A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment

Ryanodine receptor 2 (RyR2) is a Ca2+ release channel mainly located on the sarcoplasmic reticulum (SR) membrane of heart muscle cells and regulates the concentration of Ca2+ in the cytosol. RyR2 overactivation causes potentially lethal cardiac arrhythmias, but no specific inhibitor is yet available...

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Published inEuropean journal of medicinal chemistry Vol. 262; p. 115910
Main Authors Ishida, Ryosuke, Kurebayashi, Nagomi, Iinuma, Hiroto, Zeng, Xi, Mori, Shuichi, Kodama, Masami, Murayama, Takashi, Masuno, Hiroyuki, Takeda, Fumi, Kawahata, Masatoshi, Tanatani, Aya, Miura, Aya, Nishio, Hajime, Sakurai, Takashi, Kagechika, Hiroyuki
Format Journal Article
LanguageEnglish
Published ISSY-LES-MOULINEAUX Elsevier Masson SAS 15.12.2023
Elsevier
Subjects
Arrhythmias drug candidate
Ca2+ channel inhibitor
Chemistry, Medicinal
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Ryanodine receptor 2
Science & Technology
Structure-activity relationship
Arrhythmias drug candidate
Ryanodine receptor 2
Ca2+ channel inhibitor
Structure-activity relationship
POLYMORPHIC VENTRICULAR-TACHYCARDIA
TETRAZOLES
DANTROLENE
MALIGNANT HYPERTHERMIA
CONVERSION
SARCOPLASMIC-RETICULUM
RELEASE CHANNEL
PHARMACOLOGY
Ca 2+channel inhibitor
MOUSE MODEL
MUTATIONS
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Abstract Ryanodine receptor 2 (RyR2) is a Ca2+ release channel mainly located on the sarcoplasmic reticulum (SR) membrane of heart muscle cells and regulates the concentration of Ca2+ in the cytosol. RyR2 overactivation causes potentially lethal cardiac arrhythmias, but no specific inhibitor is yet available. Herein we developed the first highly potent and selective RyR2 inhibitor, TMDJ-035, containing 3,5-difluoro substituents on the A ring and a 4-fluoro substituent on the B ring, based on a comprehensive structure-activity relationship (SAR) study of tetrazole compound 1. The SAR study also showed that the amide conformation is critical for inhibitory potency. Single-crystal X-ray diffraction analysis and variable-temperature 1H NMR revealed that TMDJ-035 strongly favors cis-amide configuration, while the inactive analogue TMDJ-011 with a secondary amide takes trans-amide configuration. Examination of the selectivity among RyRs indicated that TMDJ-035 displayed high selectivity for RyR2. TMDJ-035 suppressed abnormal Ca2+ waves and transients in isolated cardiomyocytes from RyR2-mutated mice. It appears to be a promising candidate drug for treating cardiac arrhythmias due to RyR2 overactivation, as well as a tool for studying the mechanism and dynamics of RyR2 channel gating. TMDJ-035 with cis-amide configuration could suppress abnormal Ca2+ signals in cardiomyocytes from RyR2-mutated mice. [Display omitted] •The novel RyR2 selective inhibitor 1 was identified.•Structure-activity relationship discovered quite potent RyR2 inhibitor TMDJ-035.•The amide conformation of TMDJ-035 was verified as cis-amide, which is crucial for the activity expression.•TMDJ-035 showed complete selectivity among RyRs.•TMDJ-035 could suppress the abnormal Ca2+ signals in cardiomyocytes from RyR2-mutated mice.
AbstractList Ryanodine receptor 2 (RyR2) is a Ca2+ release channel mainly located on the sarcoplasmic reticulum (SR) membrane of heart muscle cells and regulates the concentration of Ca2+ in the cytosol. RyR2 overactivation causes potentially lethal cardiac arrhythmias, but no specific inhibitor is yet available. Herein we developed the first highly potent and selective RyR2 inhibitor, TMDJ-035, containing 3,5-difluoro substituents on the A ring and a 4-fluoro substituent on the B ring, based on a comprehensive structure-activity relationship (SAR) study of tetrazole compound 1. The SAR study also showed that the amide conformation is critical for inhibitory potency. Single-crystal X-ray diffraction analysis and variable-temperature 1H NMR revealed that TMDJ-035 strongly favors cis-amide configuration, while the inactive analogue TMDJ-011 with a secondary amide takes trans-amide configuration. Examination of the selectivity among RyRs indicated that TMDJ-035 displayed high selectivity for RyR2. TMDJ-035 suppressed abnormal Ca2+ waves and transients in isolated cardiomyocytes from RyR2-mutated mice. It appears to be a promising candidate drug for treating cardiac arrhythmias due to RyR2 overactivation, as well as a tool for studying the mechanism and dynamics of RyR2 channel gating. TMDJ-035 with cis-amide configuration could suppress abnormal Ca2+ signals in cardiomyocytes from RyR2-mutated mice. [Display omitted] •The novel RyR2 selective inhibitor 1 was identified.•Structure-activity relationship discovered quite potent RyR2 inhibitor TMDJ-035.•The amide conformation of TMDJ-035 was verified as cis-amide, which is crucial for the activity expression.•TMDJ-035 showed complete selectivity among RyRs.•TMDJ-035 could suppress the abnormal Ca2+ signals in cardiomyocytes from RyR2-mutated mice.
Ryanodine receptor 2 (RyR2) is a Ca2+ release channel mainly located on the sarcoplasmic reticulum (SR) membrane of heart muscle cells and regulates the concentration of Ca2+ in the cytosol. RyR2 overactivation causes potentially lethal cardiac arrhythmias, but no specific inhibitor is yet available. Herein we developed the first highly potent and selective RyR2 inhibitor, TMDJ-035, containing 3,5-difluoro substituents on the A ring and a 4-fluoro substituent on the B ring, based on a comprehensive structure-activity relationship (SAR) study of tetrazole compound 1. The SAR study also showed that the amide conformation is critical for inhibitory potency. Single-crystal X-ray diffraction analysis and variable-temperature 1H NMR revealed that TMDJ-035 strongly favors cis-amide configuration, while the inactive analogue TMDJ-011 with a secondary amide takes trans-amide configuration. Examination of the selectivity among RyRs indicated that TMDJ-035 displayed high selectivity for RyR2. TMDJ-035 suppressed abnormal Ca2+ waves and transients in isolated cardiomyocytes from RyR2-mutated mice. It appears to be a promising candidate drug for treating cardiac arrhythmias due to RyR2 over-activation, as well as a tool for studying the mechanism and dynamics of RyR2 channel gating.
Ryanodine receptor 2 (RyR2) is a Ca2+ release channel mainly located on the sarcoplasmic reticulum (SR) membrane of heart muscle cells and regulates the concentration of Ca2+ in the cytosol. RyR2 overactivation causes potentially lethal cardiac arrhythmias, but no specific inhibitor is yet available. Herein we developed the first highly potent and selective RyR2 inhibitor, TMDJ-035, containing 3,5-difluoro substituents on the A ring and a 4-fluoro substituent on the B ring, based on a comprehensive structure-activity relationship (SAR) study of tetrazole compound 1. The SAR study also showed that the amide conformation is critical for inhibitory potency. Single-crystal X-ray diffraction analysis and variable-temperature 1H NMR revealed that TMDJ-035 strongly favors cis-amide configuration, while the inactive analogue TMDJ-011 with a secondary amide takes trans-amide configuration. Examination of the selectivity among RyRs indicated that TMDJ-035 displayed high selectivity for RyR2. TMDJ-035 suppressed abnormal Ca2+ waves and transients in isolated cardiomyocytes from RyR2-mutated mice. It appears to be a promising candidate drug for treating cardiac arrhythmias due to RyR2 overactivation, as well as a tool for studying the mechanism and dynamics of RyR2 channel gating.
