Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein

• Published in: Journal of Nuclear Medicine Vol. 56; no. 5; pp. 701 - 706
• Main Authors: Lyoo, Chul Hyoung, Ikawa, Masamichi, Liow, Jeih-San, Zoghbi, Sami S., Morse, Cheryl L., Pike, Victor W., Fujita, Masahiro, Innis, Robert B., Kreisl, William Charles
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.05.2015
• Subjects: Aged; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Alzheimer's disease; Binding sites; Cerebellum - diagnostic imaging; Cerebellum - metabolism; Female; Humans; Inflammation - diagnostic imaging; Inflammation - metabolism; Intubation; Ligands; Male; Medical imaging; Middle Aged; Nuclear medicine; Positron-Emission Tomography; Protein Binding; Pyrimidines - metabolism; Receptors, GABA - metabolism; Reference Standards; 11C-PBR28; positron emission tomography; Alzheimer disease; neuroinflammation; ratio method

Alzheimer disease (AD) is associated with an increase in the brain of the 18-kDa translocator protein (TSPO), which is overexpressed in activated microglia and reactive astrocytes. Measuring the density of TSPO with PET typically requires absolute quantitation with arterial blood sampling, because a...