Late-onset disease is associated with a mild phenotype in children with familial Mediterranean fever

Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterised by recurrent, self-limited attacks of fever with serositis. Recently, it was shown that patients with early disease onset during childhood period had more severe disease. The aim of this study was to describe the dem...

Full description

Saved in:
Bibliographic Details
Published inClinical rheumatology Vol. 35; no. 7; pp. 1837 - 1840
Main Authors Özdel, Semanur, Özçakar, Z.Birsin, Kunt, Seda Şahin, Elhan, Atilla H., Yalçınkaya, Fatoş
Format Journal Article
LanguageEnglish
Published London Springer London 01.07.2016
Springer Nature B.V
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterised by recurrent, self-limited attacks of fever with serositis. Recently, it was shown that patients with early disease onset during childhood period had more severe disease. The aim of this study was to describe the demographic, clinical and genetic features of FMF patients who had late-onset disease during childhood period and to compare them to those with earlier onset patients. Files of patients who had been seen in our department between January 2013 and January 2014 were retrospectively evaluated. Patients were divided into two groups according to age of disease onset (group I, ≤8 years; group II, >8 years), and clinical findings were compared between the two groups. The study group comprised 317 FMF patients. There were 267 patients in group I and 50 patients in Group II. Median attack frequency was 24/year in group I and 12/year in group II ( p  < 0.05). Fever and M694V homozygosity were less frequently detected in group II ( p  = 0.003 and p  = 0.022). Median delay in diagnosis was 24 months in group I and 12 months in group II ( p  = 0.002). Disease severity scores and final colchicine dosages were lower in group II ( p  < 0.001 and p  = 0.003). Only a small number of FMF patients had disease onset at older ages in childhood period. It seems that FMF patients with late-onset disease have milder illness. However, more readily expression of their clinical findings in older ages yields earlier diagnosis in this group.
AbstractList Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterised by recurrent, self-limited attacks of fever with serositis. Recently, it was shown that patients with early disease onset during childhood period had more severe disease. The aim of this study was to describe the demographic, clinical and genetic features of FMF patients who had late-onset disease during childhood period and to compare them to those with earlier onset patients. Files of patients who had been seen in our department between January 2013 and January 2014 were retrospectively evaluated. Patients were divided into two groups according to age of disease onset (group I, [less than or equal to]8 years; group II, >8 years), and clinical findings were compared between the two groups. The study group comprised 317 FMF patients. There were 267 patients in group I and 50 patients in Group II. Median attack frequency was 24/year in group I and 12/year in group II (p<0.05). Fever and M694V homozygosity were less frequently detected in group II (p=0.003 and p=0.022). Median delay in diagnosis was 24 months in group I and 12 months in group II (p=0.002). Disease severity scores and final colchicine dosages were lower in group II (p<0.001 and p=0.003). Only a small number of FMF patients had disease onset at older ages in childhood period. It seems that FMF patients with late-onset disease have milder illness. However, more readily expression of their clinical findings in older ages yields earlier diagnosis in this group.
Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterised by recurrent, self-limited attacks of fever with serositis. Recently, it was shown that patients with early disease onset during childhood period had more severe disease. The aim of this study was to describe the demographic, clinical and genetic features of FMF patients who had late-onset disease during childhood period and to compare them to those with earlier onset patients. Files of patients who had been seen in our department between January 2013 and January 2014 were retrospectively evaluated. Patients were divided into two groups according to age of disease onset (group I, ≤8 years; group II, &gt;8 years), and clinical findings were compared between the two groups. The study group comprised 317 FMF patients. There were 267 patients in group I and 50 patients in Group II. Median attack frequency was 24/year in group I and 12/year in group II (p &lt; 0.05). Fever and M694V homozygosity were less frequently detected in group II (p = 0.003 and p = 0.022). Median delay in diagnosis was 24 months in group I and 12 months in group II (p = 0.002). Disease severity scores and final colchicine dosages were lower in group II (p &lt; 0.001 and p = 0.003). Only a small number of FMF patients had disease onset at older ages in childhood period. It seems that FMF patients with late-onset disease have milder illness. However, more readily expression of their clinical findings in older ages yields earlier diagnosis in this group.
Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterised by recurrent, self-limited attacks of fever with serositis. Recently, it was shown that patients with early disease onset during childhood period had more severe disease. The aim of this study was to describe the demographic, clinical and genetic features of FMF patients who had late-onset disease during childhood period and to compare them to those with earlier onset patients. Files of patients who had been seen in our department between January 2013 and January 2014 were retrospectively evaluated. Patients were divided into two groups according to age of disease onset (group I, ≤8 years; group II, >8 years), and clinical findings were compared between the two groups. The study group comprised 317 FMF patients. There were 267 patients in group I and 50 patients in Group II. Median attack frequency was 24/year in group I and 12/year in group II (p < 0.05). Fever and M694V homozygosity were less frequently detected in group II (p = 0.003 and p = 0.022). Median delay in diagnosis was 24 months in group I and 12 months in group II (p = 0.002). Disease severity scores and final colchicine dosages were lower in group II (p < 0.001 and p = 0.003). Only a small number of FMF patients had disease onset at older ages in childhood period. It seems that FMF patients with late-onset disease have milder illness. However, more readily expression of their clinical findings in older ages yields earlier diagnosis in this group.
Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterised by recurrent, self-limited attacks of fever with serositis. Recently, it was shown that patients with early disease onset during childhood period had more severe disease. The aim of this study was to describe the demographic, clinical and genetic features of FMF patients who had late-onset disease during childhood period and to compare them to those with earlier onset patients. Files of patients who had been seen in our department between January 2013 and January 2014 were retrospectively evaluated. Patients were divided into two groups according to age of disease onset (group I, ≤8 years; group II, >8 years), and clinical findings were compared between the two groups. The study group comprised 317 FMF patients. There were 267 patients in group I and 50 patients in Group II. Median attack frequency was 24/year in group I and 12/year in group II ( p  < 0.05). Fever and M694V homozygosity were less frequently detected in group II ( p  = 0.003 and p  = 0.022). Median delay in diagnosis was 24 months in group I and 12 months in group II ( p  = 0.002). Disease severity scores and final colchicine dosages were lower in group II ( p  < 0.001 and p  = 0.003). Only a small number of FMF patients had disease onset at older ages in childhood period. It seems that FMF patients with late-onset disease have milder illness. However, more readily expression of their clinical findings in older ages yields earlier diagnosis in this group.
Author Yalçınkaya, Fatoş
Kunt, Seda Şahin
Elhan, Atilla H.
Özçakar, Z.Birsin
Özdel, Semanur
Author_xml – sequence: 1
  givenname: Semanur
  surname: Özdel
  fullname: Özdel, Semanur
  organization: Department of Pediatrics, Division of Pediatric Rheumatology, Ankara University School of Medicine
– sequence: 2
  givenname: Z.Birsin
  surname: Özçakar
  fullname: Özçakar, Z.Birsin
  organization: Department of Pediatrics, Division of Pediatric Rheumatology, Ankara University School of Medicine
– sequence: 3
  givenname: Seda Şahin
  surname: Kunt
  fullname: Kunt, Seda Şahin
  organization: Department of Pediatrics, Division of Pediatric Rheumatology, Ankara University School of Medicine
– sequence: 4
  givenname: Atilla H.
  surname: Elhan
  fullname: Elhan, Atilla H.
  organization: Department of Biostatistics, Ankara University School of Medicine
– sequence: 5
  givenname: Fatoş
  surname: Yalçınkaya
  fullname: Yalçınkaya, Fatoş
  email: fyalcin@medicine.ankara.edu.tr
  organization: Department of Pediatrics, Division of Pediatric Rheumatology, Ankara University School of Medicine, Ankara Üniversitesi Tıp Fakültesi
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26842301$$D View this record in MEDLINE/PubMed
BookMark eNqFkU-PFCEQxYnZjTu7-gG8GBIvXtqtoukGjmaz_klmsxc9EwaqHTY99Ag9mvn2MvZqjInxAoH3q0cV75KdpSkRYy8Q3iCAui517VUD2Dctmr45PmErlK1sjJHmjK1AKTgp-oJdlvIAAEIbfMouRK-laAFXLKzdTM2UCs08xEKuEI-Fu1ImH6sU-Pc4b7njuzgGvt9SmubjvjKJ-229ypQWYnCViG7kdxTiTDm7RC7xgb5RfsbOBzcWev64X7HP724_3Xxo1vfvP968XTdeQjc3nQrYu8FoMYRe-G4TtOt6jURCQT26XmyMCBhkG7DTrfMd6CG0XnZAnaf2ir1efPd5-nqgMttdLJ7GsfYyHYpFDVoJqdD8H1VG11-U7Ql99Rf6MB1yqoP8pASgEVgpXCifp1IyDXaf487lo0Wwp7TskpatadlTWvZYa14-Oh82Owq_K37FUwGxAKVK6QvlP57-p-sP1H2hzw
CitedBy_id crossref_primary_10_1007_s00431_023_05061_6
crossref_primary_10_1016_j_pedneo_2022_06_014
crossref_primary_10_3389_fped_2021_805919
crossref_primary_10_1007_s10067_023_06802_6
crossref_primary_10_1097_RHU_0000000000001134
crossref_primary_10_1007_s10067_019_04765_1
crossref_primary_10_1007_s10067_016_3275_0
crossref_primary_10_7759_cureus_54170
crossref_primary_10_1007_s00296_018_04236_x
crossref_primary_10_1155_2020_6649525
crossref_primary_10_1111_cge_13223
crossref_primary_10_1080_14397595_2021_1908502
crossref_primary_10_3389_fimmu_2024_1397890
crossref_primary_10_1093_mr_roab054
crossref_primary_10_1111_ped_15017
crossref_primary_10_1097_RHU_0000000000001637
crossref_primary_10_1080_14397595_2018_1500874
crossref_primary_10_32708_uutfd_1410535
crossref_primary_10_34087_cbusbed_696594
crossref_primary_10_1080_14397595_2019_1621440
crossref_primary_10_1080_14397595_2020_1719594
crossref_primary_10_1111_bcp_15149
crossref_primary_10_3390_children9111654
crossref_primary_10_1111_ijcp_14678
crossref_primary_10_1007_s00393_020_00886_0
crossref_primary_10_1186_s12969_023_00875_y
crossref_primary_10_1007_s10067_016_3233_x
Cites_doi 10.1093/rheumatology/ken509
10.1016/j.jpeds.2009.12.010
10.1016/S0140-6736(97)09408-7
10.1002/(SICI)1096-8628(19991105)87:1<30::AID-AJMG6>3.0.CO;2-B
10.1002/(SICI)1096-8628(19980113)75:2<216::AID-AJMG20>3.0.CO;2-R
10.3899/jrheum.090687
10.1016/0002-9343(67)90167-2
10.1038/sj.ejhg.5200674
10.1093/rheumatology/keu138
10.1093/qjmed/92.6.309
10.1086/302327
10.1016/j.autrev.2012.07.025
10.1053/berh.2000.0089
10.1097/01.md.0000152370.84628.0c
10.1111/j.1742-1241.2004.00294.x
10.1016/j.autrev.2015.08.008
ContentType Journal Article
Copyright International League of Associations for Rheumatology (ILAR) 2016
Copyright_xml – notice: International League of Associations for Rheumatology (ILAR) 2016
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7T5
7X7
7XB
88E
8AO
8FI
8FJ
8FK
ABUWG
AFKRA
BENPR
CCPQU
FYUFA
GHDGH
H94
K9.