ArticleNumber 115910
Author Ishida, Ryosuke
Mori, Shuichi
Kawahata, Masatoshi
Nishio, Hajime
Sakurai, Takashi
Takeda, Fumi
Kagechika, Hiroyuki
Kodama, Masami
Masuno, Hiroyuki
Murayama, Takashi
Kurebayashi, Nagomi
Iinuma, Hiroto
Miura, Aya
Zeng, Xi
Tanatani, Aya
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  surname: Ishida
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  organization: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), Tokyo, 101-0062, Japan
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  givenname: Nagomi
  surname: Kurebayashi
  fullname: Kurebayashi, Nagomi
  email: nagomik@juntendo.ac.jp
  organization: Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan
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  givenname: Hiroto
  surname: Iinuma
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  organization: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), Tokyo, 101-0062, Japan
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  givenname: Xi
  surname: Zeng
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  givenname: Takashi
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  fullname: Murayama, Takashi
  organization: Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan
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  givenname: Hiroyuki
  surname: Masuno
  fullname: Masuno, Hiroyuki
  organization: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), Tokyo, 101-0062, Japan
– sequence: 9
  givenname: Fumi
  surname: Takeda
  fullname: Takeda, Fumi
  organization: Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo, 112-8610, Japan
– sequence: 10
  givenname: Masatoshi
  surname: Kawahata
  fullname: Kawahata, Masatoshi
  organization: Faculty of Pharmaceutical Sciences, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo, 194-8543, Japan
– sequence: 11
  givenname: Aya
  surname: Tanatani
  fullname: Tanatani, Aya
  organization: Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo, 112-8610, Japan
– sequence: 12
  givenname: Aya
  surname: Miura
  fullname: Miura, Aya
  organization: Department of Legal Medicine, Hyogo Medical University, Nishinomiya, 663-8501, Japan
– sequence: 13
  givenname: Hajime
  surname: Nishio
  fullname: Nishio, Hajime
  organization: Department of Legal Medicine, Hyogo Medical University, Nishinomiya, 663-8501, Japan
– sequence: 14
  givenname: Takashi
  surname: Sakurai
  fullname: Sakurai, Takashi
  organization: Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan
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  givenname: Hiroyuki
  orcidid: 0000-0002-6747-1013
  surname: Kagechika
  fullname: Kagechika, Hiroyuki
  email: kage.chem@tmd.ac.jp
  organization: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), Tokyo, 101-0062, Japan
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Cites_doi 10.1002/cpph.71
10.1016/j.tibs.2014.10.005
10.1002/humu.20356
10.1152/physrev.00013.2002
10.1101/cshperspect.a003996
10.1016/j.jelectrocard.2021.09.015
10.1007/s00210-003-0860-y
10.1016/j.bbrc.2014.08.132
10.1016/j.jacc.2009.08.022
10.1016/j.str.2022.04.010
10.1016/j.coph.2023.102356
10.1253/circj.CJ-16-0250
10.1042/BJ20041336
10.1371/journal.pone.0095615
10.1093/bja/aep204
10.1161/01.CIR.0000020013.73106.D8
10.1016/j.ejmech.2019.06.076
10.1016/j.jacc.2011.01.026
10.1085/jgp.202112869
10.1038/ncomms5153
10.1016/j.bmc.2010.04.047
10.1161/CIRCEP.112.970517
10.1038/nature01780
10.1124/molpharm.123.000720
10.1016/j.hrthm.2006.08.018
10.1124/mol.117.111468
10.1111/j.1540-8167.2008.01211.x
10.1002/anie.200701045
10.1016/j.jacc.2009.01.065
10.1021/acs.joc.6b02277
10.1161/CIRCULATIONAHA.115.015731
10.1161/CIRCRESAHA.110.227744
10.1085/jgp.201611624
10.1161/01.RES.0000252828.17939.00
10.1016/j.jacc.2020.12.073
10.1007/s10974-020-09575-6
10.1016/j.yjmcc.2011.05.009
10.2170/physiolsci.RP010107
10.1038/s10038-020-0738-6
10.1002/ejoc.201100957
10.1038/s41467-022-30429-x
10.1111/anec.12512
10.1016/j.pharmthera.2005.04.003
10.1107/S2053229614024218
10.1161/CIRCRESAHA.120.316819
10.3390/ijms21155584
10.1016/j.bmc.2022.117027
10.1038/240217a0
10.1073/pnas.82.21.7256
10.1021/jm00130a011
10.1021/ja00052a078
10.1107/S2053273314026370
10.1016/S0021-9258(18)47774-5
10.1074/jbc.272.42.26332
10.1111/j.1365-2044.2004.03658.x
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Keywords Arrhythmias drug candidate
Ryanodine receptor 2
Ca2+ channel inhibitor
Structure-activity relationship
POLYMORPHIC VENTRICULAR-TACHYCARDIA
TETRAZOLES
DANTROLENE
MALIGNANT HYPERTHERMIA
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Ca 2+channel inhibitor
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References Takeda, Yamashita, Maeda, Maéda (bib2) 2003; 424
Paul-Pletzer, Yamamoto, Ikemoto, Jimenez, Morimoto, Williams, Ma, Parness (bib28) 2005; 387
Suzuki, Kanemaru, Ishii, Ohkura, Okubo, Iino (bib52) 2014; 5
Medeiros-Domingo, Bhuiyan, Tester, Hofman, Bikker, van Tintelen, Mannens, Wilde, Ackerman (bib19) 2009; 54
Fill, Copello (bib5) 2002; 82
Murayama, Kurebayashi (bib54) 2019; 87
Sheldrick (bib46) 2015; 71
Yano, Yamamoto, Ikemoto, Matsuzaki (bib15) 2005; 107
Murayama, Kurebayashi, Ishida, Kagechika (bib13) 2023; 69
Okudaira, Kuwahara, Hirata, Oku, Nishio (bib43) 2014; 452
Inui, Saito, Fleischer (bib4) 1987; 262
chen Bai, McMullan, Scheres (bib33) 2015; 40
Itai, Toriumi, Saito, Kagechika, Shudo (bib38) 1992; 114
Tong, Oyamada, Demaurex, Grinstein, McCarthy, MacLennan (bib53) 1997; 272
Lanner, Georgiou, Joshi, Hamilton (bib6) 2010; 2
Robinson, Carpenter, Shaw, Halsall, Hopkins (bib8) 2006; 27
Kobayashi, Tsutsumi, Kurebayash, Saito, Kodama, Sakurai, Kikkawa, Murayama, Ogawa (bib34) 2022; 13
Sheldrick (bib47) 2015; 71
Mohamed, Gollob, Gow, Krahn (bib24) 2006; 3
van der Werf, Nederend, Hofman, van Geloven, Ebink, Frohn-Mulder, Alings, Bosker, Bracke, van den Heuvel, Waalewijn, Bikker, van Tintelen, Bhuiyan, van den Berg, Wilde (bib27) 2012; 5
Takenaka, Kodama, Murayama, Ishigami-Yuasa, Mori, Ishida, Suzuki, Kanemaru, Sugihara, Iino, Miura, Nishio, Morimoto, Kagechika, Sakurai, Kurebayashi (bib32) 2023
Ebashi (bib1) 1972; 240
Shioya (bib55) 2007; 57
Melville, Dridi, Yuan, Reiken, Wronska, Liu, Clarke, Marks (bib35) 2022; 30
Pérez-Riera, Barbosa-Barros (bib21) 2018; 23
Kagechika, Himi, Kawachi, Hashimoto, Shudo (bib39) 1992; 32
Kawata, Ohno, Aiba, Sakaguchi, Miyazaki, Sumitomo, Kamakura, Nakajima, Inoue, Miyamoto, Okamura, Noda, Kusano, Kamakura, Miyamoto, Shiraishi, Horie, Shimizu (bib18) 2016; 80
Kurebayashi, Murayama, Ota, Suzuki, Kanemar, Kobayashi, Ohno, Horie, Iino, Yamashita, Sakurai (bib20) 2022; 154
Ogawa, Kurebayashi, Yamazawa, Murayama (bib7) 2021; 42
Murayama, Kurebayashi, Ishigami-Yuasa, Mori, Suzuki, Akima, Ogawa, Suzuki, Kanemaru, Oyamada, Kiuchi, Iino, Kagechika, Sakurai (bib36) 2018; 94
Uehara, Murayama, Yasukochi, Fill, Horie, Okamoto, Matsuura, Uehara, Fujimoto, Sakurai, Kurebayashi (bib37) 2018; 149
Ishida, Mori, Murayama, Nakamichi, Chai, Kurebayashi, Iinuma, Kagechika (bib12) 2022; 74
Aureggi, Sedelmeier (bib50) 2007; 46
De Ferrari, Dusi, Spazzolini, DVM, Bos, Abrams, Berul, Crotti, Davis, Eldar, Kharlap, Khoury, Krahn, Leenhardt, Moir, Odero, Nordkamp, Paul, i Noguer, Shkolnikova, Till, Wilde, Ackerman, Schwartz (bib22) 2015; 131
Itoh, Murayama, Kurebayashi, Ohno, Kobayashi, Fujii, Watanabe, Ogawa, Anzai, Horie (bib26) 2021; 69
Koga, Negishi, Kinoshita, Fujii, Mori, Ishigami-Yuasa, Kawachi, Kagechika, Tanatani (bib40) 2020; 21
