Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System

• Published in: Cold Spring Harbor perspectives in biology Vol. 7; no. 9; p. a020461
• Main Authors: Emery, Ben, Lu, Q. Richard
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.09.2015
• Subjects: Animals; Central Nervous System - metabolism; Chromatin Assembly and Disassembly; DNA Methylation; Epigenesis, Genetic; Humans; Myelin Sheath - metabolism; Oligodendroglia - cytology; PERSPECTIVES; Transcription Factors - metabolism; Transcription, Genetic

Central nervous system (CNS) myelination by oligodendrocytes (OLs) is a highly orchestrated process involving well-defined steps from specification of neural stem cells into proliferative OL precursors followed by terminal differentiation and subsequent maturation of these precursors into myelinatin...