Polymorphisms within ASTN2 gene are associated with age at onset of Alzheimer’s disease
Alzheimer’s disease (AD) is a multifactorial neurological condition associated with genetic profiles that are still not completely understood. We performed a family-based low-density genome-wide association analysis of age at onset (AAO) in AD (244 patients and their relatives) using Illumina 6 K si...
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Published in | Journal of Neural Transmission Vol. 122; no. 5; pp. 701 - 708 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Springer Vienna
01.05.2015
Springer Nature B.V |
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Abstract | Alzheimer’s disease (AD) is a multifactorial neurological condition associated with genetic profiles that are still not completely understood. We performed a family-based low-density genome-wide association analysis of age at onset (AAO) in AD (244 patients and their relatives) using Illumina 6 K single-nucleotide polymorphisms (SNPs) panel and the FBAT-logrank statistic. We observed 10 SNPs associated with AAO in AD with
p
< 2 × 10
−3
. The most significant hit within a known gene, the neuronal protein astrotactin 2 (
ASTN2)
, was SNP rs1334071 (
p
= 8.74 × 10
−4
).
ASTN2
has been implicated in several neuropsychiatric disorders, including cognitive disorders, autism and schizophrenia. We then conducted a replication study focusing on
ASTN2
gene in a Canadian sample of 791 AD patients and 782 controls using the logrank test. Five
ASTN2
SNPs (highest association is rs16933774 with
p
= 0.0053) showed associations with AAO in this Canadian sample (
p
< 0.05). Furthermore, Kaplan–Meier survival analysis of SNP rs16933774 showed that the AAO of AD in individuals heterozygous for AG genotype of rs16933774 (median of AAO = 68.5 years) was approximately 4.5 years earlier than those individuals having the AA genotype (median of AAO = 73 years). In conclusion, a significant association of
ASTN2
genetic variants with AAO of AD in two independent samples demonstrates a role for
ASTN2
in the pathogenesis of AD. Future functional studies of this gene may help to characterize the genetic architecture of the AAO of AD. Genetic factors in AAO may be a critical factor for early AD intervention and prevention efforts. |
---|---|
AbstractList | Alzheimer's disease (AD) is a multifactorial neurological condition associated with genetic profiles that are still not completely understood. We performed a family-based low-density genome-wide association analysis of age at onset (AAO) in AD (244 patients and their relatives) using Illumina 6 K single-nucleotide polymorphisms (SNPs) panel and the FBAT-logrank statistic. We observed 10 SNPs associated with AAO in AD with p < 2 × 10(-3). The most significant hit within a known gene, the neuronal protein astrotactin 2 (ASTN2), was SNP rs1334071 (p = 8.74 × 10(-4)). ASTN2 has been implicated in several neuropsychiatric disorders, including cognitive disorders, autism and schizophrenia. We then conducted a replication study focusing on ASTN2 gene in a Canadian sample of 791 AD patients and 782 controls using the logrank test. Five ASTN2 SNPs (highest association is rs16933774 with p = 0.0053) showed associations with AAO in this Canadian sample (p < 0.05). Furthermore, Kaplan-Meier survival analysis of SNP rs16933774 showed that the AAO of AD in individuals heterozygous for AG genotype of rs16933774 (median of AAO = 68.5 years) was approximately 4.5 years earlier than those individuals having the AA genotype (median of AAO = 73 years). In conclusion, a significant association of ASTN2 genetic variants with AAO of AD in two independent samples demonstrates a role for ASTN2 in the pathogenesis of AD. Future functional studies of this gene may help to characterize the genetic architecture of the AAO of AD. Genetic factors in AAO may be a critical factor for early AD intervention and prevention efforts. Alzheimer's disease (AD) is a multifactorial neurological condition associated with genetic profiles that are still not completely understood. We performed a family-based low-density genome-wide association analysis of age