Fleischer, Ogunbunmi, Dixon, Fleer (bib3) 1985; 82
Kryshtal, Blackwell, Egly, Smith, Batiste, Johnston, Laver, Knollmann (bib31) 2021; 1228
Vignesh, Bhuvanesh, Dharmaraj (bib49) 2017; 82
Laver, van Helden (bib30) 2011; 51
Olubando, Hopton, Eden, Caswell, Thomas, Roberts, Morris-Rosendahl, Venetucci, Newman (bib14) 2020; 65
Priori, Napolitano, Memmi, Colombi, Drago, Gasparini, DeSimone, Coltorti, Bloise, Keegan, Cruz Filho, Vignati, Benatar, DeLogu (bib16) 2002; 106
Mori, Iinuma, Manaka, Ishigami-Yuasa, Murayama, Nishijima, Sakurai, Ara, Kurebayash, Sakurai, Kagechika (bib11) 2019; 179
Lamoral-Theys, Pottier, Kerff, Dufrasne, Proutière, Wauthoz, Neven, Ingrassia, Antwerpen, Lefranc, Gelbcke, Pirotte, Kraus, Nève, Kornienko, Kiss, Dubois (bib51) 2010; 18
Carpenter, Robinson, Quinnel, Ringrose, Hogg, Casson, Booms, Iles, Halsall, Steele, Shaw, Hopkins (bib9) 2009; 103
Krause, Gerbershagen, Fiege, Weißhorn1, Wappler (bib10) 2004; 59
Kashimura, Briston, Trafford, Napolitano, Priori, Eisner, Venetucci (bib41) 2010; 107
Priori, Mazzanti, Santiago, Kukavica, Trancuccio, Kovacic (bib17) 2021; 77
Aridoss, Laali (bib48) 2011
Liu, Wang, Sun, Mi1, Zhang, Mu, Chen, Bround, Johnson, Gillis, Chen (bib42) 2014; 9
Hoffmann, Leitz, Oberdorf-Maass, Lohse, Klotz (bib45) 2004; 369
Kobayashi, Yano, Suetomi, Ono, Tateishi, Mochizuki, Xu, Uchinoumi, Okuda, Yamamoto, Koseki, Kyushiki, Ikemoto, Matsuzak (bib29) 2009; 53
Venetucci, Trafford, Eisner (bib44) 2007; 100
Pizzale, Gollob, Gow, Birnie (bib25) 2008; 19
van der Werf, Kannankeril, Sacher, Krahn, Viskin, Leenhardt, Shimizu, Sumitomo, Fish, Bhuiyan, Willems, van der Veen, Watanabe, Laborderie, Haïssaguerre, Knollmann, Wilde (bib23) 2011; 57
Pérez-Riera, AR (WOS:000437669400003) 2018; 23
Koga, H (WOS:000559043000001) 2020; 21
Ogawa, H (WOS:000516063600001) 2021; 42
De Ferrari, GM (WOS:000360528400005) 2015; 131
Murayama, Takashi (MEDLINE:31834676) 2019; 87
Priori, SG (WOS:000653014000012) 2021; 77
Lamoral-Theys, D (WOS:000278078600024) 2010; 18
Kurebayashi, N (WOS:000868238500001) 2022; 154
Kawata, H (WOS:000383804700010) 2016; 80
Medeiros-Domingo, A (WOS:000271902500013) 2009; 54
van der Werf, C (WOS:000313584500023) 2012; 5
Bai, XC (WOS:000347862900007) 2015; 40
Mori, S (WOS:000486133100062) 2019; 179
Murayama, T (WOS:000435118700006) 2018; 94
Lanner, JT (WOS:000283646900004) 2010; 2
Krause, T (WOS:000220257700011) 2004; 59
Tong, JF (WOS:A1997YB13900039) 1997; 272
Pizzale, S (WOS:000261204100023) 2008; 19
Kobayashi, T (WOS:000799632400026) 2022; 13
INUI, M (WOS:A1987K886800051) 1987; 262
Olubando, D (WOS:000518733200001) 2020; 65
Sheldrick, GM (WOS:000347804100002) 2015; 71
KAGECHIKA, H (WOS:A1989AT15000011) 1989; 32
Venetucci, LA (WOS:000243407300015) 2007; 100
Shioya, T (WOS:000252934300001) 2007; 57
Kobayashi, S (WOS:000266236800010) 2009; 53
Takeda, S (WOS:000183912800031) 2003; 424
Fill, M (WOS:000178146000003) 2002; 82
Vignesh, A (WOS:000392569500005) 2017; 82
Robinson, R (WOS:000240410300001) 2006; 27
Kashimura, T (WOS:000285143000011) 2010; 107
Aureggi, V (WOS:000250990000024) 2007; 46
Laver, DR (WOS:000294315400010) 2011; 51
Hoffmann, C (WOS:000188836400002) 2004; 369
Ishida, R (WOS:000918048100006) 2022; 74
Suzuki, J (WOS:000338838500009) 2014; 5
Okudaira, N (WOS:000343023900058) 2014; 452
Yano, M (WOS:000231750800007) 2005; 107
Takenaka, M (WOS:001109943800004) 2023; 104
Priori, SG (WOS:000176820400016) 2002; 106
Kryshtal, DO (WOS:000639316800004) 2021; 128
Carpenter, D (WOS:000269735400013) 2009; 103
ITAI, A (WOS:A1992KD71700078) 1992; 114
Melville, Z (WOS:000827591300002) 2022; 30
Uehara, A (WOS:000394254300005) 2017; 149
van der Werf, C (WOS:000291006400006) 2011; 57
Itoh, H (WOS:000768195700021) 2021; 69
EBASHI, S (WOS:A1972O069400035) 1972; 240
Mohamed, U (WOS:000242860800015) 2006; 3
FLEISCHER, S (WOS:A1985AUF2900022) 1985; 82
Murayama, T (WOS:000948422800001) 2023; 69
Liu, YJ (WOS:000335309100146) 2014; 9
Aridoss, G (WOS:000296319000023) 2011; 2011
Paul-Pletzer, K (WOS:000229135600040) 2005; 387
Pérez-Riera (10.1016/j.ejmech.2023.115910_bib21) 2018; 23
Vignesh (10.1016/j.ejmech.2023.115910_bib49) 2017; 82
Kobayashi (10.1016/j.ejmech.2023.115910_bib29) 2009; 53
Uehara (10.1016/j.ejmech.2023.115910_bib37) 2018; 149
Liu (10.1016/j.ejmech.2023.115910_bib42) 2014; 9
Murayama (10.1016/j.ejmech.2023.115910_bib13) 2023; 69
Aureggi (10.1016/j.ejmech.2023.115910_bib50) 2007; 46
Pizzale (10.1016/j.ejmech.2023.115910_bib25) 2008; 19
Priori (10.1016/j.ejmech.2023.115910_bib17) 2021; 77
Kurebayashi (10.1016/j.ejmech.2023.115910_bib20) 2022; 154
Kobayashi (10.1016/j.ejmech.2023.115910_bib34) 2022; 13
Kryshtal (10.1016/j.ejmech.2023.115910_bib31) 2021; 1228
Tong (10.1016/j.ejmech.2023.115910_bib53) 1997; 272
Melville (10.1016/j.ejmech.2023.115910_bib35) 2022; 30
Murayama (10.1016/j.ejmech.2023.115910_bib54) 2019; 87
Okudaira (10.1016/j.ejmech.2023.115910_bib43) 2014; 452
Medeiros-Domingo (10.1016/j.ejmech.2023.115910_bib19) 2009; 54
Sheldrick (10.1016/j.ejmech.2023.115910_bib46) 2015; 71
Itoh (10.1016/j.ejmech.2023.115910_bib26) 2021; 69
Fleischer (10.1016/j.ejmech.2023.115910_bib3) 1985; 82
Lamoral-Theys (10.1016/j.ejmech.2023.115910_bib51) 2010; 18
Ebashi (10.1016/j.ejmech.2023.115910_bib1) 1972; 240
Koga (10.1016/j.ejmech.2023.115910_bib40) 2020; 21
Kashimura (10.1016/j.ejmech.2023.115910_bib41) 2010; 107
Yano (10.1016/j.ejmech.2023.115910_bib15) 2005; 107
Shioya (10.1016/j.ejmech.2023.115910_bib55) 2007; 57
Kagechika (10.1016/j.ejmech.2023.115910_bib39) 1992; 32
Lanner (10.1016/j.ejmech.2023.115910_bib6) 2010; 2
van der Werf (10.1016/j.ejmech.2023.115910_bib23) 2011; 57
chen Bai (10.1016/j.ejmech.2023.115910_bib33) 2015; 40
Ishida (10.1016/j.ejmech.2023.115910_bib12) 2022; 74
Venetucci (10.1016/j.ejmech.2023.115910_bib44) 2007; 100
Hoffmann (10.1016/j.ejmech.2023.115910_bib45) 2004; 369
Kawata (10.1016/j.ejmech.2023.115910_bib18) 2016; 80
Carpenter (10.1016/j.ejmech.2023.115910_bib9) 2009; 103
Takeda (10.1016/j.ejmech.2023.115910_bib2) 2003; 424
Krause (10.1016/j.ejmech.2023.115910_bib10) 2004; 59
Paul-Pletzer (10.1016/j.ejmech.2023.115910_bib28) 2005; 387
Mori (10.1016/j.ejmech.2023.115910_bib11) 2019; 179
Sheldrick (10.1016/j.ejmech.2023.115910_bib47) 2015; 71
Takenaka (10.1016/j.ejmech.2023.115910_bib32) 2023
Aridoss (10.1016/j.ejmech.2023.115910_bib48) 2011
Mohamed (10.1016/j.ejmech.2023.115910_bib24) 2006; 3
Suzuki (10.1016/j.ejmech.2023.115910_bib52) 2014; 5
Fill (10.1016/j.ejmech.2023.115910_bib5) 2002; 82
Laver (10.1016/j.ejmech.2023.115910_bib30) 2011; 51
Ogawa (10.1016/j.ejmech.2023.115910_bib7) 2021; 42
Priori (10.1016/j.ejmech.2023.115910_bib16) 2002; 106
De Ferrari (10.1016/j.ejmech.2023.115910_bib22) 2015; 131
van der Werf (10.1016/j.ejmech.2023.115910_bib27) 2012; 5
Itai (10.1016/j.ejmech.2023.115910_bib38) 1992; 114
Murayama (10.1016/j.ejmech.2023.115910_bib36) 2018; 94
Robinson (10.1016/j.ejmech.2023.115910_bib8) 2006; 27
Olubando (10.1016/j.ejmech.2023.115910_bib14) 2020; 65
Inui (10.1016/j.ejmech.2023.115910_bib4) 1987; 262
References_xml – volume: 46
  start-page: 8440
  year: 2007
  end-page: 8444
  ident: bib50
  article-title: 1,3-Dipolar cycloaddition: click chemistry for the synthesis of 5-substituted tetrazoles from organoaluminum azides and nitriles
  publication-title: Angew. Chem. Int. Ed.
  contributor:
    fullname: Sedelmeier
– volume: 5
  start-page: 4153
  year: 2014
  ident: bib52
  article-title: Imaging intraorganellar Ca
  publication-title: Nat. Commun.
