The energy landscape of a protein switch

• Published in: Physical chemistry chemical physics : PCCP Vol. 16; no. 14; pp. 647 - 6421
• Main Authors: Chen, Szu-Hua, Elber, Ron
• Format: Journal Article
• Language: English
• Published: England 14.04.2014
• Subjects: Amino Acid Sequence; Correlation; Enrichment; Mathematical analysis; Mathematical models; Melting; Molecular Dynamics Simulation; Molecular structure; Protein Structure, Tertiary; Proteins; Proteins - chemistry; Proteins - metabolism; Switches; Thermodynamics; Transition Temperature

Protein switches are made of highly similar sequences that fold to dramatically different structures. A structural switching system with 31 sequence variants for α and α+β folds has been illustrated experimentally by He et al. , Structure , 2012, 20 , 283 and is investigated computationally in the p...