M0S
M1P
PQEST
PQQKQ
PQUKI
7X8
DOI 10.1007/s10067-016-3196-y
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Immunology Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central
ProQuest One Community College
Health Research Premium Collection
Health Research Premium Collection (Alumni)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
Medical Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Pharma Collection
ProQuest Hospital Collection (Alumni)
ProQuest Central
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest Medical Library
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
AIDS and Cancer Research Abstracts
Immunology Abstracts
ProQuest One Academic
ProQuest Medical Library (Alumni)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList ProQuest One Academic Eastern Edition
MEDLINE - Academic
MEDLINE

AIDS and Cancer Research Abstracts
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: 7X7
  name: Health & Medical Collection (Proquest)
  url: https://search.proquest.com/healthcomplete
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1434-9949
EndPage 1840
ExternalDocumentID 4095009481
10_1007_s10067_016_3196_y
26842301
Genre Journal Article
GroupedDBID ---
-53
-5E
-5G
-BR
-EM
-Y2
-~C
.86
.VR
06C
06D
0R~
0VY
199
1N0
1SB
203
28-
29B
29~
2J2
2JN
2JY
2KG
2KM
2LR
2P1
2VQ
2~H
30V
36B
3V.
4.4
406
408
409
40D
40E
53G
5GY
5QI
5RE
5VS
67Z
6NX
78A
7X7
88E
8AO
8FI
8FJ
8TC
8UJ
95-
95.
95~
96X
AAAVM
AABHQ
AABYN
AAFGU
AAHNG
AAIAL
AAJKR
AAKSU
AANXM
AANZL
AAPBV
AARHV
AARTL
AATNV
AATVU
AAUYE
AAWCG
AAYFA
AAYIU
AAYQN
AAYTO
ABBBX
ABBXA
ABDZT
ABECU
ABFGW
ABFTV
ABHLI
ABHQN
ABIPD
ABJNI
ABJOX
ABKAS
ABKCH
ABKTR
ABMNI
ABMQK
ABNWP
ABPLI
ABPTK
ABQBU
ABSXP
ABTEG
ABTKH
ABTMW
ABULA
ABUWG
ABWNU
ABXPI
ACBMV
ACBRV
ACBXY
ACBYP
ACGFS
ACHSB
ACHXU
ACIGE
ACIPQ
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACPRK
ACTTH
ACUDM
ACVWB
ACWMK
ADBBV
ADHHG
ADHIR
ADIMF
ADINQ
ADJJI
ADKNI
ADKPE
ADMDM
ADOXG
ADRFC
ADTPH
ADURQ
ADYFF
ADZKW
AEBTG
AEEQQ
AEFIE
AEFTE
AEGAL
AEGNC
AEJHL
AEJRE
AEKMD
AENEX
AEOHA
AEPYU
AESKC
AESTI
AETLH
AEVLU
AEVTX
AEXYK
AFAFS
AFEXP
AFKRA
AFLOW
AFNRJ
AFQWF
AFWTZ
AFZKB
AGAYW
AGDGC
AGGBP
AGGDS
AGJBK
AGKHE
AGMZJ
AGQMX
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHIZS
AHKAY
AHMBA
AHSBF
AHVUH
AHYZX
AIAKS
AIIXL
AILAN
AIMYW
AITGF
AJBLW
AJDOV
AJRNO
AJZVZ
AKMHD
AKQUC
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMKLP
AMXSW
AMYLF
AMYQR
AOCGG
ARMRJ
ASPBG
AVWKF
AXYYD
AZFZN
B-.