  contributor:
    fullname: Iino
– volume: 13
  start-page: 2821
  year: 2022
  ident: bib34
  article-title: Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations
  publication-title: Nat. Commun.
  contributor:
    fullname: Ogawa
– volume: 57
  start-page: 2244
  year: 2011
  end-page: 2254
  ident: bib23
  article-title: Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia
  publication-title: J. Am. Coll. Cardiol.
  contributor:
    fullname: Wilde
– volume: 179
  start-page: 837e848
  year: 2019
  ident: bib11
  article-title: Structural development of a type-1 ryanodine receptor (RyR1) Ca
  publication-title: Eur. J. Med. Chem.
  contributor:
    fullname: Kagechika
– volume: 71
  start-page: 3
  year: 2015
  end-page: 8
  ident: bib47
  article-title: Crystal structure refinement with SHELXL
  publication-title: Acta Crystallogr., Sect. C: Struct. Chem.
  contributor:
    fullname: Sheldrick
– volume: 114
  start-page: 10649
  year: 1992
  end-page: 10650
  ident: bib38
  article-title: Preference for cis-amide structure in N-acyl-N-methylanilines
  publication-title: J. Am. Chem. Soc.
  contributor:
    fullname: Shudo
– volume: 69
  year: 2023
  ident: bib13
  article-title: Drug development for the treatment of RyR1-related skeletal muscle diseases
  publication-title: Curr. Opin. Pharmacol.
  contributor:
    fullname: Kagechika
– volume: 131
  start-page: 2185
  year: 2015
  end-page: 2193
  ident: bib22
  article-title: Clinical management of catecholaminergic polymorphic ventricular tachycardia
  publication-title: Circulation
  contributor:
    fullname: Schwartz
– volume: 369
  start-page: 151
  year: 2004
  end-page: 159
  ident: bib45
  article-title: Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cells
  publication-title: Naunyn-Schmiedeberg’s Arch. Pharmacol.
  contributor:
    fullname: Klotz
– volume: 106
  start-page: 69
  year: 2002
  end-page: 74
  ident: bib16
  article-title: Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia
  publication-title: Circulation
  contributor:
    fullname: DeLogu
– volume: 23
  year: 2018
  ident: bib21
  article-title: Catecholaminergic polymorphic ventricular tachycardia, an update
  publication-title: Ann. Noninvasive Electrocardiol.
  contributor:
    fullname: Barbosa-Barros
– volume: 32
  start-page: 2292
  year: 1992
  end-page: 2296
  ident: bib39
  article-title: Retinobenzoic acids. 4. Conformation of aromatic amides with retinoidal activity. Importance of trans-amide structure for the activity
  publication-title: J. Med. Chem.
  contributor:
    fullname: Shudo
– volume: 5
  start-page: 748
  year: 2012
  end-page: 756
  ident: bib27
  article-title: Familial evaluation in catecholaminergic polymorphic ventricular tachycardia
  publication-title: Circ. Arrhythm. Electrophysiol.
  contributor:
    fullname: Wilde
– volume: 80
  start-page: 1907
  year: 2016
  end-page: 1915
  ident: bib18
  article-title: Catecholaminergic polymorphic ventricular tachycardia (CPVT) associated with ryanodine receptor (RyR2) gene mutations
  publication-title: Circ. J.
  contributor:
    fullname: Shimizu
– volume: 71
  start-page: 3
  year: 2015
  end-page: 8
  ident: bib46
  article-title: SHELXT - integrated space-group and crystal-structure determination
  publication-title: Acta Crystallogr., Sect. A: Found. Adv.
  contributor:
    fullname: Sheldrick
– volume: 107
  start-page: 1483
  year: 2010
  end-page: 1489
  ident: bib41
  article-title: In the RyR2R4496C mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves
  publication-title: Circ. Res.
  contributor:
    fullname: Venetucci
– volume: 69
  start-page: 111
  year: 2021
  end-page: 118
  ident: bib26
  article-title: Sudden death after inappropriate shocks of implantable cardioverter defibrillator in a catecholaminergic polymorphic ventricular tachycardia case with a novel RyR2 mutation
  publication-title: J. Electrocardiol.
  contributor:
    fullname: Horie
– volume: 21
  start-page: 5584
  year: 2020
  ident: bib40
  article-title: Development of androgen-antagonistic coumarinamides with a unique aromatic folded pharmacophore
  publication-title: Int. J. Mol. Sci.
  contributor:
    fullname: Tanatani
– volume: 107
  start-page: 377
  year: 2005
  end-page: 391
  ident: bib15
  article-title: Abnormal ryanodine receptor function in heart failure
  publication-title: Pharmacol. Ther.
  contributor:
    fullname: Matsuzaki
– volume: 100
  start-page: 105
  year: 2007
  end-page: 111
  ident: bib44
  article-title: Increasing ryanodine receptor open probability alone does not produce arrhythmogenic calcium waves
  publication-title: Circ. Res.
  contributor:
    fullname: Eisner
– volume: 2
  year: 2010
  ident: bib6
  article-title: Ryanodine receptors: structure, expression, molecular details, and function in calcium release
  publication-title: Cold Spring Harbor Perspect. Biol.
  contributor:
    fullname: Hamilton
– volume: 77
  start-page: 2592
  year: 2021
  end-page: 2612
  ident: bib17
  article-title: Precision medicine in catecholaminergic polymorphic ventricular tachycardia: JACC focus seminar 5/5
  publication-title: J. Am. Coll. Cardiol.
  contributor:
    fullname: Kovacic
– volume: 30
  start-page: 1025
  year: 2022
  end-page: 1034
  ident: bib35
  article-title: A drug and ATP binding site in type 1 ryanodine receptor
  publication-title: Structure
  contributor:
    fullname: Marks
– volume: 1228
  start-page: 321
  year: 2021
  end-page: 331
  ident: bib31
  article-title: RYR2 channel inhibition is the principal mechanism of flecainide action in CPVT
  publication-title: Circ. Res.
  contributor:
    fullname: Knollmann
– start-page: 6343
  year: 2011
  end-page: 6355
  ident: bib48
  article-title: Highly efficient synthesis of 5-substituted 1
  publication-title: Eur. J. Org. Chem.
  contributor:
    fullname: Laali
– volume: 87
  start-page: e71
  year: 2019
  ident: bib54
  article-title: Assays for modulators of ryanodine receptor (RyR)/Ca
  publication-title: Curr. Protoc. Pharmacol.
  contributor:
    fullname: Kurebayashi
– volume: 240
  start-page: 217
  year: 1972
  end-page: 218
  ident: bib1
  article-title: Calcium ions and muscle contraction
  publication-title: Nature
  contributor:
    fullname: Ebashi
– volume: 82
  start-page: 893
  year: 2002
  end-page: 922
  ident: bib5
  article-title: Ryanodine receptor calcium release channels
  publication-title: Physiol. Rev.
  contributor:
    fullname: Copello
– volume: 9
  year: 2014
  ident: bib42
  article-title: Generation and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor
  publication-title: PLoS One
  contributor:
    fullname: Chen
– volume: 103
  start-page: 538
  year: 2009
  end-page: 548
  ident: bib9
  article-title: Genetic variation in RYR1 and malignant hyperthermia phenotypes
  publication-title: Br. J. Anaesth.
  contributor:
    fullname: Hopkins
– volume: 18
  start-page: 3823
  year: 2010
  end-page: 3833
  ident: bib51
  article-title: Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli
  publication-title: Bioorg. Med. Chem.
  contributor:
    fullname: Dubois
– volume: 82
  start-page: 7256
  year: 1985
  end-page: 7259
  ident: bib3
  article-title: Localization of Ca
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  contributor:
    fullname: Fleer
– volume: 65
  start-page: 531
  year: 2020
  end-page: 539
  ident: bib14
  article-title: Classification and correlation of RYR2 missense variants in individuals with catecholaminergic polymorphic ventricular tachycardia reveals phenotypic relationships
  publication-title: J. Hum. Genet.
  contributor:
    fullname: Newman
– volume: 94
  start-page: 722
  year: 2018
  end-page: 730
  ident: bib36
  article-title: Efficient high-throughput screening by endoplasmic reticulum Ca
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: Sakurai
– volume: 74
  year: 2022
  ident: bib12
  article-title: Development of a water-soluble ryanodine receptor 1 inhibitor
  publication-title: Bioorg. Med. Chem.
  contributor:
    fullname: Kagechika
– volume: 272
  start-page: 26332
  year: 1997
  end-page: 26339
  ident: bib53
  article-title: Caffeine and halothane sensitivity of intracellular Ca
  publication-title: J. Biol. Chem.
  contributor:
    fullname: MacLennan
– volume: 154
  year: 2022
  ident: bib20
  article-title: Cytosolic Ca
  publication-title: J. Gen. Physiol.
  contributor:
    fullname: Sakurai
– volume: 452
  start-page: 665
  year: 2014
  end-page: 668
  ident: bib43
  article-title: A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes
  publication-title: Biochem. Biophys. Res. Commun.
  contributor:
    fullname: Nishio
– volume: 424
  start-page: 35
  year: 2003
  end-page: 41
  ident: bib2
  article-title: Structure of the core domain of human cardiac troponin in the Ca
  publication-title: Nature
  contributor:
    fullname: Maéda
– volume: 82
  start-page: 887
  year: 2017
  end-page: 892
  ident: bib49
  article-title: Conversion of arylboronic acids to tetrazoles catalyzed by ONO pincer-type palladium complex
  publication-title: J. Org. Chem.
