Identification of Human Semaphorin E Gene Expression in Rheumatoid Synovial Cells by mRNA Differential Display

• Published in: Biochemical and biophysical research communications Vol. 234; no. 1; pp. 153 - 156
• Main Authors: Mangasser-Stephan, Kerstin, Dooley, Steven, Welter, Cornelius, Mutschler, Wolf, Hanselmann, Rainer G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.05.1997
• Subjects: Arthritis, Rheumatoid - etiology; Arthritis, Rheumatoid - genetics; Blotting, Northern; Cells, Cultured; Cloning, Molecular; DNA, Complementary - chemistry; Electrophoresis, Agar Gel; Gene Expression Regulation; Humans; Membrane Proteins - genetics; Molecular Sequence Data; Nerve Tissue Proteins - genetics; RNA, Messenger - genetics; Sequence Analysis; Synovial Membrane - metabolism; Up-Regulation

Rheumatoid arthritis (RA) is characterised by chronic inflammation of synovial tissue with aggressive proliferation of synovial cells causing destruction of cartilage and bone. Immunopathological mechanisms, infectious causes and genetic factors have been discussed, but the etiology of the disease h...