BA0
BBWZM
BDATZ
BENPR
BGNMA
BPHCQ
BVXVI
CAG
CCPQU
COF
CS3
CSCUP
DDRTE
DL5
DNIVK
DPUIP
DU5
EBD
EBLON
EBS
EIOEI
EJD
EMB
EMOBN
EN4
ESBYG
F5P
FEDTE
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FWDCC
FYUFA
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GNWQR
GQ6
GQ7
GQ8
GRRUI
GXS
HF~
HG5
HG6
HMCUK
HMJXF
HQYDN
HRMNR
HVGLF
HZ~
I09
IHE
IJ-
IKXTQ
IMOTQ
ITM
IWAJR
IXC
IZIGR
IZQ
I~X
I~Z
J-C
J0Z
JBSCW
JCJTX
JZLTJ
KDC
KOV
KOW
KPH
LAS
LLZTM
M1P
M4Y
MA-
N2Q
N9A
NB0
NDZJH
NPVJJ
NQJWS
NU0
O9-
O93
O9G
O9I
O9J
OAM
P19
P2P
P9S
PF0
PQQKQ
PROAC
PSQYO
PT4
PT5
Q2X
QOK
QOR
QOS
R4E
R89
R9I
RHV
RIG
RNI
RNS
ROL
RPX
RRX
RSV
RZK
S16
S1Z
S26
S27
S28
S37
S3B
SAP
SCLPG
SDE
SDH
SDM
SHX
SISQX
SJYHP
SMD
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
SV3
SZ9
SZN
T13
T16
TSG
TSK
TSV
TT1
TUC
U2A
U9L
UG4
UKHRP
UNUBA
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W23
W48
WJK
WK8
YLTOR
Z45
Z5O
Z7U
Z7V
Z7X
Z81
Z82
Z83
Z87
Z8O
Z8V
Z91
ZGI
ZMTXR
ZOVNA
~A9
~EX
~KM
AACDK
AAEOY
AAJBT
AASML
AAYZH
ABAKF
ACAOD
ACDTI
ACZOJ
AEFQL
AEMSY
AFBBN
AGQEE
AGRTI
AIGIU
AJOOF
ALIPV
CGR
CUY
CVF
ECM
EIF
H13
NPM
AAYXX
CITATION
7T5
7XB
8FK
H94
K9.
PQEST
PQUKI
7X8
ID FETCH-LOGICAL-c405t-57d16af982fd62c5bd8a5681ee270c5ba62b92d1d43d1583ac508fd3c450e5ce3
IEDL.DBID 7X7
ISSN 0770-3198
IngestDate Wed Dec 04 03:45:06 EST 2024
Wed Dec 04 09:44:53 EST 2024
Thu Oct 10 22:07:24 EDT 2024
Fri Nov 22 01:13:14 EST 2024
Tue Oct 15 23:50:42 EDT 2024
Sat Dec 16 12:02:52 EST 2023
IsPeerReviewed true
IsScholarly true
Issue 7
Keywords Disease severity
Paediatric
Familial Mediterranean fever
Late onset
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c405t-57d16af982fd62c5bd8a5681ee270c5ba62b92d1d43d1583ac508fd3c450e5ce3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 26842301
PQID 1798201921
PQPubID 326351
PageCount 4
ParticipantIDs proquest_miscellaneous_1808724719
proquest_miscellaneous_1798994439
proquest_journals_1798201921
crossref_primary_10_1007_s10067_016_3196_y
pubmed_primary_26842301
springer_journals_10_1007_s10067_016_3196_y
PublicationCentury 2000
PublicationDate 2016-07-01
PublicationDateYYYYMMDD 2016-07-01
PublicationDate_xml – month: 07
  year: 2016
  text: 2016-07-01
  day: 01
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: Germany
– name: Heidelberg
PublicationSubtitle Journal of the International League of Associations for Rheumatology
PublicationTitle Clinical rheumatology
PublicationTitleAbbrev Clin Rheumatol
PublicationTitleAlternate Clin Rheumatol
PublicationYear 2016
Publisher Springer London
Springer Nature B.V
Publisher_xml – name: Springer London
– name: Springer Nature B.V
References Padeh, Livneh, Pras (CR8) 2010; 156
Tamir, Langevitz, Zemer (CR9) 1999; 87
Padeh, Livneh, Pras (CR14) 2010; 37
Yilmaz, Ozen, Balci (CR4) 2001; 9
Yalcinkaya, Ozcakar, Tanyildiz (CR7) 2011; 29
Tunca, Akar, Onen (CR13) 2005; 84
Ben-Chetrit, Levy (CR3) 1998; 28
Aksentijevich, Torosyan, Samuels (CR5) 1999; 64
Nobakht, Zamani, Ajdarkosh (CR16) 2011; 3
Lidar, Yonath, Shechter (CR18) 2012; 12
Pras, Livneh, Balow (CR11) 1998; 13
Livneh, Langevitz (CR1) 2000; 14
Ozcakar, Elhan, Yalçınkaya (CR12) 2014; 53
Yalcinkaya, Ozen, Ozcakar (CR10) 2009; 48
Sayarlioglu, Cefle, Inanc (CR15) 2005; 59
Majeed, Rawashdeh, el-Shanti (CR6) 1999; 92
Hernández-Rodríguez, Ruíz-Ortiz, Tomé (CR17) 2016; 15
Sohar, Gafni, Pras (CR2) 1967; 43
21813071 - Clin Exp Rheumatol. 2011 Jul-Aug;29(4 Suppl 67):S87-90
27005935 - Clin Rheumatol. 2016 Sep;35(9):2377
10090880 - Am J Hum Genet. 1999 Apr;64(4):949-62
22884555 - Autoimmun Rev. 2012 Nov;12 (1):72-6
