer; Cells; Copper Radioisotopes; Cytotoxicity; Female; Fluorescence; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms - diagnostic imaging; Nitrophenols - chemistry; Oligopeptides - chemistry; Peptides - chemistry; Positron-Emission Tomography; Prostatic Neoplasms - diagnostic imaging; Quantum Dots; Receptors, Bombesin - metabolism; Rodents; Semiconductors; Spectrometry, Fluorescence; Tissue Distribution; Tumors; quantum dots; integrin αvβ3; GRPR; fluorescence; PET

Semiconductor quantum dots (QDs), after surface modification to provide water solubility and biocompatibility, have a promising future in biomedical applications. In this study, a dual receptor-targeting dual-modality PET/near-infrared fluorescence (NIRF) probe was developed for accurate assessment...