Next-generation sequencing diagnostics of bacteremia in pediatric sepsis

• Published in: Medicine (Baltimore) Vol. 100; no. 25; p. e26403
• Main Authors: Schmoch, Thomas, Westhoff, Jens H, Decker, Sebastian O, Skarabis, Annabell, Hoffmann, Georg F, Dohna-Schwake, Christian, Felderhoff-Müser, Ursula, Skolik, Caroline, Feisst, Manuel, Klose, Christina, Bruckner, Thomas, Luntz, Steffen, Weigand, Markus A, Sohn, Kai, Brenner, Thorsten
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 25.06.2021
• Subjects: Anti-Bacterial Agents - therapeutic use; Bacteremia - diagnosis; Bacteremia - drug therapy; Bacteremia - microbiology; Bacteria - genetics; Bacteria - isolation & purification; Blood Culture; Child, Preschool; DNA, Bacterial - isolation & purification; Early Diagnosis; Female; High-Throughput Nucleotide Sequencing; Humans; Infant; Infant, Newborn; Intensive Care Units, Pediatric; Male; Molecular Diagnostic Techniques - methods; Multicenter Studies as Topic; Observational Studies as Topic; Prospective Studies; Retrospective Studies; Severity of Illness Index; Shock, Septic - blood; Shock, Septic - diagnosis; Shock, Septic - drug therapy; Shock, Septic - microbiology; Study Protocol Clinical Trial

Sepsis and septic shock are the most severe forms of infection affecting predominantly elderly people, preterm and term neonates, and young infants. Even in high-income countries sepsis causes about 8% of admissions to pediatric intensive care units (PICUs). Early diagnosis, rapid anti-infective tre...