24764265 - Rheumatology (Oxford). 2014 Oct;53(10 ):1767-72
5340644 - Am J Med. 1967 Aug;43(2):227-53
11464248 - Eur J Hum Genet. 2001 Jul;9(7):553-5
10528243 - Am J Med Genet. 1999 Nov 5;87(1):30-5
25197532 - Middle East J Dig Dis. 2011 Mar;3(1):50-5
20194447 - J Rheumatol. 2010 Apr;37(4):865-9
9450890 - Am J Med Genet. 1998 Jan 13;75(2):216-9
26299986 - Autoimmun Rev. 2016 Jan;15(1):9-15
10985982 - Baillieres Best Pract Res Clin Rheumatol. 2000 Sep;14(3):477-98
20227729 - J Pediatr. 2010 Jun;156(6):985-9
9500348 - Lancet. 1998 Feb 28;351(9103):659-64
19193696 - Rheumatology (Oxford). 2009 Apr;48(4):395-8
15643295 - Medicine (Baltimore). 2005 Jan;84(1):1-11
10616706 - QJM. 1999 Jun;92(6):309-18
15854197 - Int J Clin Pract. 2005 Feb;59(2):202-5
E Pras (3196_CR11) 1998; 13
N Tamir (3196_CR9) 1999; 87
M Lidar (3196_CR18) 2012; 12
F Yalcinkaya (3196_CR10) 2009; 48
I Aksentijevich (3196_CR5) 1999; 64
HA Majeed (3196_CR6) 1999; 92
J Hernández-Rodríguez (3196_CR17) 2016; 15
E Yilmaz (3196_CR4) 2001; 9
E Sohar (3196_CR2) 1967; 43
S Padeh (3196_CR14) 2010; 37
E Ben-Chetrit (3196_CR3) 1998; 28
S Padeh (3196_CR8) 2010; 156
A Livneh (3196_CR1) 2000; 14
ZB Ozcakar (3196_CR12) 2014; 53
H Nobakht (3196_CR16) 2011; 3
M Tunca (3196_CR13) 2005; 84
F Yalcinkaya (3196_CR7) 2011; 29
M Sayarlioglu (3196_CR15) 2005; 59
References_xml – volume: 48
  start-page: 395
  year: 2009
  end-page: 398
  ident: CR10
  article-title: A new set of criteria for the diagnosis of familial Mediterranean fever in childhood
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/ken509
  contributor:
    fullname: Ozcakar
– volume: 156
  start-page: 985
  year: 2010
  end-page: 989
  ident: CR8
  article-title: Familial Mediterranean fever in the first two years of life: a unique phenotype of disease in evolution
  publication-title: J Pediatr
  doi: 10.1016/j.jpeds.2009.12.010
  contributor:
    fullname: Pras
– volume: 28
  start-page: 659
  year: 1998
  end-page: 664
  ident: CR3
  article-title: Familial Mediterranean fever
  publication-title: Lancet
  doi: 10.1016/S0140-6736(97)09408-7
  contributor:
    fullname: Levy
– volume: 29
  start-page: 87
  year: 2011
  end-page: 90
  ident: CR7
  article-title: Familial Mediterranean fever in small children in Turkey
  publication-title: Clin Exp Rheumatol
  contributor:
    fullname: Tanyildiz
– volume: 3
  start-page: 50
  year: 2011
  end-page: 55
  ident: CR16
  article-title: Adult-onset familial Mediterranean fever in Northwestern Iran; clinical feature and treatment outcome
  publication-title: Middle East J Dig Dis
  contributor:
    fullname: Ajdarkosh
– volume: 87
  start-page: 30
  year: 1999
  end-page: 35
  ident: CR9
  article-title: Late-onset familial Mediterranean fever (FMF): a subset with distinct clinical, demographic, and molecular genetic characteristics
  publication-title: Am J Med Genet
  doi: 10.1002/(SICI)1096-8628(19991105)87:1<30::AID-AJMG6>3.0.CO;2-B
  contributor:
    fullname: Zemer
– volume: 13
  start-page: 216
  year: 1998
  end-page: 219
  ident: CR11
  article-title: Clinical differences between North African and Iraqi Jews with familial Mediterranean fever
  publication-title: Am J Med Genet
  doi: 10.1002/(SICI)1096-8628(19980113)75:2<216::AID-AJMG20>3.0.CO;2-R
  contributor:
    fullname: Balow
– volume: 37
  start-page: 865
  year: 2010
  end-page: 869
  ident: CR14
  article-title: Familial Mediterranean fever in children presenting with attacks of fever alone
  publication-title: J Rheumatol
  doi: 10.3899/jrheum.090687
  contributor:
    fullname: Pras
