Expression of insulin-like growth factor binding protein-2 (IGFBP-2) gene in negative and positive human cytomegalovirus glioblastoma multiforme tissues

• Published in: Medical oncology (Northwood, London, England) Vol. 31; no. 2; pp. 812 - 6
• Main Authors: Ahani, Narges, Karimi Arzenani, Mohsen, Shirkoohi, Reza, Rokouei, Mohammad, Alipour Eskandani, Majid, Nikravesh, Abbas
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.02.2014; Springer Nature B.V
• Subjects: Adult; Biomarkers, Tumor - genetics; Case-Control Studies; Cytomegalovirus - pathogenicity; Cytomegalovirus Infections - complications; Cytomegalovirus Infections - genetics; Cytomegalovirus Infections - microbiology; Female; Follow-Up Studies; Glioblastoma - genetics; Glioblastoma - microbiology; Glioblastoma - pathology; Hematology; Human cytomegalovirus; Humans; Insulin-Like Growth Factor Binding Protein 2 - genetics; Internal Medicine; Male; Medicine; Medicine & Public Health; Neoplasm Staging; Oncology; Original Paper; Pathology; Prognosis; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Expression; HCMV; Glioblastoma multiforme; IGFBP2

Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults and has but few treatments. The median survival of glioblastoma patients is 12 months. The (possible) relationship between human cytomegalovirus (HCMV) infection and cancer has...