N-glycoprotein macroheterogeneity: biological implications and proteomic characterization

• Published in: Glycoconjugate journal Vol. 33; no. 3; pp. 359 - 376
• Main Authors: Zacchi, Lucia F., Schulz, Benjamin L.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2016; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biomedical and Life Sciences; Glycoproteins; Glycoproteins - chemistry; Glycoproteins - classification; Glycoproteins - metabolism; Glycosylation; Humans; Life Sciences; Mass spectrometry; Mass Spectrometry - methods; Original Article; Pathology; Protein Processing, Post-Translational; Proteome - chemistry; Proteome - classification; Proteome - metabolism; Proteomics; Glycoproteomics; Glycosylation; Macroheterogeneity; Mass spectrometry; Glycoprotein

Glycosylation is a co- and post-translational modification that is critical for the regulation of the biophysical properties and biological activities of diverse proteins. Biosynthetic pathways for protein glycosylation are inherently inefficient, resulting in high structural diversity in mature gly...