The significance of a positive second trimester serum screen for trisomy 18

• Published in: The journal of maternal-fetal & neonatal medicine Vol. 23; no. 7; p. 633
• Main Authors: Oyelese, Yinka, Tobon, Luis, Burton, Aiyanna, Adamczak, Joanna, Ashkinadze, Elena, Smulian, John C, Canterino, Joseph
• Format: Journal Article
• Language: English
• Published: England 01.07.2010
• Subjects: Adult; Chromosomes, Human, Pair 18; Congenital Abnormalities - blood; Congenital Abnormalities - diagnosis; Congenital Abnormalities - epidemiology; False Positive Reactions; Female; Humans; Mass Screening - methods; Mass Screening - standards; Mass Screening - statistics & numerical data; Pregnancy; Pregnancy Trimester, Second - blood; Prenatal Diagnosis - methods; Prenatal Diagnosis - standards; Prenatal Diagnosis - statistics & numerical data; Retrospective Studies; Trisomy - diagnosis; Young Adult

We designed this study to estimate the proportion of fetuses in pregnancies with positive second trimester serum screens for trisomy 18 who actually have trisomy 18, to estimate the proportion of women with trisomy 18 who have a negative serum screen, and to assess the role of ultrasound in the diag...