NMDA Antagonists for Refractory Seizures

• Published in: Neurocritical care Vol. 20; no. 3; pp. 502 - 513
• Main Authors: Zeiler, F. A., Teitelbaum, J., Gillman, L. M., West, M.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.06.2014; Springer Nature B.V
• Subjects: Cohort analysis; Convulsions & seizures; Critical care; Critical Care Medicine; Drug Resistance; Excitatory Amino Acid Antagonists - therapeutic use; Human subjects; Humans; Intensive; Internal Medicine; Ketamine; Ketamine - therapeutic use; Medicine; Medicine & Public Health; Neurology; Patients; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Review Article; Status Epilepticus - drug therapy; Systematic review; NMDA antagonists; Ketamine; Refractory status; Status epilepticus

Refractory status epilepticus (RSE) poses significant challenge, with a variety of novel therapeutics employed. Our goal was to evaluate the effectiveness of N -methyl d -aspartate (NMDA) receptor antagonists in the control of RSE. We performed a systematic review of all the literature, with all art...