Proteomic identification of aldolase A as an autoantibody target in patients with atypical movement disorders
We tried to identify the target/s of autoantibodies to basal ganglia neurons found in a patient with hyperkinetic movement disorders (HMD) characterized by rapid, rhythmic involuntary movements or spasms in both face and neck. Patient and control sera were used in Western blot to probe mouse brain h...
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Published in | Neurological sciences Vol. 34; no. 3; pp. 313 - 320 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Springer Milan
01.03.2013
Springer Nature B.V |
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Abstract | We tried to identify the target/s of autoantibodies to basal ganglia neurons found in a patient with hyperkinetic movement disorders (HMD) characterized by rapid, rhythmic involuntary movements or spasms in both face and neck. Patient and control sera were used in Western blot to probe mouse brain homogenates. Two-dimensional gel electrophoresis (2-DE) SDS-PAGE protein spots recognized by the patient’s antibodies were excised and sequenced by mass spectrometry analysis, and the glycolytic enzyme aldolase A was identified as the antigen recognized by the patient’s autoantibodies. To assess relevance and specificity of these antibodies to the identified targets as biomarkers of autoimmunity in movement disorders, autoantibody responses to the identified target were then measured by ELISA in various diseases of the central nervous system. Anti-aldolase A autoantibodies were associated mainly with HMD (7/17, 41%) and Parkinson’s disease (4/30, 13%) patients, and undetectable in subjects with other inflammatory and non-inflammatory central nervous system diseases. We, thus, identified aldolase A as an autoantigen in a sub-group of patients with HMD, a clinically ill-defined syndrome. Anti-aldolase A antibodies may represent a useful biomarker of autoimmunity in HMD patients. |
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AbstractList | We tried to identify the target/s of autoantibodies to basal ganglia neurons found in a patient with hyperkinetic movement disorders (HMD) characterized by rapid, rhythmic involuntary movements or spasms in both face and neck. Patient and control sera were used in Western blot to probe mouse brain homogenates. Two-dimensional gel electrophoresis (2-DE) SDS-PAGE protein spots recognized by the patient’s antibodies were excised and sequenced by mass spectrometry analysis, and the glycolytic enzyme aldolase A was identified as the antigen recognized by the patient’s autoantibodies. To assess relevance and specificity of these antibodies to the identified targets as biomarkers of autoimmunity in movement disorders, autoantibody responses to the identified target were then measured by ELISA in various diseases of the central nervous system. Anti-aldolase A autoantibodies were associated mainly with HMD (7/17, 41%) and Parkinson’s disease (4/30, 13%) patients, and undetectable in subjects with other inflammatory and non-inflammatory central nervous system diseases. We, thus, identified aldolase A as an autoantigen in a sub-group of patients with HMD, a clinically ill-defined syndrome. Anti-aldolase A antibodies may represent a useful biomarker of autoimmunity in HMD patients. We tried to identify the target/s of autoantibodies to basal ganglia neurons found in a patient with hyperkinetic movement disorders (HMD) characterized by rapid, rhythmic involuntary movements or spasms in both face and neck. Patient and control sera were used in Western blot to probe mouse brain homogenates. Two-dimensional gel electrophoresis (2-DE) SDS-PAGE protein spots recognized by the patient's antibodies were excised and sequenced by mass spectrometry analysis, and the glycolytic enzyme aldolase A was identified as the antigen recognized by the patient's autoantibodies. To assess relevance and specificity of these antibodies to the identified targets as biomarkers of autoimmunity in movement disorders, autoantibody responses to the identified target were then measured by ELISA in various diseases of the central nervous system. Anti-aldolase A autoantibodies were associated mainly with HMD (7/17, 41%) and Parkinson's disease (4/30, 13%) patients, and undetectable in subjects with other inflammatory and non-inflammatory central nervous system diseases. We, thus, identified aldolase A as an autoantigen in a sub-group of patients with HMD, a clinically ill-defined syndrome. Anti-aldolase A antibodies may represent a useful biomarker of autoimmunity in HMD patients.[PUBLICATION ABSTRACT] Erratum DOI: 10.1007/s10072-012-0996-y |