at onset (AAO) in AD (244 patients and their relatives) using Illumina 6 K single-nucleotide polymorphisms (SNPs) panel and the FBAT-logrank statistic. We observed 10 SNPs associated with AAO in AD with p < 2 × 10(-3). The most significant hit within a known gene, the neuronal protein astrotactin 2 (ASTN2), was SNP rs1334071 (p = 8.74 × 10(-4)). ASTN2 has been implicated in several neuropsychiatric disorders, including cognitive disorders, autism and schizophrenia. We then conducted a replication study focusing on ASTN2 gene in a Canadian sample of 791 AD patients and 782 controls using the logrank test. Five ASTN2 SNPs (highest association is rs16933774 with p = 0.0053) showed associations with AAO in this Canadian sample (p < 0.05). Furthermore, Kaplan-Meier survival analysis of SNP rs16933774 showed that the AAO of AD in individuals heterozygous for AG genotype of rs16933774 (median of AAO = 68.5 years) was approximately 4.5 years earlier than those individuals having the AA genotype (median of AAO = 73 years). In conclusion, a significant association of ASTN2 genetic variants with AAO of AD in two independent samples demonstrates a role for ASTN2 in the pathogenesis of AD. Future functional studies of this gene may help to characterize the genetic architecture of the AAO of AD. Genetic factors in AAO may be a critical factor for early AD intervention and prevention efforts. Alzheimer’s disease (AD) is a multifactorial neurological condition associated with genetic profiles that are still not completely understood. We performed a family-based low-density genome-wide association analysis of age at onset (AAO) in AD (244 patients and their relatives) using Illumina 6 K single-nucleotide polymorphisms (SNPs) panel and the FBAT-logrank statistic. We observed 10 SNPs associated with AAO in AD with p < 2 × 10 −3 . The most significant hit within a known gene, the neuronal protein astrotactin 2 ( ASTN2) , was SNP rs1334071 ( p = 8.74 × 10 −4 ). ASTN2 has been implicated in several neuropsychiatric disorders, including cognitive disorders, autism and schizophrenia. We then conducted a replication study focusing on ASTN2 gene in a Canadian sample of 791 AD patients and 782 controls using the logrank test. Five ASTN2 SNPs (highest association is rs16933774 with p = 0.0053) showed associations with AAO in this Canadian sample ( p < 0.05). Furthermore, Kaplan–Meier survival analysis of SNP rs16933774 showed that the AAO of AD in individuals heterozygous for AG genotype of rs16933774 (median of AAO = 68.5 years) was approximately 4.5 years earlier than those individuals having the AA genotype (median of AAO = 73 years). In conclusion, a significant association of ASTN2 genetic variants with AAO of AD in two independent samples demonstrates a role for ASTN2 in the pathogenesis of AD. Future functional studies of this gene may help to characterize the genetic architecture of the AAO of AD. Genetic factors in AAO may be a critical factor for early AD intervention and prevention efforts. Alzheimer's disease (AD) is a multifactorial neurological condition associated with genetic profiles that are still not completely understood. We performed a family-based low-density genome-wide association analysis of age at onset (AAO) in AD (244 patients and their relatives) using Illumina 6 K single-nucleotide polymorphisms (SNPs) panel and the FBAT-logrank statistic. We observed 10 SNPs associated with AAO in AD with p < 2 × 10^sup -3^. The most significant hit within a known gene, the neuronal protein astrotactin 2 (ASTN2), was SNP rs1334071 (p = 8.74 × 10^sup -4^). ASTN2 has been implicated in several neuropsychiatric disorders, including cognitive disorders, autism and schizophrenia. We then conducted a replication study focusing on ASTN2 gene in a Canadian sample of 791 AD patients and 782 controls using the logrank test. Five ASTN2 SNPs (highest association is rs16933774 with p = 0.0053) showed associations with AAO in this Canadian sample (p < 0.05). Furthermore, Kaplan-Meier survival analysis of SNP rs16933774 showed that the AAO of AD in individuals heterozygous for AG genotype of rs16933774 (median of AAO = 68.5 years) was