Human metabolism and renal excretion of selenium compounds after oral ingestion of sodium selenite and selenized yeast dependent on the trimethylselenium ion (TMSe) status

• Published in: Archives of toxicology Vol. 90; no. 5; pp. 1069 - 1080
• Main Authors: Jäger, Thomas, Drexler, Hans, Göen, Thomas
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2016; Springer Nature B.V
• Subjects: Administration, Oral; Adult; Biomarkers - blood; Biomarkers - urine; Biomedical and Life Sciences; Biomedicine; Biotransformation; Dietary Supplements - adverse effects; Environmental Health; Female; Healthy Volunteers; Humans; Inorganic Compounds; Ions; Kidney - metabolism; Kidneys; Male; Metabolism; Middle Aged; Occupational Medicine/Industrial Medicine; Pharmacology/Toxicology; Renal Elimination; Selenium; Selenium Compounds - metabolism; Selenomethionine - adverse effects; Selenomethionine - metabolism; Selenomethionine - pharmacokinetics; Sodium Selenite - administration & dosage; Sodium Selenite - adverse effects; Sodium Selenite - metabolism; Sodium Selenite - pharmacokinetics; Toxicology; Yeast; Yeasts - metabolism; Young Adult; Toxicokinetics; In vivo; Selenium; Human metabolism; Trimethylselenium ion; Speciation

A human in vivo metabolism study was carried out to investigate the impact of the trimethylselenium ion (TMSe) status on metabolism and toxicokinetics of sodium selenite and selenized yeast. Nine healthy human volunteers were orally exposed to 200 µg selenium as sodium selenite and seven with seleni...