Author | Furlan, Roberto Alessio, Massimo Franciotta, Diego Fazio, Raffaella Privitera, Daniela Lampasona, Vito Corti, Valeria Volontè, Antonietta Martino, Gianvito Comi, Giancarlo |
Author_xml | – sequence: 1 givenname: Daniela surname: Privitera fullname: Privitera, Daniela organization: Division of Neuroscience, Institute for Experimental Neurology, San Raffaele Scientific Institute – sequence: 2 givenname: Valeria surname: Corti fullname: Corti, Valeria organization: Proteome Biochemistry, San Raffaele Scientific Institute – sequence: 3 givenname: Massimo surname: Alessio fullname: Alessio, Massimo organization: Proteome Biochemistry, San Raffaele Scientific Institute – sequence: 4 givenname: Antonietta surname: Volontè fullname: Volontè, Antonietta organization: Neurology Department, San Raffaele Scientific Institute – sequence: 5 givenname: Vito surname: Lampasona fullname: Lampasona, Vito organization: Genomics for Human Pathologies Diagnostics, Centre for Translational Genomics and Bioinformatics, San Raffaele Scientific Institute – sequence: 6 givenname: Giancarlo surname: Comi fullname: Comi, Giancarlo organization: Division of Neuroscience, Institute for Experimental Neurology, San Raffaele Scientific Institute, Neurology Department, San Raffaele Scientific Institute – sequence: 7 givenname: Gianvito surname: Martino fullname: Martino, Gianvito organization: Division of Neuroscience, Institute for Experimental Neurology, San Raffaele Scientific Institute, Neurology Department, San Raffaele Scientific Institute – sequence: 8 givenname: Diego surname: Franciotta fullname: Franciotta, Diego organization: Neuroimmunology Unit, C. Mondino Neurological Institute – sequence: 9 givenname: Roberto surname: Furlan fullname: Furlan, Roberto email: furlan.roberto@hsr.it organization: Division of Neuroscience, Institute for Experimental Neurology, San Raffaele Scientific Institute, Neurology Department, San Raffaele Scientific Institute – sequence: 10 givenname: Raffaella surname: Fazio fullname: Fazio, Raffaella organization: Division of Neuroscience, Institute for Experimental Neurology, San Raffaele Scientific Institute, Neurology Department, San Raffaele Scientific Institute |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22391679$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_nbd_2023_105997 crossref_primary_10_3389_fimmu_2017_00505 crossref_primary_10_1071_CH22267 crossref_primary_10_1080_13554794_2019_1599025 crossref_primary_10_3389_fmolb_2021_719678 crossref_primary_10_1007_s12020_021_02937_1 crossref_primary_10_1080_14737175_2016_1226133 crossref_primary_10_1016_j_jaut_2021_102644 |
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Keywords | Hyperkinetic movement disorders SERPA Aldolase A |
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SubjectTerms | Aged Autoantibodies Autoantibodies - metabolism Autoantigens Autoimmune diseases Basal ganglia biomarkers Brain Central nervous system Central nervous system diseases Electrophoresis, Gel, Two-Dimensional Enzyme-Linked Immunosorbent Assay Female Fructose-Bisphosphate Aldolase - immunology Fructose-Bisphosphate Aldolase - metabolism Glycolysis Humans Male Mass spectroscopy Medicine Medicine & Public Health Movement disorders Movement Disorders - classification Neurodegenerative diseases Neurological diseases Neurology Neuroradiology Neurosciences Neurosurgery Original Article Parkinson's disease Probes Proteomics Psychiatry Retrospective Studies Rhythms Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Western blotting |
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Title | Proteomic identification of aldolase A as an autoantibody target in patients with atypical movement disorders |
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