approximately 4.5 years earlier than those individuals having the AA genotype (median of AAO = 73 years). In conclusion, a significant association of ASTN2 genetic variants with AAO of AD in two independent samples demonstrates a role for ASTN2 in the pathogenesis of AD. Future functional studies of this gene may help to characterize the genetic architecture of the AAO of AD. Genetic factors in AAO may be a critical factor for early AD intervention and prevention efforts. Alzheimer's disease (AD) is a multifactorial neurological condition associated with genetic profiles that are still not completely understood. We performed a family-based low-density genome-wide association analysis of age at onset (AAO) in AD (244 patients and their relatives) using Illumina 6 K single-nucleotide polymorphisms (SNPs) panel and the FBAT-logrank statistic. We observed 10 SNPs associated with AAO in AD with p < 2 x 10 super(-3). The most significant hit within a known gene, the neuronal protein astrotactin 2 (ASTN2), was SNP rs1334071 (p = 8.74 x 10 super(-4)). ASTN2 has been implicated in several neuropsychiatric disorders, including cognitive disorders, autism and schizophrenia. We then conducted a replication study focusing on ASTN2 gene in a Canadian sample of 791 AD patients and 782 controls using the logrank test. Five ASTN2 SNPs (highest association is rs16933774 with p = 0.0053) showed associations with AAO in this Canadian sample (p < 0.05). Furthermore, Kaplan-Meier survival analysis of SNP rs16933774 showed that the AAO of AD in individuals heterozygous for AG genotype of rs16933774 (median of AAO = 68.5 years) was approximately 4.5 years earlier than those individuals having the AA genotype (median of AAO = 73 years). In conclusion, a significant association of ASTN2 genetic variants with AAO of AD in two independent samples demonstrates a role for ASTN2 in the pathogenesis of AD. Future functional studies of this gene may help to characterize the genetic architecture of the AAO of AD. Genetic factors in AAO may be a critical factor for early AD intervention and prevention efforts. |
Author | Mao, ChunXiang Briones, David Xu, Chun Wang, Ke-Sheng Rubin, Lewis Luo, Xingguang Zuo, Lingjun Tonarelli, Silvina Su, Brenda Wang, Liang |
Author_xml | – sequence: 1 givenname: Ke-Sheng surname: Wang fullname: Wang, Ke-Sheng organization: Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University – sequence: 2 givenname: Silvina surname: Tonarelli fullname: Tonarelli, Silvina organization: Departments of Psychiatry, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center – sequence: 3 givenname: Xingguang surname: Luo fullname: Luo, Xingguang organization: Department of Psychiatry, Yale University School of Medicine – sequence: 4 givenname: Liang surname: Wang fullname: Wang, Liang organization: Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University – sequence: 5 givenname: Brenda surname: Su fullname: Su, Brenda organization: Colleges of Bioinformatics Science and Technology, Harbin Medical University – sequence: 6 givenname: Lingjun surname: Zuo fullname: Zuo, Lingjun organization: Department of Psychiatry, Yale University School of Medicine – sequence: 7 givenname: ChunXiang surname: Mao fullname: Mao, ChunXiang organization: Department of Pediatrics, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center – sequence: 8 givenname: Lewis surname: Rubin fullname: Rubin, Lewis organization: Department of Pediatrics, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center – sequence: 9 givenname: David surname: Briones fullname: Briones, David organization: Departments of Psychiatry, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center – sequence: 10 givenname: Chun surname: Xu fullname: Xu, Chun email: chun.xu@ttuhsc.edu organization: Department of Pediatrics, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center |