– volume: 43
  start-page: 227
  year: 1967
  end-page: 253
  ident: CR2
  article-title: Familial Mediterranean fever. A survey of 470 cases and review of the literature
  publication-title: Am J Med
  doi: 10.1016/0002-9343(67)90167-2
  contributor:
    fullname: Pras
– volume: 9
  start-page: 553
  year: 2001
  end-page: 555
  ident: CR4
  article-title: Mutation frequency of familial Mediterranean fever and evidence for a high carrier rate in the Turkish population
  publication-title: Eur J Hum Genet
  doi: 10.1038/sj.ejhg.5200674
  contributor:
    fullname: Balci
– volume: 53
  start-page: 1767
  year: 2014
  end-page: 1772
  ident: CR12
  article-title: Can colchicine response be predicted in familial Mediterranean fever patients
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/keu138
  contributor:
    fullname: Yalçınkaya
– volume: 92
  start-page: 309
  year: 1999
  end-page: 318
  ident: CR6
  article-title: Familial Mediterranean fever in children: the expanded clinical profile
  publication-title: QJM
  doi: 10.1093/qjmed/92.6.309
  contributor:
    fullname: el-Shanti
– volume: 64
  start-page: 949
  year: 1999
  end-page: 962
  ident: CR5
  article-title: Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population
  publication-title: Am J Hum Genet
  doi: 10.1086/302327
  contributor:
    fullname: Samuels
– volume: 12
  start-page: 72
  year: 2012
  end-page: 76
  ident: CR18
  article-title: Incomplete response to colchicine in M694V homozygote FMF patients
  publication-title: Autoimmun Rev
  doi: 10.1016/j.autrev.2012.07.025
  contributor:
    fullname: Shechter
– volume: 14
  start-page: 477
  year: 2000
  end-page: 498
  ident: CR1
  article-title: Diagnostic and treatment concerns in familial Mediterranean fever
  publication-title: Baillieres Best Pract Res Clin Rheumatol
  doi: 10.1053/berh.2000.0089
  contributor:
    fullname: Langevitz
– volume: 84
  start-page: 1
  year: 2005
  end-page: 11
  ident: CR13
  article-title: Familial Mediterranean fever (FMF) in Turkey : results of a nationwide multicenter study
  publication-title: Medicine (Baltimore)
  doi: 10.1097/01.md.0000152370.84628.0c
  contributor:
    fullname: Onen
– volume: 59
  start-page: 202
  year: 2005
  end-page: 205
  ident: CR15
  article-title: Characteristics of patients with adult-onset familial Mediterranean fever in Turkey: analysis of 401 cases
  publication-title: Int J Clin Pract
  doi: 10.1111/j.1742-1241.2004.00294.x
  contributor:
    fullname: Inanc
– volume: 15
  start-page: 9
  year: 2016
  end-page: 15
  ident: CR17
  article-title: Clinical and genetic characterization of the autoinflammatory diseases diagnosed in an adult reference center
  publication-title: Autoimmun Rev
  doi: 10.1016/j.autrev.2015.08.008
  contributor:
    fullname: Tomé
– volume: 64
  start-page: 949
  year: 1999
  ident: 3196_CR5
  publication-title: Am J Hum Genet
  doi: 10.1086/302327
  contributor:
    fullname: I Aksentijevich
– volume: 3
  start-page: 50
  year: 2011
  ident: 3196_CR16
  publication-title: Middle East J Dig Dis
  contributor:
    fullname: H Nobakht
– volume: 28
  start-page: 659
  year: 1998
  ident: 3196_CR3
  publication-title: Lancet
  doi: 10.1016/S0140-6736(97)09408-7
  contributor:
    fullname: E Ben-Chetrit
– volume: 43
  start-page: 227
  year: 1967
  ident: 3196_CR2
  publication-title: Am J Med
  doi: 10.1016/0002-9343(67)90167-2
  contributor:
    fullname: E Sohar
– volume: 92
  start-page: 309
  year: 1999
  ident: 3196_CR6
  publication-title: QJM
  doi: 10.1093/qjmed/92.6.309
