Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons - Vevea, Jason D; Kusick, Grant F; Courtney, Kevin C; Chen, Erin; Watanabe, Shigeki; Chapman, Edwin R (eLife, 2021)
Keywords: Alzheimer's disease; Amyloid Precursor Protein Secretases - metabolism; Animals; Axon guidance; Axons - enzymology; Axons - ultrastructure; Cell Membrane - enzymology; Cell Membrane - ultrastructure; Cells, Cultured; Electron microscopy; Exocytosis; Experiments; gamma secretase; Hippocampus; Hippocampus - enzymology; Hippocampus - ultrastructure; iGluSnFR; Lipoylation; Localization; Membrane proteins; Membranes; Mice; Mice, Knockout; Molecular Docking Simulation; Neuronal Plasticity; Neuroscience; Paired-pulse facilitation; Palmitoylation; Protein Processing, Post-Translational; Protein Transport; Proteolysis; Rats; Rats, Sprague-Dawley; Secretase; short-term synaptic plasticity; Synaptic plasticity; Synaptic Transmission; Synaptic vesicles; Synaptic Vesicles - enzymology; Synaptic Vesicles - ultrastructure; Synaptotagmin; Synaptotagmin 7; Synaptotagmins - genetics; Synaptotagmins - metabolism; Time Factors; zap-and-freeze; zap-and-freeze; mouse; hippocampus; rat; gamma secretase; neuroscience; iGluSnFR; short-term synaptic plasticity; Synaptotagmin 7