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Cites_doi | 10.1017/S0317167100013949 10.1097/GIM.0b013e31816b64dc 10.1016/j.neuroimage.2008.10.003 10.1073/pnas.1000274107 10.1086/519795 10.1093/bioinformatics/btl507 10.1097/NRL.0b013e318187e76b 10.1016/j.jalz.2010.01.011 10.1002/humu.22442 10.1016/j.ajhg.2008.09.011 10.1016/j.braindev.2013.04.013 10.1001/archneurol.2007.3 10.1086/339815 10.1002/ajmg.1608 10.1038/ng.2307 10.1093/bioinformatics/bth457 10.1016/j.schres.2010.09.002 10.1038/ng.2237 10.1002/ana.410300310 10.1523/JNEUROSCI.0032-10.2010 10.1007/s00702-008-0119-3 10.1001/archneur.63.9.1307 10.1086/302553 10.1038/nrg2989 10.1038/mp.2010.14 10.1007/s11019-006-9005-7 10.1016/j.gene.2004.10.004 10.1007/s00702-013-1091-0 10.1086/302710 10.1001/archneur.65.11.1518 10.1038/ng1337 10.1126/scitranslmed.3002464 10.1093/hmg/ddt669 |
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Keywords | Logrank test Single-nucleotide polymorphisms Alzheimer’s disease Genome-wide association Age of onset |
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References | Barrett, Fry, Maller, Daly (CR2) 2005; 21 Brickell, Steinbart, Rumbaugh, Payami, Schellenberg, Van Deerlin, Yuan, Bird (CR5) 2006; 63 Lutz, Crenshaw, Saunders, Roses (CR20) 2010; 6 Ott, Kamatani, Lathrop (CR22) 2011; 12 CR18 Dekkers, Rikkert (CR8) 2006; 9 Hoffmann, Lange (CR12) 2006; 22 CR17 Wang, Wang, Aragon, Ciubuc, Arana, Mao, Petty, Briones, Su, Luo, Camarillo, Escamilla, Xu (CR30) 2014; 121 Campion, Dumanchin, Hannequin, Dubois, Belliard, Puel, Thomas-Anterion, Michon, Martin, Charbonnier, Raux, Camuzat, Penet, Mesnage, Martinez, Clerget-Darpoux, Brice, Frebourg (CR6) 1999; 65 Li, Wetten, Li, St Jean, Upmanyu, Surh, Hosford, Barnes, Briley, Borrie, Coletta, Delisle, Dhalla, Ehm, Feldman, Fornazzari, Gauthier, Goodgame, Guzman, Hammond, Hollingworth, Hsiung, Johnson, Kelly, Keren, Kertesz, King, Lovestone, Loy-English, Matthews, Owen, Plumpton, Pryse-Phillips, Prinjha, Richardson, Saunders, Slater, St George-Hyslop, Stinnett, Swartz, Taylor, Wherrett, Williams, Yarnall, Gibson, Irizarry, Middleton, Roses (CR16) 2008; 65 Vrijenhoek, Buizer-Voskamp, van der Stelt, Strengman, Sabatti, Geurts van Kessel, Brunner, Ophoff, Veltman (CR27) 2008; 83 Filippini, Rao, Wetten, Gibson, Borrie, Guzman, Kertesz, Loy-English, Williams, Nichols, Whitcher, Matthews (CR9) 2009; 44 Spielman, McGinnis, Ewens (CR26) 1993; 52 Lee, Cheng, Graff-Radford, Foroud, Mayeux (CR13) 2008; 65 Li, Scott, Hedges, Zhang, Gaskell, Nance, Watts, Hubble, Koller, Pahwa, Stern, Hiner, Jankovic, Allen, Goetz, Mastaglia, Stajich, Gibson, Middleton, Saunders, Scott, Small, Nicodemus, Reed, Schmechel, Welsh-Bohmer, Conneally, Roses, Gilbert, Vance, Haines, Pericak-Vance (CR15) 2002; 70 Adkins, Aberg, McClay, Bukszár, Zhao, Jia, Stroup, Perkins, McEvoy, Lieberman, Sullivan, van den Oord (CR1) 2011; 16 Daw, Payami, Nemens, Nochlin, Bird, Schellenberg, Wijsman (CR7) 2000; 66 Lesch, Timmesfeld, Renner, Halperin, Röser, Nguyen, Craig, Romanos, Heine, Meyer, Freitag, Warnke, Romanos, Schäfer, Walitza, Reif, Stephan, Jacob (CR14) 2008; 115 Glessner, Reilly, Kim, Takahashi, Albano, Hou, Bradfield, Zhang, Sleiman, Flory, Imielinski, Frackelton, Chiavacci, Thomas, Garris, Otieno, Davidson, Weiser, Reichenberg, Davis, Friedman, Cappola, Margulies, Rader, Grant, Buxbaum, Gur, Hakonarson (CR11) 2010; 107 Pedersen, Posner, Gatz (CR23) 2001; 105 Purcell, Neale, Todd-Brown, Thomas, Ferreira, Bender, Maller, Sklar, de Bakker, Daly, Sham (CR24) 2007; 81 Wang, Liu, Aragam (CR29) 2010; 124 Rocca, Hofman, Brayne, Breteler, Clarke, Copeland, Dartigues, Engedal, Hagnell, Heeren (CR25) 1991; 30 Freilinger, Anttila, de Vries, Malik, Kallela, Terwindt, Pozo-Rosich, Winsvold, Nyholt, van Oosterhout, Artto, Todt, Hämäläinen, Fernández-Morales, Louter, Kaunisto, Schoenen, Raitakari, Lehtimäki, Vila-Pueyo, Göbel, Wichmann, Sintas, Uitterlinden, Hofman, Rivadeneira, Heinze, Tronvik, van Duijn, Kaprio, Cormand, Wessman, Frants, Meitinger, Müller-Myhsok, Zwart, Färkkilä, Macaya, Ferrari, Kubisch, Palotie, Dichgans, van den Maagdenberg (CR34) 2012; 44 Bird (CR3) 2008; 10 Wu, Rosa-Neto, Hsiung, Sadovnick, Masellis, Black, Jia, Gauthier (CR33) 2012; 39 Bis, DeCarli, Smith, van der Lijn, Crivello, Fornage, Debette, Shulman, Schmidt, Srikanth, Schuur, Yu, Choi, Sigurdsson, Verhaaren, DeStefano, Lambert, Jack, Struchalin, Stankovich, Ibrahim-Verbaas, Fleischman, Zijdenbos, den Heijer, Mazoyer, Coker, Enzinger, Danoy, Amin, Arfanakis, van