Microbial production of (S)-1-phenyl-1,3-propanediol by stereospecific reduction of 3-hydroxy-1-phenylpropane-1-one

• Published in: Journal of molecular catalysis. B, Enzymatic Vol. 56; no. 4; pp. 283 - 287
• Main Authors: Kira, Ikuo, Suzuki, Takayuki, Onishi, Norimasa, Watanabe, Kazuhiro, Nakanishi, Eizi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.04.2009; Elsevier
• Subjects: (S)-1-Phenyl-1,3-propanediol; 3-Hydroxy-1-phenylpropane-1-one; Bioconversions. Hemisynthesis; Biological and medical sciences; Biotechnology; Fundamental and applied biological sciences. Psychology; Methods. Procedures. Technologies; Optical purity; Stereospecific reduction; Williopsis saturnus var. mrakii; Stereospecific reduction; (S)-1-Phenyl-1,3-propanediol; Optical purity; Williopsis saturnus var. mrakii; 3-Hydroxy-1-phenylpropane-1-one; Reduction; Production; Stereospecificity; Microorganism; Propanediol

A novel microbial method of synthesizing (S)-1-phenyl-1,3-propanediol [(S)-PPD] was developed in this study. Our laboratory stock cultures were screened for microorganisms that stereospecifically produced (S)-PPD from 3-hydroxy-1-phenylpropane-1-one (HPPO) using an intact cell system. Of the 828 str...