  contributor:
    fullname: HA Majeed
– volume: 59
  start-page: 202
  year: 2005
  ident: 3196_CR15
  publication-title: Int J Clin Pract
  doi: 10.1111/j.1742-1241.2004.00294.x
  contributor:
    fullname: M Sayarlioglu
– volume: 37
  start-page: 865
  year: 2010
  ident: 3196_CR14
  publication-title: J Rheumatol
  doi: 10.3899/jrheum.090687
  contributor:
    fullname: S Padeh
– volume: 13
  start-page: 216
  year: 1998
  ident: 3196_CR11
  publication-title: Am J Med Genet
  doi: 10.1002/(SICI)1096-8628(19980113)75:2<216::AID-AJMG20>3.0.CO;2-R
  contributor:
    fullname: E Pras
– volume: 9
  start-page: 553
  year: 2001
  ident: 3196_CR4
  publication-title: Eur J Hum Genet
  doi: 10.1038/sj.ejhg.5200674
  contributor:
    fullname: E Yilmaz
– volume: 29
  start-page: 87
  year: 2011
  ident: 3196_CR7
  publication-title: Clin Exp Rheumatol
  contributor:
    fullname: F Yalcinkaya
– volume: 53
  start-page: 1767
  year: 2014
  ident: 3196_CR12
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/keu138
  contributor:
    fullname: ZB Ozcakar
– volume: 14
  start-page: 477
  year: 2000
  ident: 3196_CR1
  publication-title: Baillieres Best Pract Res Clin Rheumatol
  doi: 10.1053/berh.2000.0089
  contributor:
    fullname: A Livneh
– volume: 87
  start-page: 30
  year: 1999
  ident: 3196_CR9
  publication-title: Am J Med Genet
  doi: 10.1002/(SICI)1096-8628(19991105)87:1<30::AID-AJMG6>3.0.CO;2-B
  contributor:
    fullname: N Tamir
– volume: 48
  start-page: 395
  year: 2009
  ident: 3196_CR10
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/ken509
  contributor:
    fullname: F Yalcinkaya
– volume: 156
  start-page: 985
  year: 2010
  ident: 3196_CR8
  publication-title: J Pediatr
  doi: 10.1016/j.jpeds.2009.12.010
  contributor:
    fullname: S Padeh
– volume: 84
  start-page: 1
  year: 2005
  ident: 3196_CR13
  publication-title: Medicine (Baltimore)
  doi: 10.1097/01.md.0000152370.84628.0c
  contributor:
    fullname: M Tunca
– volume: 15
  start-page: 9
  year: 2016
  ident: 3196_CR17
  publication-title: Autoimmun Rev
  doi: 10.1016/j.autrev.2015.08.008
  contributor:
    fullname: J Hernández-Rodríguez
– volume: 12
  start-page: 72
  year: 2012
  ident: 3196_CR18
  publication-title: Autoimmun Rev
  doi: 10.1016/j.autrev.2012.07.025
  contributor:
    fullname: M Lidar
SSID ssj0002891
Score 2.3009508
Snippet Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterised by recurrent, self-limited attacks of fever with serositis. Recently, it...
SourceID proquest
crossref
pubmed
springer
SourceType Aggregation Database
Index Database
Publisher
StartPage 1837
SubjectTerms Adolescent
Child
Colchicine - therapeutic use
Familial Mediterranean Fever - drug therapy
Familial Mediterranean Fever - genetics
Female
Homozygote
Humans
Late Onset Disorders - diagnosis
Male
Medicine
Medicine & Public Health
Mutation
Original Article
Pediatrics
Phenotype
Pyrin - genetics
Retrospective Studies
Rheumatology
Severity of Illness Index
Turkey
SummonAdditionalLinks – databaseName: SpringerLINK - Czech Republic Consortium
  dbid: AGYKE
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1ZS8QwEA4eIL54H-tFBJ-ULG3SI3kU8cDrSUGfSnPBstoVt_ugv96ZHquyKvhSKB3SJDOTmcxMvhBy4AJEfVKWRcI4FkWpYdpLz4TUUiU2VL6qqry5TS7uo8uH-GGK8HHoouh324xktVB_OesGCyvsfBOGUsPepsksmB5Uxtnj88er0_H6y5t78tIUVxgl21zmT418t0YTLuZEerSyOmeL9UnAYQVWiMUm_e6o1F3zPgnl-I8BLZGFxgmlx7XULJMpV6yQuZsmzb5K7DV4oAzrrEvaZHBob0jzhpXOUgzf0pw-954sxSqxAYZyaa-g7eHwmqIKn4CEU2wbOAiG0eUF9Q4UaI3cn53enVyw5joGZsCrK1mc2jDJvZLc24SbWFuZI3yZczwN4DVPuFbchjYSNoylyA04f94KE8WBi40T62SmGBRuk9BACGOsSWEvpSPr4eG5FnGQwx9CpUWHHLZsyV5q1I3sE18Z5y3DyjSct-ytQ3ZaxmWNAg4zxGHj6L6GHbI__gyqg_kQGOtgVNMoFYFL9geNDGTKwYIDzUYtFOMeIVAO7ODgD0cth7904Lfubv2LepvMcxSRqkB4h8yUryO3C25Qqfcauf8AP9L-tw