Buchem, de Bruijn, Beiser, Dufouil, Huang, Cavalieri, Thomson, Niessen, Chibnik, Gislason, Hofman, Pikula, Amouyel, Freeman, Phan, Oostra, Stein, Medland, Vasquez, Hibar, Wright, Franke, Martin, Thompson, Nalls, Uitterlinden, Au, Elbaz, Beare, van Swieten, Lopez, Harris, Chouraki, Breteler, De Jager, Becker, Vernooij, Knopman, Fazekas, Wolf, van der Lugt, Gudnason, Longstreth, Brown, Bennett, van Duijn, Mosley, Schmidt, Tzourio, Launer, Ikram, Seshadri (CR4) 2012; 44 Garcia, Castillo (CR10) 2005; 344 Vulto-van Silfhout, Hehir-Kwa, van Bon, Schuurs-Hoeijmakers, Meader, Hellebrekers, Thoonen, de Brouwer, Brunner, Webber, Pfundt, de Leeuw, de Vries (CR28) 2013; 34 Williamson, Goldman, Marder (CR31) 2009; 15 Lo-Castro, Curatolo (CR19) 2014; 36 Marchini, Cardon, Phillips, Donnelly (CR21) 2004; 36 Wilson, Fryer, Fang, Hatten (CR32) 2010; 30 1952826 - Ann Neurol. 1991 Sep;30(3):381-90 24381304 - Hum Mol Genet. 2014 May 15;23 (10 ):2752-68 15052271 - Nat Genet. 2004 May;36(5):512-7 20195266 - Mol Psychiatry. 2011 Mar;16(3):321-32 23726375 - Brain Dev. 2014 Mar;36(3):185-93 17701901 - Am J Hum Genet. 2007 Sep;81(3):559-75 18839057 - J Neural Transm (Vienna). 2008 Nov;115(11):1573-85 19276785 - Neurologist. 2009 Mar;15(2):80-6 20889312 - Schizophr Res. 2010 Dec;124(1-3):192-9 8447318 - Am J Hum Genet. 1993 Mar;52(3):506-16 24061483 - J Neural Transm (Vienna). 2014 Feb;121(2):183-92 22728850 - Can J Neurol Sci. 2012 Jul;39(4):436-45 20489179 - Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10584-9 11875758 - Am J Hum Genet. 2002 Apr;70(4):985-93 16966510 - Arch Neurol. 2006 Sep;63(9):1307-11 21629274 - Nat Rev Genet. 2011 Jun 01;12(7):465-74 17998437 - Arch Neurol. 2008 Jan;65(1):45-53 10631151 - Am J Hum Genet. 2000 Jan;66(1):196-204 21832240 - Sci Transl Med. 2011 Aug 10;3(95):95ra75 22504421 - Nat Genet. 2012 Apr 15;44(5):545-51 24038936 - Hum Mutat. 2013 Dec;34(12):1679-87 20298972 - Alzheimers Dement. 2010 Mar;6(2):125-31 20573900 - J Neurosci. 2010 Jun 23;30(25):8529-40 22683712 - Nat Genet. 2012 Jun 10;44(7):777-82 15656990 - Gene. 2005 Jan 3;344:241-50 18414205 - Genet Med. 2008 Apr;10(4):231-9 10441572 - Am J Hum Genet. 1999 Sep;65(3):664-70 16847726 - Med Health Care Philos. 2006;9(3):273-84 15297300 - Bioinformatics. 2005 Jan 15;21(2):263-5 17021156 - Bioinformatics. 2006 Dec 15;22(24):3103-5 18940311 - Am J Hum Genet. 2008 Oct;83(4):504-10 19001172 - Arch Neurol. 2008 Nov;65(11):1518-26 11803520 - Am J Med Genet. 2001 Dec 8;105(8):724-8 19013250 - Neuroimage. 2009 Feb 1;44(3):724-8 KL Brickell (1306_CR5) 2006; 63 RS Spielman (1306_CR26) 1993; 52 H Li (1306_CR16) 2008; 65 L Wu (1306_CR33) 2012; 39 D Campion (1306_CR6) 1999; 65 DE Adkins (1306_CR1) 2011; 16 PM Wilson (1306_CR32) 2010; 30 J Williamson (1306_CR31) 2009; 15 KS Wang (1306_CR29) 2010; 124 J Garcia (1306_CR10) 2005; 344 TD Bird (1306_CR3) 2008; 10 J Marchini (1306_CR21) 2004; 36 EW Daw (1306_CR7) 2000; 66 T Hoffmann (1306_CR12) 2006; 22 JC Barrett (1306_CR2) 2005; 21 JT Glessner (1306_CR11) 2010; 107 AT Vulto-van Silfhout (1306_CR28) 2013; 34 N Filippini (1306_CR9) 2009; 44 WA Rocca (1306_CR25) 1991; 30 T Vrijenhoek (1306_CR27) 2008; 83 KSXN Wang (1306_CR30) 2014; 121 YJ Li (1306_CR15) 2002; 70 W Dekkers (1306_CR8) 2006; 9 J Ott (1306_CR22) 2011; 12 1306_CR17 1306_CR18 NL Pedersen (1306_CR23) 2001; 105 KP Lesch (1306_CR14) 2008; 115 JH Lee (1306_CR13) 2008; 65 JC Bis (1306_CR4) 2012; 44 S Purcell (1306_CR24) 2007; 81 T Freilinger (1306_CR34) 2012; 44 A Lo-Castro (1306_CR19) 2014; 36 MW Lutz (1306_CR20) 2010; 6 |
