A Strong Relationship Between Oral Squamous Cell Carcinoma and DNA Repair Genes

• Published in: Biochemical genetics Vol. 55; no. 5-6; pp. 378 - 386
• Main Authors: Avci, Hakan, Ergen, Arzu, Bireller, Elif Sinem, Ertugrul, Baris, Cakmakoglu, Bedia
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2017; Springer Nature B.V
• Subjects: Adult; Aged; Alleles; Amino Acid Substitution; Biochemistry; Biomedical and Life Sciences; Biomedicine; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Deoxyribonucleic acid; DNA; DNA damage; DNA Repair; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Female; Genes; Genetic analysis; heterozygosity; Heterozygotes; Human Genetics; Humans; Male; Medical Microbiology; Middle Aged; Mouth Neoplasms - genetics; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Mutation, Missense; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Oral cancer; Oral squamous cell carcinoma; Original Article; patients; Polymerase chain reaction; Polymorphism; Polymorphism, Restriction Fragment Length; protective effect; Repair; Restriction fragment length polymorphism; Risk analysis; Risk factors; Single-nucleotide polymorphism; Smoking; Smoking - adverse effects; Smoking - metabolism; Squamous cell carcinoma; Turkey; X-radiation; X-ray Repair Cross Complementing Protein 1 - genetics; X-ray Repair Cross Complementing Protein 1 - metabolism; XRCC1 protein; Zoology; XRCC3 Thr241Met; XRCC1 Arg399Gln; Oral squamous cell carcinoma

Single nucleotide polymorphisms of DNA repair genes alter protein function and modulate DNA repair efficiency in various cancers. The X-ray repair cross-complementing group (XRCC) is responsible for the repair of DNA base damage and single-strand breaks. The aim of our study was to investigate the a...