  contributor:
    fullname: Dharmaraj
– volume: 262
  start-page: 15637
  year: 1987
  end-page: 15642
  ident: bib4
  article-title: Isolation of the ryanodine receptor from cardiac sarcoplasmic reticulum and identity with the feet structures
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Fleischer
– volume: 149
  start-page: 199
  year: 2018
  end-page: 218
  ident: bib37
  article-title: Extensive Ca
  publication-title: J. Gen. Physiol.
  contributor:
    fullname: Kurebayashi
– volume: 40
  start-page: 49
  year: 2015
  end-page: 57
  ident: bib33
  article-title: How cryo-EM is revolutionizing structural biology
  publication-title: Trends Biochem. Sci.
  contributor:
    fullname: Scheres
– volume: 387
  start-page: 905
  year: 2005
  end-page: 909
  ident: bib28
  article-title: Probing a putative dantrolene-binding site on the cardiac ryanodine receptor
  publication-title: Biochem. J.
  contributor:
    fullname: Parness
– volume: 57
  start-page: 327
  year: 2007
  end-page: 335
  ident: bib55
  article-title: A simple technique for isolating healthy heart cells from mouse models
  publication-title: J. Physiol. Sci.
  contributor:
    fullname: Shioya
– volume: 27
  start-page: 977
  year: 2006
  end-page: 989
  ident: bib8
  article-title: Mutations in RYR1 in malignant hyperthermia and central core disease
  publication-title: Hum. Mutat.
  contributor:
    fullname: Hopkins
– volume: 54
  start-page: 2065
  year: 2009
  end-page: 2074
  ident: bib19
  article-title: The RYR2-encoded ryanodine receptor/calcium release channel in patients diagnosed previously with either catecholaminergic polymorphic ventricular tachycardia or genotype negative, exercise-induced long QT syndrome
  publication-title: J. Am. Coll. Cardiol.
  contributor:
    fullname: Ackerman
– volume: 51
  start-page: 357
  year: 2011
  end-page: 369
  ident: bib30
  article-title: Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels
  publication-title: J. Mol. Cell. Cardiol.
  contributor:
    fullname: van Helden
– volume: 19
  start-page: 1319
  year: 2008
  end-page: 1321
  ident: bib25
  article-title: Sudden death in a young man with catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation
  publication-title: J. Cardiovasc. Electrophysiol.
  contributor:
    fullname: Birnie
– volume: 53
  start-page: 1993
  year: 2009
  end-page: 2005
  ident: bib29
  article-title: Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor
  publication-title: J. Am. Coll. Cardiol.
  contributor:
    fullname: Matsuzak
– volume: 42
  start-page: 291
  year: 2021
  end-page: 304
  ident: bib7
  article-title: Regulatory mechanisms of ryanodine receptor/Ca
  publication-title: J. Muscle Res. Cell Motil.
  contributor:
    fullname: Murayama
– volume: 3
  start-page: 1486
  year: 2006
  end-page: 1489
  ident: bib24
  article-title: Sudden cardiac death despite an implantable cardioverter-defibrillator in a young female with catecholaminergic ventricular tachycardia
  publication-title: Heart Rhythm
  contributor:
    fullname: Krahn
– year: 2023
  ident: bib32
  article-title: Screening of novel RyR2 inhibitors from well-characterized drug library by ER Ca
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: Kurebayashi
– volume: 59
  start-page: 364
  year: 2004
  end-page: 373
  ident: bib10
  article-title: Dantrolene – a review of its pharmacology, therapeutic use and new developments
  publication-title: Anaesthesia
  contributor:
    fullname: Wappler
– volume: 87
  start-page: e71
  year: 2019
  ident: MEDLINE:31834676
  article-title: Assays for Modulators of Ryanodine Receptor (RyR)/Ca2+ Release Channel Activity for Drug Discovery for Skeletal Muscle and Heart Diseases.
  publication-title: Current protocols in pharmacology
  doi: 10.1002/cpph.71
  contributor:
    fullname: Murayama, Takashi
– volume: 40
  start-page: 49
  year: 2015
  ident: WOS:000347862900007
  article-title: How cryo-EM is revolutionizing structural biology
  publication-title: TRENDS IN BIOCHEMICAL SCIENCES
  doi: 10.1016/j.tibs.2014.10.005
  contributor:
    fullname: Bai, XC
– volume: 27
  start-page: 977
  year: 2006
  ident: WOS:000240410300001
  article-title: Mutations in RYR1 in malignant hyperthermia and central core disease
  publication-title: HUMAN MUTATION
  doi: 10.1002/humu.20356
  contributor:
    fullname: Robinson, R
– volume: 82
  start-page: 893
  year: 2002
  ident: WOS:000178146000003
  article-title: Ryanodine receptor calcium release channels
  publication-title: PHYSIOLOGICAL REVIEWS
  doi: 10.1152/physrev.00013.2002
  contributor:
    fullname: Fill, M
– volume: 2
  start-page: ARTN a003996
  year: 2010
  ident: WOS:000283646900004
  article-title: Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release
  publication-title: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
  doi: 10.1101/cshperspect.a003996
  contributor:
    fullname: Lanner, JT
– volume: 69
  start-page: 111
  year: 2021
  ident: WOS:000768195700021
  article-title: Sudden death after inappropriate shocks of implantable cardioverter defibrillator in a catecholaminergic polymorphic ventricular tachycardia case with a novel RyR2 mutation
  publication-title: JOURNAL OF ELECTROCARDIOLOGY
  doi: 10.1016/j.jelectrocard.2021.09.015
  contributor:
    fullname: Itoh, H
– volume: 369
  start-page: 151
  year: 2004
  ident: WOS:000188836400002
  article-title: Comparative pharmacology of human β-adrenergic receptor subtypes -: characterization of stably transfected receptors in CHO cells
  publication-title: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
  doi: 10.1007/s00210-003-0860-y
  contributor:
    fullname: Hoffmann, C
– volume: 452
  start-page: 665
  year: 2014
  ident: WOS:000343023900058
  article-title: A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes
  publication-title: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  doi: 10.1016/j.bbrc.2014.08.132
  contributor:
    fullname: Okudaira, N
– volume: 54
  start-page: 2065
  year: 2009
  ident: WOS:000271902500013
  article-title: The RYR2-Encoded Ryanodine Receptor/Calcium Release Channel in Patients Diagnosed Previously With Either Catecholaminergic Polymorphic Ventricular Tachycardia or Genotype Negative, Exercise-Induced Long QT Syndrome A Comprehensive Open Reading Frame Mutational Analysis
  publication-title: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
  doi: 10.1016/j.jacc.2009.08.022
  contributor:
    fullname: Medeiros-Domingo, A
– volume: 30
  start-page: 1025
  year: 2022
  ident: WOS:000827591300002
  article-title: A drug and ATP binding site in type 1 ryanodine receptor
  publication-title: STRUCTURE
  doi: 10.1016/j.str.2022.04.010
  contributor:
    fullname: Melville, Z
– volume: 69
  start-page: ARTN 102356
  year: 2023
  ident: WOS:000948422800001
  article-title: Drug development for the treatment of RyR1-related skeletal muscle diseases
  publication-title: CURRENT OPINION IN PHARMACOLOGY
  doi: 10.1016/j.coph.2023.102356
  contributor:
    fullname: Murayama, T
– volume: 80
  start-page: 1907
  year: 2016
  ident: WOS:000383804700010
  article-title: Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) Associated With Ryanodine Receptor (RyR2) Gene Mutations - Long-Term Prognosis After Initiation of Medical Treatment
  publication-title: CIRCULATION JOURNAL
  doi: 10.1253/circj.CJ-16-0250
  contributor:
    fullname: Kawata, H
– volume: 387
  start-page: 905
  year: 2005
  ident: WOS:000229135600040
  article-title: Probing a putative dantrolene-binding site on the cardiac ryanodine receptor
  publication-title: BIOCHEMICAL JOURNAL
  doi: 10.1042/BJ20041336
  contributor:
    fullname: Paul-Pletzer, K
– volume: 9
  start-page: ARTN e95615
  year: 2014
  ident: WOS:000335309100146
  article-title: Generation and Characterization of a Mouse Model Harboring the Exon-3 Deletion in the Cardiac Ryanodine Receptor
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0095615
  contributor:
    fullname: Liu, YJ
– volume: 103
  start-page: 538
  year: 2009
  ident: WOS:000269735400013
  article-title: Genetic variation in RYR1 and malignant hyperthermia phenotypes
  publication-title: BRITISH JOURNAL OF ANAESTHESIA
  doi: 10.1093/bja/aep204
  contributor:
    fullname: Carpenter, D
– volume: 106
  start-page: 69
  year: 2002
  ident: WOS:000176820400016
  article-title: Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia
  publication-title: CIRCULATION
  doi: 10.1161/01.CIR.0000020013.73106.D8
  contributor:
    fullname: Priori, SG
– volume: 262
  start-page: 15637
  year: 1987
  ident: WOS:A1987K886800051
  article-title: ISOLATION OF THE RYANODINE RECEPTOR FROM CARDIAC SARCOPLASMIC-RETICULUM AND IDENTITY WITH THE FEET STRUCTURES
  publication-title: JOURNAL OF BIOLOGICAL CHEMISTRY
  contributor:
    fullname: INUI, M
– volume: 59
  start-page: 364
  year: 2004
  ident: WOS:000220257700011
  article-title: Dantrolene - A review of its pharmacology, therapeutic use and new developments
  publication-title: ANAESTHESIA
  contributor:
    fullname: Krause, T
– volume: 179
  start-page: 837
  year: 2019
  ident: WOS:000486133100062