References_xml | – volume: 39 start-page: 436 year: 2012 end-page: 445 ident: CR33 article-title: Early-onset familial Alzheimer’s disease (EOFAD) publication-title: Can J Neurol Sci doi: 10.1017/S0317167100013949 contributor: fullname: Gauthier – ident: CR18 – volume: 10 start-page: 231 year: 2008 end-page: 239 ident: CR3 article-title: Genetic aspects of Alzheimer disease publication-title: Genet Med doi: 10.1097/GIM.0b013e31816b64dc contributor: fullname: Bird – volume: 44 start-page: 724 year: 2009 end-page: 728 ident: CR9 article-title: Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer’s disease publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.10.003 contributor: fullname: Matthews – volume: 107 start-page: 10584 year: 2010 end-page: 10589 ident: CR11 article-title: Strong synaptic transmission impact by copy number variations in schizophrenia publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1000274107 contributor: fullname: Hakonarson – volume: 81 start-page: 559 year: 2007 end-page: 575 ident: CR24 article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses publication-title: Am J Hum Genet doi: 10.1086/519795 contributor: fullname: Sham – volume: 22 start-page: 3103 year: 2006 end-page: 3105 ident: CR12 article-title: P2BAT: a massive parallel implementation of PBAT for genome-wide association studies in R publication-title: Bioinformatics doi: 10.1093/bioinformatics/btl507 contributor: fullname: Lange – volume: 15 start-page: 80 year: 2009 end-page: 86 ident: CR31 article-title: Genetic aspects of Alzheimer disease publication-title: Neurologist doi: 10.1097/NRL.0b013e318187e76b contributor: fullname: Marder – volume: 6 start-page: 125 year: 2010 end-page: 131 ident: CR20 article-title: Genetic variation at a single locus and age of onset for Alzheimer’s disease publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2010.01.011 contributor: fullname: Roses – volume: 34 start-page: 1679 year: 2013 end-page: 1687 ident: CR28 article-title: Clinical significance of de novo and inherited copy-number variation publication-title: Hum Mutat doi: 10.1002/humu.22442 contributor: fullname: de Vries – volume: 52 start-page: 506 year: 1993 end-page: 516 ident: CR26 article-title: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM) publication-title: Am J Hum Genet contributor: fullname: Ewens – volume: 83 start-page: 504 year: 2008 end-page: 510 ident: CR27 article-title: Recurrent CNVs disrupt three candidate genes in schizophrenia patients publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2008.09.011 contributor: fullname: Veltman – volume: 36 start-page: 185 year: 2014 end-page: 193 ident: CR19 article-title: Epilepsy associated with autism and attention deficit hyperactivity disorder: is there a genetic link? publication-title: Brain Dev doi: 10.1016/j.braindev.2013.04.013 contributor: fullname: Curatolo – volume: 65 start-page: 45 year: 2008 end-page: 53 ident: CR16 article-title: Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease publication-title: Arch Neurol doi: 10.1001/archneurol.2007.3 contributor: fullname: Roses – volume: 70 start-page: 985 year: 2002 end-page: 993 ident: CR15 article-title: Age at onset in two common neurodegenerative diseases is genetically controlled publication-title: Am J Hum Genet doi: 10.1086/339815 contributor: fullname: Pericak-Vance – volume: 105 start-page: 724 year: 2001 end-page: 728 ident: CR23 article-title: Multiple-threshold models for genetic influences on age of onset for Alzheimer disease: findings in Swedish twins publication-title: Am J Med Genet doi: 10.1002/ajmg.1608 contributor: fullname: Gatz – volume: 44 start-page: 777 year: 2012 end-page: 782 ident: CR34 article-title: Genome-wide association analysis identifies susceptibility loci for migraine without aura publication-title: Nat Genet doi: 10.1038/ng.2307 contributor: fullname: van den Maagdenberg – volume: 21 start-page: 263 year: 2005 end-page: 265 ident: CR2 article-title: Haploview: analysis and visualization of LD and haplotype maps publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth457 contributor: fullname: Daly – volume: 124 start-page: 192 year: 2010 end-page: 199 ident: CR29 article-title: A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder publication-title: Schizophr Res doi: 10.1016/j.schres.2010.09.002 contributor: fullname: Aragam – volume: 44 start-page: 545 year: 2012 end-page: 551 ident: CR4 article-title: Common variants at 12q14 and 12q24 are associated with hippocampal volume publication-title: Nat Genet doi: 10.1038/ng.2237 contributor: fullname: Seshadri – volume: 30 start-page: 381 year: 1991 end-page: 390 ident: CR25 article-title: Frequency and distribution of Alzheimer’s disease in Europe: a collaborative study of 1980-1990 