Do Human Atherosclerotic Lesions Contain Nitrotyrosine?
Nitrotyrosine has been widely used as a marker of peroxynitrite formation in normal and diseased tissues. However, studies of normal human aortic intima and atherosclerotic lesions at various stages of development failed to reveal its presence except in a very few specimens of both normal and diseas...
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| Published in | Biochemical and biophysical research communications Vol. 226; no. 2; pp. 346 - 351 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
13.09.1996
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| Abstract | Nitrotyrosine has been widely used as a marker of peroxynitrite formation in normal and diseased tissues. However, studies of normal human aortic intima and atherosclerotic lesions at various stages of development failed to reveal its presence except in a very few specimens of both normal and diseased tissues. The techniques used to detect nitrotyrosine-HPLC with photodiode array detection and Western blotting- were able to identify nitrotyrosine after chemical nitration. Hence peroxynitrite may not be as important in the initiation of atherosclerosis as has commonly been proposed. |
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| AbstractList | Nitrotyrosine has been widely used as a marker of peroxynitrite formation in normal and diseased tissues. However, studies of normal human aortic intima and atherosclerotic lesions at various stages of development failed to reveal its presence except in a very few specimens of both normal and diseased tissues. The techniques used to detect nitrotyrosine-HPLC with photodiode array detection and Western blotting- were able to identify nitrotyrosine after chemical nitration. Hence peroxynitrite may not be as important in the initiation of atherosclerosis as has commonly been proposed. |
| Author | Halliwell, Barry Kaur, Harparkash Evans, Patricia Mitchinson, Malcolm J. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8806638$$D View this record in MEDLINE/PubMed |
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| Copyright | 1996 Academic Press |
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| Snippet | Nitrotyrosine has been widely used as a marker of peroxynitrite formation in normal and diseased tissues. However, studies of normal human aortic intima and... |
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| SubjectTerms | Antibody Specificity Arteriosclerosis - metabolism Blotting, Western Chromatography, High Pressure Liquid Humans Immune Sera Tyrosine - analogs & derivatives Tyrosine - immunology Tyrosine - isolation & purification Tyrosine - metabolism |
| Title | Do Human Atherosclerotic Lesions Contain Nitrotyrosine? |
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