  article-title: Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay
  publication-title: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1016/j.ejmech.2019.06.076
  contributor:
    fullname: Mori, S
– volume: 57
  start-page: 2244
  year: 2011
  ident: WOS:000291006400006
  article-title: Flecainide Therapy Reduces Exercise-Induced Ventricular Arrhythmias in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
  publication-title: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
  doi: 10.1016/j.jacc.2011.01.026
  contributor:
    fullname: van der Werf, C
– volume: 154
  start-page: ARTN e202112869
  year: 2022
  ident: WOS:000868238500001
  article-title: Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2
  publication-title: JOURNAL OF GENERAL PHYSIOLOGY
  doi: 10.1085/jgp.202112869
  contributor:
    fullname: Kurebayashi, N
– volume: 5
  start-page: ARTN 4153
  year: 2014
  ident: WOS:000338838500009
  article-title: Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA
  publication-title: NATURE COMMUNICATIONS
  doi: 10.1038/ncomms5153
  contributor:
    fullname: Suzuki, J
– volume: 18
  start-page: 3823
  year: 2010
  ident: WOS:000278078600024
  article-title: Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY
  doi: 10.1016/j.bmc.2010.04.047
  contributor:
    fullname: Lamoral-Theys, D
– volume: 240
  start-page: 217
  year: 1972
  ident: WOS:A1972O069400035
  article-title: CALCIUM-IONS AND MUSCLE-CONTRACTION
  publication-title: NATURE
  contributor:
    fullname: EBASHI, S
– volume: 114
  start-page: 10649
  year: 1992
  ident: WOS:A1992KD71700078
  article-title: PREFERENCE OF CIS-AMIDE STRUCTURE IN N-ACYL-N-METHYLANILINES
  publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
  contributor:
    fullname: ITAI, A
– volume: 5
  start-page: 748
  year: 2012
  ident: WOS:000313584500023
  article-title: Familial Evaluation in Catecholaminergic Polymorphic Ventricular Tachycardia Disease Penetrance and Expression in Cardiac Ryanodine Receptor Mutation-Carrying Relatives
  publication-title: CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
  doi: 10.1161/CIRCEP.112.970517
  contributor:
    fullname: van der Werf, C
– volume: 424
  start-page: 35
  year: 2003
  ident: WOS:000183912800031
  article-title: Structure of the core domain of human cardiac troponin in the Ca2+-saturated form
  publication-title: NATURE
  doi: 10.1038/nature01780
  contributor:
    fullname: Takeda, S
– volume: 104
  start-page: 275
  year: 2023
  ident: WOS:001109943800004
  article-title: Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+MonitoringS
  publication-title: MOLECULAR PHARMACOLOGY
  doi: 10.1124/molpharm.123.000720
  contributor:
    fullname: Takenaka, M
– volume: 3
  start-page: 1486
  year: 2006
  ident: WOS:000242860800015
  article-title: Sudden cardiac death despite an implantable cardioverter-defibrillator in a young female with catecholaminergic ventricular tachycardia
  publication-title: HEART RHYTHM
  doi: 10.1016/j.hrthm.2006.08.018
  contributor:
    fullname: Mohamed, U
– volume: 94
  start-page: 722
  year: 2018
  ident: WOS:000435118700006
  article-title: Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels
  publication-title: MOLECULAR PHARMACOLOGY
  doi: 10.1124/mol.117.111468
  contributor:
    fullname: Murayama, T
– volume: 19
  start-page: 1319
  year: 2008
  ident: WOS:000261204100023
  article-title: Sudden Death in a Young Man with Catecholaminergic Polymorphic Ventricular Tachycardia and Paroxysmal Atrial Fibrillation
  publication-title: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
  doi: 10.1111/j.1540-8167.2008.01211.x
  contributor:
    fullname: Pizzale, S
– volume: 46
  start-page: 8440
  year: 2007
  ident: WOS:000250990000024
  article-title: 1,3-dipolar cycloaddition: Click chemistry for the synthesis of 5-substituted tetrazoles from organoaluminum azides and nitriles
  publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
  doi: 10.1002/anie.200701045
  contributor:
    fullname: Aureggi, V
– volume: 53
  start-page: 1993
  year: 2009
  ident: WOS:000266236800010
  article-title: Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor
  publication-title: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
  doi: 10.1016/j.jacc.2009.01.065
  contributor:
    fullname: Kobayashi, S
– volume: 82
  start-page: 887
  year: 2017
  ident: WOS:000392569500005
  article-title: Conversion of Arylboronic Acids to Tetrazoles Catalyzed by ONO Pincer-Type Palladium Complex
  publication-title: JOURNAL OF ORGANIC CHEMISTRY
  doi: 10.1021/acs.joc.6b02277
  contributor:
    fullname: Vignesh, A
– volume: 131
  start-page: 2185
  year: 2015
  ident: WOS:000360528400005
  article-title: Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia The Role of Left Cardiac Sympathetic Denervation
  publication-title: CIRCULATION
  doi: 10.1161/CIRCULATIONAHA.115.015731
  contributor:
    fullname: De Ferrari, GM
– volume: 107
  start-page: 1483
  year: 2010
  ident: WOS:000285143000011
  article-title: In the RyR2R4496C Mouse Model of CPVT, β-Adrenergic Stimulation Induces Ca Waves by Increasing SR Ca Content and Not by Decreasing the Threshold for Ca Waves
  publication-title: CIRCULATION RESEARCH
  doi: 10.1161/CIRCRESAHA.110.227744
  contributor:
    fullname: Kashimura, T
– volume: 149
  start-page: 199
  year: 2017
  ident: WOS:000394254300005
  article-title: Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity
  publication-title: JOURNAL OF GENERAL PHYSIOLOGY
  doi: 10.1085/jgp.201611624
  contributor:
    fullname: Uehara, A
– volume: 100
  start-page: 105
  year: 2007
  ident: WOS:000243407300015
  article-title: Increasing ryanodine receptor open probability alone does not produce arrhythmogenic calcium waves - Threshold sarcoplasmic reticulum calcium content is required
  publication-title: CIRCULATION RESEARCH
  doi: 10.1161/01.RES.0000252828.17939.00
  contributor:
    fullname: Venetucci, LA
– volume: 77
  start-page: 2592
  year: 2021
  ident: WOS:000653014000012
  article-title: Precision Medicine in Catecholaminergic Polymorphic Ventricular Tachycardia
  publication-title: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
  doi: 10.1016/j.jacc.2020.12.073
  contributor:
    fullname: Priori, SG
– volume: 42
  start-page: 291
  year: 2021
  ident: WOS:000516063600001
  article-title: Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies
  publication-title: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
  doi: 10.1007/s10974-020-09575-6
  contributor:
    fullname: Ogawa, H
– volume: 272
  start-page: 26332
  year: 1997
  ident: WOS:A1997YB13900039
  article-title: Caffeine and halothane sensitivity of intracellular Ca2+ release is altered by 15 calcium release channel (ryanodine receptor) mutations associated with malignant hyperthermia and/or central core disease
  publication-title: JOURNAL OF BIOLOGICAL CHEMISTRY
  contributor:
    fullname: Tong, JF
– volume: 82
  start-page: 7256
  year: 1985
  ident: WOS:A1985AUF2900022
  article-title: LOCALIZATION OF CA-2+ RELEASE CHANNELS WITH RYANODINE IN JUNCTIONAL TERMINAL CISTERNAE OF SARCOPLASMIC-RETICULUM OF FAST SKELETAL-MUSCLE
  publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
  contributor:
    fullname: FLEISCHER, S
– volume: 51
  start-page: 357
  year: 2011
  ident: WOS:000294315400010
  article-title: Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels
  publication-title: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
  doi: 10.1016/j.yjmcc.2011.05.009
  contributor:
    fullname: Laver, DR
– volume: 57
  start-page: 327
  year: 2007
  ident: WOS:000252934300001
  article-title: A simple technique for isolating healthy heart cells from mouse models
  publication-title: JOURNAL OF PHYSIOLOGICAL SCIENCES
  doi: 10.2170/physiolsci.RP010107
  contributor:
    fullname: Shioya, T
– volume: 65
  start-page: 531
  year: 2020
  ident: WOS:000518733200001
  article-title: Classification and correlation of RYR2 missense variants in individuals with catecholaminergic polymorphic ventricular tachycardia reveals phenotypic relationships
  publication-title: JOURNAL OF HUMAN GENETICS
  doi: 10.1038/s10038-020-0738-6
  contributor:
    fullname: Olubando, D
– volume: 2011
  start-page: 6343
  year: 2011
  ident: WOS:000296319000023
  article-title: Highly Efficient Synthesis of 5-Substituted 1H-Tetrazoles Catalyzed by Cu-Zn Alloy Nanopowder, Conversion into 1,5-and 2,5-Disubstituted Tetrazoles, and Synthesis and NMR Studies of New Tetrazolium Ionic Liquids
  publication-title: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
  doi: 10.1002/ejoc.201100957
  contributor:
    fullname: Aridoss, G
– volume: 13
  start-page: ARTN 2821
  year: 2022
  ident: WOS:000799632400026
  article-title: Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations
  publication-title: NATURE COMMUNICATIONS
  doi: 10.1038/s41467-022-30429-x
  contributor:
    fullname: Kobayashi, T
– volume: 32
  start-page: 2292
  year: 1989
  ident: WOS:A1989AT15000011
  article-title: RETINOBENZOIC ACIDS .4. CONFORMATION OF AROMATIC AMIDES WITH RETINOIDAL ACTIVITY - IMPORTANCE OF TRANS-AMIDE STRUCTURE FOR THE ACTIVITY