prevalence findings. The EURODEM-Prevalence Research Group publication-title: Ann Neurol doi: 10.1002/ana.410300310 contributor: fullname: Heeren – volume: 30 start-page: 8529 year: 2010 end-page: 8540 ident: CR32 article-title: Astn2, a novel member of the astrotactin gene family, regulates the trafficking of ASTN1 during glial-guided neuronal migration publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0032-10.2010 contributor: fullname: Hatten – ident: CR17 – volume: 115 start-page: 1573 year: 2008 end-page: 1585 ident: CR14 article-title: Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies publication-title: J Neural Transm doi: 10.1007/s00702-008-0119-3 contributor: fullname: Jacob – volume: 63 start-page: 1307 year: 2006 end-page: 1311 ident: CR5 article-title: Early-onset Alzheimer disease in families with late-onset Alzheimer disease: a potential important subtype of familial Alzheimer disease publication-title: Arch Neurol doi: 10.1001/archneur.63.9.1307 contributor: fullname: Bird – volume: 65 start-page: 664 year: 1999 end-page: 670 ident: CR6 article-title: Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum publication-title: Am J Hum Genet doi: 10.1086/302553 contributor: fullname: Frebourg – volume: 12 start-page: 465 year: 2011 end-page: 474 ident: CR22 article-title: Family-based designs for genome-wide association studies publication-title: Nat Rev Genet doi: 10.1038/nrg2989 contributor: fullname: Lathrop – volume: 16 start-page: 321 year: 2011 end-page: 332 ident: CR1 article-title: Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs publication-title: Mol Psychiatry doi: 10.1038/mp.2010.14 contributor: fullname: van den Oord – volume: 9 start-page: 273 year: 2006 end-page: 284 ident: CR8 article-title: What is a genetic cause? The example of Alzheimer’s Disease publication-title: Med Health Care Philos doi: 10.1007/s11019-006-9005-7 contributor: fullname: Rikkert – volume: 344 start-page: 241 year: 2005 end-page: 250 ident: CR10 article-title: Identification of two novel human genes, DIPLA1 and DIPAS, expressed in placenta tissue publication-title: Gene doi: 10.1016/j.gene.2004.10.004 contributor: fullname: Castillo – volume: 121 start-page: 183 issue: 2 year: 2014 end-page: 192 ident: CR30 article-title: NRG3 gene is associated with the risk and age at onset of Alzheimer disease publication-title: J Neural Transm. doi: 10.1007/s00702-013-1091-0 contributor: fullname: Xu – volume: 66 start-page: 196 year: 2000 end-page: 204 ident: CR7 article-title: The number of trait loci in late-onset Alzheimer disease publication-title: Am J Hum Genet doi: 10.1086/302710 contributor: fullname: Wijsman – volume: 65 start-page: 1518 year: 2008 end-page: 1526 ident: CR13 article-title: Analyses of the national institute on aging late-onset Alzheimer’s Disease family study: implication of additional loci publication-title: Arch Neurol doi: 10.1001/archneur.65.11.1518 contributor: fullname: Mayeux – volume: 36 start-page: 512 year: 2004 end-page: 517 ident: CR21 article-title: The effects of human population structure on large genetic association studies publication-title: Nat Genet doi: 10.1038/ng1337 contributor: fullname: Donnelly – volume: 65 start-page: 45 year: 2008 ident: 1306_CR16 publication-title: Arch Neurol contributor: fullname: H Li – volume: 83 start-page: 504 year: 2008 ident: 1306_CR27 publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2008.09.011 contributor: fullname: T Vrijenhoek – volume: 44 start-page: 545 year: 2012 ident: 1306_CR4 publication-title: Nat Genet doi: 10.1038/ng.2237 contributor: fullname: JC Bis – volume: 65 start-page: 1518 year: 2008 ident: 1306_CR13 publication-title: Arch Neurol doi: 10.1001/archneur.65.11.1518 contributor: fullname: JH Lee – volume: 9 start-page: 273 year: 2006 ident: 1306_CR8 publication-title: Med Health Care Philos doi: 10.1007/s11019-006-9005-7 contributor: fullname: W Dekkers – volume: 15 start-page: 80 year: 2009 ident: 1306_CR31 publication-title: Neurologist doi: 10.1097/NRL.0b013e318187e76b contributor: fullname: J Williamson – volume: 30 start-page: 8529 year: 2010 ident: 1306_CR32 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0032-10.2010 