Allosteric inhibition of SARS-CoV-2 3CL protease by colloidal bismuth subcitrate

• Published in: Chemical science (Cambridge) Vol. 12; no. 42; pp. 1498 - 1412
• Main Authors: Tao, Xuan, Zhang, Lu, Du, Liubing, Liao, Ruyan, Cai, Huiling, Lu, Kai, Zhao, Zhennan, Xie, Yanxuan, Wang, Pei-Hui, Pan, Ji-An, Zhang, Yuebin, Li, Guohui, Dai, Jun, Mao, Zong-Wan, Xia, Wei
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 03.11.2021; The Royal Society of Chemistry
• Subjects: Bismuth; Chemistry; Chymotrypsin; Cysteine; Dimers; Inhibitors; Protease; Severe acute respiratory syndrome coronavirus 2; Viral diseases

The SARS-CoV-2 3-chymotrypsin-like protease (3CLpro or Mpro) is a key cysteine protease for viral replication and transcription, making it an attractive target for antiviral therapies to combat the COVID-19 disease. Here, we demonstrate that bismuth drug colloidal bismuth subcitrate (CBS) is a poten...