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  contributor:
    fullname: KAGECHIKA, H
– volume: 23
  start-page: ARTN e12512
  year: 2018
  ident: WOS:000437669400003
  article-title: Catecholaminergic polymorphic ventricular tachycardia, an update
  publication-title: ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
  doi: 10.1111/anec.12512
  contributor:
    fullname: Pérez-Riera, AR
– volume: 107
  start-page: 377
  year: 2005
  ident: WOS:000231750800007
  article-title: Abnormal ryanodine receptor function in heart failure
  publication-title: PHARMACOLOGY & THERAPEUTICS
  doi: 10.1016/j.pharmthera.2005.04.003
  contributor:
    fullname: Yano, M
– volume: 71
  start-page: 3
  year: 2015
  ident: WOS:000347804100002
  article-title: Crystal structure refinement with SHELXL
  publication-title: ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY
  doi: 10.1107/S2053229614024218
  contributor:
    fullname: Sheldrick, GM
– volume: 128
  start-page: 321
  year: 2021
  ident: WOS:000639316800004
  article-title: RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT
  publication-title: CIRCULATION RESEARCH
  doi: 10.1161/CIRCRESAHA.120.316819
  contributor:
    fullname: Kryshtal, DO
– volume: 21
  start-page: ARTN 5584
  year: 2020
  ident: WOS:000559043000001
  article-title: Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore
  publication-title: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
  doi: 10.3390/ijms21155584
  contributor:
    fullname: Koga, H
– volume: 74
  start-page: ARTN 117027
  year: 2022
  ident: WOS:000918048100006
  article-title: Development of a water-soluble ryanodine receptor 1 inhibitor
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY
  doi: 10.1016/j.bmc.2022.117027
  contributor:
    fullname: Ishida, R
– volume: 40
  start-page: 49
  year: 2015
  ident: 10.1016/j.ejmech.2023.115910_bib33
  article-title: How cryo-EM is revolutionizing structural biology
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2014.10.005
  contributor:
    fullname: chen Bai
– volume: 94
  start-page: 722
  year: 2018
  ident: 10.1016/j.ejmech.2023.115910_bib36
  article-title: Efficient high-throughput screening by endoplasmic reticulum Ca2+ measurement to identify inhibitors of ryanodine receptor Ca2+-release channels
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.117.111468
  contributor:
    fullname: Murayama
– volume: 131
  start-page: 2185
  year: 2015
  ident: 10.1016/j.ejmech.2023.115910_bib22
  article-title: Clinical management of catecholaminergic polymorphic ventricular tachycardia
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.115.015731
  contributor:
    fullname: De Ferrari
– volume: 80
  start-page: 1907
  year: 2016
  ident: 10.1016/j.ejmech.2023.115910_bib18
  article-title: Catecholaminergic polymorphic ventricular tachycardia (CPVT) associated with ryanodine receptor (RyR2) gene mutations
  publication-title: Circ. J.
  doi: 10.1253/circj.CJ-16-0250
  contributor:
    fullname: Kawata
– volume: 240
  start-page: 217
  year: 1972
  ident: 10.1016/j.ejmech.2023.115910_bib1
  article-title: Calcium ions and muscle contraction
  publication-title: Nature
  doi: 10.1038/240217a0
  contributor:
    fullname: Ebashi
– volume: 65
  start-page: 531
  year: 2020
  ident: 10.1016/j.ejmech.2023.115910_bib14
  article-title: Classification and correlation of RYR2 missense variants in individuals with catecholaminergic polymorphic ventricular tachycardia reveals phenotypic relationships
  publication-title: J. Hum. Genet.
  doi: 10.1038/s10038-020-0738-6
  contributor:
    fullname: Olubando
– volume: 42
  start-page: 291
  year: 2021
  ident: 10.1016/j.ejmech.2023.115910_bib7
  article-title: Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies
  publication-title: J. Muscle Res. Cell Motil.
  doi: 10.1007/s10974-020-09575-6
  contributor:
    fullname: Ogawa
– volume: 179
  start-page: 837e848
  year: 2019
  ident: 10.1016/j.ejmech.2023.115910_bib11
  article-title: Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay
  publication-title: Eur. J. Med. Chem.
  doi: 10.1016/j.ejmech.2019.06.076
  contributor:
    fullname: Mori
– volume: 82
  start-page: 7256
  year: 1985
  ident: 10.1016/j.ejmech.2023.115910_bib3
  article-title: Localization of Ca2+ release channels with ryanodine in junctional terminal cisternae of sarcoplasmic reticulum of fast skeletal muscle
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.82.21.7256
  contributor:
    fullname: Fleischer
– volume: 5
  start-page: 748
  year: 2012
  ident: 10.1016/j.ejmech.2023.115910_bib27
  article-title: Familial evaluation in catecholaminergic polymorphic ventricular tachycardia
  publication-title: Circ. Arrhythm. Electrophysiol.
  doi: 10.1161/CIRCEP.112.970517
  contributor:
    fullname: van der Werf
– volume: 69
  start-page: 111
  year: 2021
  ident: 10.1016/j.ejmech.2023.115910_bib26
  article-title: Sudden death after inappropriate shocks of implantable cardioverter defibrillator in a catecholaminergic polymorphic ventricular tachycardia case with a novel RyR2 mutation
  publication-title: J. Electrocardiol.
  doi: 10.1016/j.jelectrocard.2021.09.015
  contributor:
    fullname: Itoh
– volume: 23
  year: 2018
  ident: 10.1016/j.ejmech.2023.115910_bib21
  article-title: Catecholaminergic polymorphic ventricular tachycardia, an update
  publication-title: Ann. Noninvasive Electrocardiol.
  doi: 10.1111/anec.12512
  contributor:
    fullname: Pérez-Riera
– volume: 74
  year: 2022
  ident: 10.1016/j.ejmech.2023.115910_bib12
  article-title: Development of a water-soluble ryanodine receptor 1 inhibitor
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2022.117027
  contributor:
    fullname: Ishida
– volume: 69
  year: 2023
  ident: 10.1016/j.ejmech.2023.115910_bib13
  article-title: Drug development for the treatment of RyR1-related skeletal muscle diseases
  publication-title: Curr. Opin. Pharmacol.
  doi: 10.1016/j.coph.2023.102356
  contributor:
    fullname: Murayama
– volume: 32
  start-page: 2292
  year: 1992
  ident: 10.1016/j.ejmech.2023.115910_bib39
  article-title: Retinobenzoic acids. 4. Conformation of aromatic amides with retinoidal activity. Importance of trans-amide structure for the activity
  publication-title: J. Med. Chem.
  doi: 10.1021/jm00130a011
  contributor:
    fullname: Kagechika
– volume: 27
  start-page: 977
  year: 2006
  ident: 10.1016/j.ejmech.2023.115910_bib8
  article-title: Mutations in RYR1 in malignant hyperthermia and central core disease
  publication-title: Hum. Mutat.
  doi: 10.1002/humu.20356
  contributor:
    fullname: Robinson
– volume: 57
  start-page: 327
  year: 2007
  ident: 10.1016/j.ejmech.2023.115910_bib55
  article-title: A simple technique for isolating healthy heart cells from mouse models
  publication-title: J. Physiol. Sci.
  doi: 10.2170/physiolsci.RP010107
  contributor:
    fullname: Shioya
– volume: 51
  start-page: 357
  year: 2011
  ident: 10.1016/j.ejmech.2023.115910_bib30
  article-title: Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2011.05.009
  contributor:
    fullname: Laver
– volume: 114
  start-page: 10649
  year: 1992
  ident: 10.1016/j.ejmech.2023.115910_bib38
  article-title: Preference for cis-amide structure in N-acyl-N-methylanilines
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja00052a078
  contributor:
    fullname: Itai
– volume: 13
  start-page: 2821
  year: 2022
  ident: 10.1016/j.ejmech.2023.115910_bib34
  article-title: Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-30429-x
  contributor:
    fullname: Kobayashi
– volume: 21
  start-page: 5584
  year: 2020
  ident: 10.1016/j.ejmech.2023.115910_bib40
  article-title: Development of androgen-antagonistic coumarinamides with a unique aromatic folded pharmacophore
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms21155584
  contributor:
    fullname: Koga
– volume: 5
  start-page: 4153
  year: 2014
  ident: 10.1016/j.ejmech.2023.115910_bib52
  article-title: Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms5153
  contributor:
    fullname: Suzuki
– volume: 30
  start-page: 1025
  year: 2022
  ident: 10.1016/j.ejmech.2023.115910_bib35
  article-title: A drug and ATP binding site in type 1 ryanodine receptor
  publication-title: Structure
  doi: 10.1016/j.str.2022.04.010
  contributor:
    fullname: Melville
– year: 2023
  ident: 10.1016/j.ejmech.2023.115910_bib32
  article-title: Screening of novel RyR2 inhibitors from well-characterized drug library by ER Ca2+ monitoring
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: Takenaka
– volume: 46
  start-page: 8440
  year: 2007
  ident: 10.1016/j.ejmech.2023.115910_bib50
  article-title: 1,3-Dipolar cycloaddition: click chemistry for the synthesis of 5-substituted tetrazoles from organoaluminum azides and nitriles
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/anie.200701045
  contributor:
    fullname: Aureggi
– volume: 82
  start-page: 887
  year: 2017
  ident: 10.1016/j.ejmech.2023.115910_bib49
  article-title: Conversion of arylboronic acids to tetrazoles catalyzed by ONO pincer-type palladium complex
  publication-title: J. Org. Chem.