contributor: fullname: PM Wilson – volume: 81 start-page: 559 year: 2007 ident: 1306_CR24 publication-title: Am J Hum Genet doi: 10.1086/519795 contributor: fullname: S Purcell – ident: 1306_CR17 doi: 10.1126/scitranslmed.3002464 – volume: 121 start-page: 183 issue: 2 year: 2014 ident: 1306_CR30 publication-title: J Neural Transm. doi: 10.1007/s00702-013-1091-0 contributor: fullname: KSXN Wang – volume: 70 start-page: 985 year: 2002 ident: 1306_CR15 publication-title: Am J Hum Genet doi: 10.1086/339815 contributor: fullname: YJ Li – volume: 44 start-page: 724 year: 2009 ident: 1306_CR9 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.10.003 contributor: fullname: N Filippini – volume: 36 start-page: 185 year: 2014 ident: 1306_CR19 publication-title: Brain Dev doi: 10.1016/j.braindev.2013.04.013 contributor: fullname: A Lo-Castro – volume: 22 start-page: 3103 year: 2006 ident: 1306_CR12 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btl507 contributor: fullname: T Hoffmann – volume: 63 start-page: 1307 year: 2006 ident: 1306_CR5 publication-title: Arch Neurol doi: 10.1001/archneur.63.9.1307 contributor: fullname: KL Brickell – volume: 124 start-page: 192 year: 2010 ident: 1306_CR29 publication-title: Schizophr Res doi: 10.1016/j.schres.2010.09.002 contributor: fullname: KS Wang – volume: 105 start-page: 724 year: 2001 ident: 1306_CR23 publication-title: Am J Med Genet doi: 10.1002/ajmg.1608 contributor: fullname: NL Pedersen – volume: 44 start-page: 777 year: 2012 ident: 1306_CR34 publication-title: Nat Genet doi: 10.1038/ng.2307 contributor: fullname: T Freilinger – ident: 1306_CR18 doi: 10.1093/hmg/ddt669 – volume: 52 start-page: 506 year: 1993 ident: 1306_CR26 publication-title: Am J Hum Genet contributor: fullname: RS Spielman – volume: 39 start-page: 436 year: 2012 ident: 1306_CR33 publication-title: Can J Neurol Sci doi: 10.1017/S0317167100013949 contributor: fullname: L Wu – volume: 16 start-page: 321 year: 2011 ident: 1306_CR1 publication-title: Mol Psychiatry doi: 10.1038/mp.2010.14 contributor: fullname: DE Adkins – volume: 107 start-page: 10584 year: 2010 ident: 1306_CR11 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1000274107 contributor: fullname: JT Glessner – volume: 66 start-page: 196 year: 2000 ident: 1306_CR7 publication-title: Am J Hum Genet doi: 10.1086/302710 contributor: fullname: EW Daw – volume: 344 start-page: 241 year: 2005 ident: 1306_CR10 publication-title: Gene doi: 10.1016/j.gene.2004.10.004 contributor: fullname: J Garcia – volume: 34 start-page: 1679 year: 2013 ident: 1306_CR28 publication-title: Hum Mutat doi: 10.1002/humu.22442 contributor: fullname: AT Vulto-van Silfhout – volume: 10 start-page: 231 year: 2008 ident: 1306_CR3 publication-title: Genet Med doi: 10.1097/GIM.0b013e31816b64dc contributor: fullname: TD Bird – volume: 36 start-page: 512 year: 2004 ident: 1306_CR21 publication-title: Nat Genet doi: 10.1038/ng1337 contributor: fullname: J Marchini – volume: 6 start-page: 125 year: 2010 ident: 1306_CR20 publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2010.01.011 contributor: fullname: MW Lutz – volume: 65 start-page: 664 year: 1999 ident: 1306_CR6 publication-title: Am J Hum Genet doi: 10.1086/302553 contributor: fullname: D Campion – volume: 30 start-page: 381 year: 1991 ident: 1306_CR25 publication-title: Ann Neurol doi: 10.1002/ana.410300310 contributor: fullname: WA Rocca – volume: 115 start-page: 1573 year: 2008 ident: 1306_CR14 publication-title: J Neural Transm doi: 10.1007/s00702-008-0119-3 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SubjectTerms | Adult Age of Onset Aged Aged, 80 and over Alzheimer Disease - genetics Canada Genome-Wide Association Study Genotype Glycoproteins - genetics Humans Kaplan-Meier Estimate Linkage Disequilibrium Medicine Medicine & Public Health Middle Aged Nerve Tissue Proteins - genetics Neurology Neurology and Preclinical Neurological Studies - Original Article Neurosciences Polymorphism, Single Nucleotide Psychiatry |
Title | Polymorphisms within ASTN2 gene are associated with age at onset of Alzheimer’s disease |
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