Molecular and cellular physiology of organic cation transporter 2

• Published in: American journal of physiology. Renal physiology Vol. 317; no. 6; pp. F1669 - F1679
• Main Author: Wright, Stephen H.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.12.2019
• Subjects: Animals; Humans; Kidney - cytology; Kidney - metabolism; Organic Cation Transporter 2 - metabolism; Organic Cation Transporter 2 - physiology; Review; kidney; organic cation; transport; kinetics

Organic cation transporters play a critical role in mediating the distribution of cationic pharmaceuticals. Indeed, organic cation transporter (OCT)2 is the initial step in the renal secretion of organic cations and consequently plays a defining role in establishing the pharmacokinetics of many cati...