  doi: 10.1021/acs.joc.6b02277
  contributor:
    fullname: Vignesh
– volume: 107
  start-page: 1483
  year: 2010
  ident: 10.1016/j.ejmech.2023.115910_bib41
  article-title: In the RyR2R4496C mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.110.227744
  contributor:
    fullname: Kashimura
– volume: 154
  year: 2022
  ident: 10.1016/j.ejmech.2023.115910_bib20
  article-title: Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2
  publication-title: J. Gen. Physiol.
  doi: 10.1085/jgp.202112869
  contributor:
    fullname: Kurebayashi
– volume: 3
  start-page: 1486
  year: 2006
  ident: 10.1016/j.ejmech.2023.115910_bib24
  article-title: Sudden cardiac death despite an implantable cardioverter-defibrillator in a young female with catecholaminergic ventricular tachycardia
  publication-title: Heart Rhythm
  doi: 10.1016/j.hrthm.2006.08.018
  contributor:
    fullname: Mohamed
– volume: 77
  start-page: 2592
  year: 2021
  ident: 10.1016/j.ejmech.2023.115910_bib17
  article-title: Precision medicine in catecholaminergic polymorphic ventricular tachycardia: JACC focus seminar 5/5
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2020.12.073
  contributor:
    fullname: Priori
– volume: 82
  start-page: 893
  year: 2002
  ident: 10.1016/j.ejmech.2023.115910_bib5
  article-title: Ryanodine receptor calcium release channels
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00013.2002
  contributor:
    fullname: Fill
– volume: 103
  start-page: 538
  year: 2009
  ident: 10.1016/j.ejmech.2023.115910_bib9
  article-title: Genetic variation in RYR1 and malignant hyperthermia phenotypes
  publication-title: Br. J. Anaesth.
  doi: 10.1093/bja/aep204
  contributor:
    fullname: Carpenter
– volume: 107
  start-page: 377
  year: 2005
  ident: 10.1016/j.ejmech.2023.115910_bib15
  article-title: Abnormal ryanodine receptor function in heart failure
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2005.04.003
  contributor:
    fullname: Yano
– volume: 19
  start-page: 1319
  year: 2008
  ident: 10.1016/j.ejmech.2023.115910_bib25
  article-title: Sudden death in a young man with catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation
  publication-title: J. Cardiovasc. Electrophysiol.
  doi: 10.1111/j.1540-8167.2008.01211.x
  contributor:
    fullname: Pizzale
– volume: 387
  start-page: 905
  year: 2005
  ident: 10.1016/j.ejmech.2023.115910_bib28
  article-title: Probing a putative dantrolene-binding site on the cardiac ryanodine receptor
  publication-title: Biochem. J.
  doi: 10.1042/BJ20041336
  contributor:
    fullname: Paul-Pletzer
– volume: 87
  start-page: e71
  year: 2019
  ident: 10.1016/j.ejmech.2023.115910_bib54
  article-title: Assays for modulators of ryanodine receptor (RyR)/Ca2+ release channel activity for drug discovery for skeletal muscle and heart diseases
  publication-title: Curr. Protoc. Pharmacol.
  doi: 10.1002/cpph.71
  contributor:
    fullname: Murayama
– volume: 369
  start-page: 151
  year: 2004
  ident: 10.1016/j.ejmech.2023.115910_bib45
  article-title: Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cells
  publication-title: Naunyn-Schmiedeberg’s Arch. Pharmacol.
  doi: 10.1007/s00210-003-0860-y
  contributor:
    fullname: Hoffmann
– volume: 452
  start-page: 665
  year: 2014
  ident: 10.1016/j.ejmech.2023.115910_bib43
  article-title: A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2014.08.132
  contributor:
    fullname: Okudaira
– volume: 106
  start-page: 69
  year: 2002
  ident: 10.1016/j.ejmech.2023.115910_bib16
  article-title: Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000020013.73106.D8
  contributor:
    fullname: Priori
– volume: 53
  start-page: 1993
  year: 2009
  ident: 10.1016/j.ejmech.2023.115910_bib29
  article-title: Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2009.01.065
  contributor:
    fullname: Kobayashi
– volume: 18
  start-page: 3823
  year: 2010
  ident: 10.1016/j.ejmech.2023.115910_bib51
  article-title: Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2010.04.047
  contributor:
    fullname: Lamoral-Theys
– volume: 54
  start-page: 2065
  year: 2009
  ident: 10.1016/j.ejmech.2023.115910_bib19
  article-title: The RYR2-encoded ryanodine receptor/calcium release channel in patients diagnosed previously with either catecholaminergic polymorphic ventricular tachycardia or genotype negative, exercise-induced long QT syndrome
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2009.08.022
  contributor:
    fullname: Medeiros-Domingo
– volume: 1228
  start-page: 321
  year: 2021
  ident: 10.1016/j.ejmech.2023.115910_bib31
  article-title: RYR2 channel inhibition is the principal mechanism of flecainide action in CPVT
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.120.316819
  contributor:
    fullname: Kryshtal
– volume: 71
  start-page: 3
  year: 2015
  ident: 10.1016/j.ejmech.2023.115910_bib46
  article-title: SHELXT - integrated space-group and crystal-structure determination
  publication-title: Acta Crystallogr., Sect. A: Found. Adv.
  doi: 10.1107/S2053273314026370
  contributor:
    fullname: Sheldrick
– volume: 424
  start-page: 35
  year: 2003
  ident: 10.1016/j.ejmech.2023.115910_bib2
  article-title: Structure of the core domain of human cardiac troponin in the Ca2+-saturated form
  publication-title: Nature
  doi: 10.1038/nature01780
  contributor:
    fullname: Takeda
– volume: 262
  start-page: 15637
  year: 1987
  ident: 10.1016/j.ejmech.2023.115910_bib4
  article-title: Isolation of the ryanodine receptor from cardiac sarcoplasmic reticulum and identity with the feet structures
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)47774-5
  contributor:
    fullname: Inui
– volume: 57
  start-page: 2244
  year: 2011
  ident: 10.1016/j.ejmech.2023.115910_bib23
  article-title: Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2011.01.026
  contributor:
    fullname: van der Werf
– volume: 71
  start-page: 3
  year: 2015
  ident: 10.1016/j.ejmech.2023.115910_bib47
  article-title: Crystal structure refinement with SHELXL
  publication-title: Acta Crystallogr., Sect. C: Struct. Chem.
  doi: 10.1107/S2053229614024218
  contributor:
    fullname: Sheldrick
– volume: 2
  year: 2010
  ident: 10.1016/j.ejmech.2023.115910_bib6
  article-title: Ryanodine receptors: structure, expression, molecular details, and function in calcium release
  publication-title: Cold Spring Harbor Perspect. Biol.
  doi: 10.1101/cshperspect.a003996
  contributor:
    fullname: Lanner
– volume: 100
  start-page: 105
  year: 2007
  ident: 10.1016/j.ejmech.2023.115910_bib44
  article-title: Increasing ryanodine receptor open probability alone does not produce arrhythmogenic calcium waves
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000252828.17939.00
  contributor:
    fullname: Venetucci
– volume: 9
  year: 2014
  ident: 10.1016/j.ejmech.2023.115910_bib42
  article-title: Generation and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor
  publication-title: PLoS One
  contributor:
    fullname: Liu
– volume: 272
  start-page: 26332
  year: 1997
  ident: 10.1016/j.ejmech.2023.115910_bib53
  article-title: Caffeine and halothane sensitivity of intracellular Ca2+ release is altered by 15 calcium release channel (ryanodine receptor) mutations associated with malignant hyperthermia and/or central core disease
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.272.42.26332
  contributor:
    fullname: Tong
– volume: 59
  start-page: 364
  year: 2004
  ident: 10.1016/j.ejmech.2023.115910_bib10
  article-title: Dantrolene – a review of its pharmacology, therapeutic use and new developments
  publication-title: Anaesthesia
  doi: 10.1111/j.1365-2044.2004.03658.x
  contributor:
    fullname: Krause
– volume: 149
  start-page: 199
  year: 2018
  ident: 10.1016/j.ejmech.2023.115910_bib37
  article-title: Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity
  publication-title: J. Gen. Physiol.
  doi: 10.1085/jgp.201611624
  contributor:
    fullname: Uehara
– start-page: 6343
  year: 2011
  ident: 10.1016/j.ejmech.2023.115910_bib48
  article-title: Highly efficient synthesis of 5-substituted 1H-tetrazoles catalyzed by Cu-Zn alloy nanopowder, conversion into 1,5- and 2,5-disubstituted tetrazoles, and synthesis and NMR studies of new tetrazolium ionic liquids
  publication-title: Eur. J. Org. Chem.
  doi: 10.1002/ejoc.201100957
  contributor:
    fullname: Aridoss
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Snippet Ryanodine receptor 2 (RyR2) is a Ca2+ release channel mainly located on the sarcoplasmic reticulum (SR) membrane of heart muscle cells and regulates the...
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SubjectTerms Arrhythmias drug candidate
Ca2+ channel inhibitor
Chemistry, Medicinal
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Ryanodine receptor 2
Science & Technology
Structure-activity relationship
Title A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment
URI https://dx.doi.org/10.1016/j.ejmech.2023.115910
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