Antiviral and anti-inflammatory drugs to combat COVID-19: Effects on cardiac ion channels and risk of ventricular arrhythmias

• Published in: BioImpacts : BI Vol. 12; no. 1; pp. 9 - 20
• Main Authors: Cubeddu, Luigi X, de la Rosa, Daisy, Ameruoso, Michele
• Format: Journal Article
• Language: English
• Published: Iran Tabriz University of Medical Sciences 01.01.2022; Tabriz University of Medical Sciences (TUOMS Publishing Group)
• Subjects: Antagonists; Antibiotics; Antiviral activity; Antiviral agents; Arrhythmia; Autoimmune diseases; Azithromycin; Chloroquine; Coronaviruses; COVID-19; cytokines; Dexamethasone; Doxycycline; drugs and covid-19; Heart; herg potassium channels; Hydroxychloroquine; Immunosuppressive agents; Interleukin 1; Interleukin 1 receptor antagonist; Interleukin 6; Ion channels; Janus kinase; Janus kinase 2; Kinases; long qt; Lopinavir; Monoclonal antibodies; Mutation; Pandemics; Patients; Protein-tyrosine kinase; Review; Steroid hormones; torsade de pointes; tyrosine kinase inhibitors; Ventricle; Drugs and COVID-19; Cytokines; Torsade de Pointes; hERG potassium channels; Tyrosine kinase inhibitors; Long QT

Drugs with no indication for the treatment of cardiovascular diseases (e.g., drugs employed to treat COVID-19) can increase the risk of arrhythmias. Of interest, a six-fold increase in the number of arrhythmic events was reported in patients with severe COVID-19. In this study, we reviewed (i) the p...