Aberrant DNA methylation of acute myeloid leukemia and colorectal cancer in a Chinese pedigree with a MLL3 germline mutation

• Published in: Tumor biology Vol. 37; no. 9; pp. 12609 - 12618
• Main Authors: Yang, Fuhua, Gong, Qiang, Shi, Wentao, Zou, Yunding, Shi, Jingmin, Wei, Fengjiang, Li, Qingrong, Chen, Jieping, Li, Wei-Dong
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.09.2016; Springer Nature B.V
• Subjects: Adult; Biomedical and Life Sciences; Biomedicine; Cancer Research; Colorectal cancer; Colorectal Neoplasms - genetics; CpG Islands; DNA Methylation; DNA-Binding Proteins - genetics; Germ-Line Mutation; Humans; Leukemia; Leukemia, Myeloid, Acute - genetics; Male; Mutation; Original Article; Pedigree; Tumors; DNA methylation; Acute myeloid leukemia; Colorectal cancer

Unlike genetic aberrations, epigenetic alterations do not modify the deoxyribonucleic acid (DNA) coding sequence and can be reversed pharmacologically. Identifying a particular epigenetic alteration such as abnormal DNA methylation may provide better understanding of cancers and improve current ther...