Synaptogenesis: Modulation by Availability of Membrane Phospholipid Precursors

• Published in: Neuromolecular medicine Vol. 18; no. 3; pp. 426 - 440
• Main Author: Cansev, Mehmet
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2016; Springer Nature B.V
• Subjects: Alzheimer Disease - physiopathology; Animals; Biomedical and Life Sciences; Biomedicine; Brain - physiopathology; Dietary Supplements; Docosahexaenoic Acids - metabolism; Internal Medicine; Mice; Neurology; Neurosciences; Original Paper; Phospholipids - metabolism; Rats; Synapses - physiology; Uridine; Cognition; Synaptogenesis; Alzheimer’s disease; Docosahexaenoic acid; Choline

Phospholipids are the main constituents of brain membranes. Formation of new membranes requires that uridine, the omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA), and choline, the three circulating precursors of major phospholipids, interact via the Kennedy pathway. Supplement...