  priority: 102
  providerName: Springer Nature
Title Late-onset disease is associated with a mild phenotype in children with familial Mediterranean fever
URI https://link.springer.com/article/10.1007/s10067-016-3196-y
https://www.ncbi.nlm.nih.gov/pubmed/26842301
https://www.proquest.com/docview/1798201921
https://search.proquest.com/docview/1798994439
https://search.proquest.com/docview/1808724719
Volume 35
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR3LSsNAcNEK4kV8W62ygidlMdnN8ySttIqPImKhnkKyDyhoWm176N87k2xapeglS9ghmcxMdp47S8i5drDrU6yYJ6RmnhdKlpnIMBFlURwoNzZFVeVTN7jrefd9v28DbmNbVlmticVCrYYSY-RX2FiLoz3iXo8-GZ4ahdlVe4TGKllzOahykOewP3e4MIlWnJgXhrjWxFGV1Sy3zsE6DY50gDMBm_3WS0vG5lKitNA_nS2yaQ1H2iw5vU1WdL5D1p9sanyXqEewGhnWRk-ozbrQwZimlvxaUQy50pR-DN4VxcquIYZf6SCn1YbuEqIIeYBUUnw2UB2UmU5zajQI_R7pddqvN3fMHqHAJFhiE-aHyg1SA6QzKuDSz1SUYssxrXnowG0a8CzmylWeUK4fiVSCwWaUkJ7vaF9qsU9q-TDXh4Q6QkipZAj-T-YpAxfDM-E7KbzBjTNRJxcVAZNR2SkjWfRERmonWE2G1E5mddKoSJzYn2acLFhcJ2fzaRB3zGHAtw6nJUwce2BG_QMTOVHIQesCzEHJvjlG2NwGvC54w2XFzx8I_IXu0f_oHpMNjpJUVPE2SG3yNdUnYKtMstNCIE_JWrPTanVxvH17aMPYanefX2C2x5vfxzPrFA
link.rule.ids 314,780,784,12056,21388,27924,27925,31719,31720,33744,33745,41081,41523,42150,42592,43310,43805,52111,52234,73745,74302
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR3LSsRALOgK6kV8uz5H8KQMtjN9nkRFWXV3EVHwVtp5wIJ21V0P_r1JO10V0UuhNHTSJE0ySSYBODAedX1KNQ-kMjwIYsULm1gukyJJI-2ntqqq7PWjzkNw_Rg-uoDbyJVVNjqxUtR6qChGfkyNtQT5I_7JyyunqVGUXXUjNKZhhjqnhy2YObvo395NdLFwM_PimLRNmjR5zfrwHGpq3EpH9CTiHz8t0y9381eqtLJAl4uw4FxHdlrzegmmTLkMsz2XHF8B3UW_kVN19Ji5vAsbjFjuGGA0o6Ary9nz4Ekzqu0aUgCWDUrWHOmuIaqgB8olo3cj3dGcmbxk1qDYr8LD5cX9eYe7IQpcoS825mGs_Si3SDyrI6HCQic5NR0zRsQe3uaRKFKhfR1I7YeJzBW6bFZLFYSeCZWRa9Aqh6XZAOZJqZRWMe6AikBbvFhRyNDLcQU_LWQbDhsCZi91r4zsqysyUTujejKidvbRhu2GxJn7bUbZF5PbsD95jAJPWQz81uF7DZOmATpS_8AkXhILtLsIs16zb4IRtbfBfReucNTw8xsCf6G7-T-6ezDXue91s-5V_2YL5gVJVVXTuw2t8du72UHPZVzsOvH8BHSm6dc
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR3LSsRALOguiBfx7focwZMy2M70eRIfu_hcRBS8lXYesKBdddeDf2_STldF9FIoEzrTJJNkkkwCsGc8qvqUah5IZXgQxIoXNrFcJkWSRtpPbZVVedOPzh-Cy8fw0eU_jVxaZSMTK0Gth4p85IdUWEuQPeIfWpcWcXvWO3p55dRBiiKtrp3GNLRRK3qiBe2Tbv_2biKXheufF8ckedKkiXHWF-lQauOxOqKRiH_81FK_TM9fYdNKG_XmYc6Zkey4pvsCTJlyEWZuXKB8CfQ12pCcMqXHzMVg2GDEckcMoxk5YFnOngdPmlGe15CcsWxQsuZ6dw1ROUCQRxl9G2mAqs3kJbMGt8AyPPS696fn3DVU4ArtsjEPY-1HuUVEWh0JFRY6yakAmTEi9vA1j0SRCu3rQGo_TGSu0HyzWqog9EyojFyBVjkszRowT0qltIrxNFQE2uLDikKGXo4z-GkhO7DfIDB7qetmZF8VkgnbGeWWEbazjw5sNijO3BYaZV8E78DuZBiZnyIa-K_D9xomTQM0qv6BSbwkFqiDEWa1Jt9kRVTqBs9gOMNBQ89vC_hruev_L3cHZpAzs-uL_tUGzApiqiq9dxNa47d3s4VGzLjYdtz5CWvL7gQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Late-onset+disease+is+associated+with+a+mild+phenotype+in+children+with+familial+Mediterranean+fever&rft.jtitle=Clinical+rheumatology&rft.au=%C3%96zdel%2C+Semanur&rft.au=%C3%96z%C3%A7akar%2C+Zbirsin&rft.au=Kunt%2C+Seda+Sahin&rft.au=Elhan%2C+Atilla+H&rft.date=2016-07-01&rft.pub=Springer+Nature+B.V&rft.issn=0770-3198&rft.eissn=1434-9949&rft.volume=35&rft.issue=7&rft.spage=1837&rft_id=info:doi/10.1007%2Fs10067-016-3196-y&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=4095009481
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0770-3198&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0770-3198&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0770-3198&client=summon