Strontium Hydroxyapatite scaffolds engineered with stem cells aid osteointegration and osteogenesis in osteoporotic sheep model

Tissue engineered SrHA (cSrHA) scaffolds fabricated by seeding Adipose Derived Mesenchymal Stem Cells (ADMSCs) on Strontium incorporated Hydroxyapatite scaffolds (SrHA) promote osteogenesis and osteointegration in sheep osteoporotic bone defect model. [Display omitted] •Synergistic role of Strontium...

Full description

Saved in:
Bibliographic Details
Published inColloids and surfaces, B, Biointerfaces Vol. 163; pp. 346 - 354
Main Authors Chandran, Sunitha, Shenoy, Sachin J., Babu S., Suresh, P. Nair, Renjith, H.K., Varma, John, Annie
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2018
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Tissue engineered SrHA (cSrHA) scaffolds fabricated by seeding Adipose Derived Mesenchymal Stem Cells (ADMSCs) on Strontium incorporated Hydroxyapatite scaffolds (SrHA) promote osteogenesis and osteointegration in sheep osteoporotic bone defect model. [Display omitted] •Synergistic role of Strontium and MSCs investigated in a sheep osteoporotic model.•Porosity, radiopacity and cytocompatibility of SrHA appropriate for bone implants.•Enhanced osteogenic and osteointegrative ability depicted by cSrHA implanted group.•Proposes the use of allogenic ADMSCs for off the shelf tissue engineered products. Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been explored much. Furthermore, the present study has put forth a novel approach, wherein the synergistic action of Strontium (Sr) and MSCs in a single implant may facilitate osteoporotic bone healing. Strontium Hydroxyapatite (SrHA) synthesized by wet precipitation was fabricated into tissue engineered Strontium incorporated Hydroxyapatite (cSrHA) using sheep adipose tissue derived MSCs (ADMSCs). Porosity, radiopacity and cytocompatibility of SrHA scaffolds were found appropriate for orthopaedic applications. cSrHA scaffolds exhibited an in vitro Alkaline Phosphatase activity of 20 μmol pnp/30 min comparable to that of Hydroxyapatite (HA) – control scaffold, proving its osteogenic efficacy. Implantation studies in sheep osteoporotic model depicted enhanced osteogenic ability with mature lamellar bone formation in cSrHA implanted group, compared to bare HA, SrHA and tissue engineered HA implanted groups. Histomorphometry data substantiated improved osteogenesis on par with material resorption, as cSrHA implanted group exhibited highest regeneration ratio of 0.38 ± 0.05. Density histograms from micro CT further signified the enhanced osteointegrative ability of cSrHA implants. Results of the study depicted the therapeutic potential of cSrHA in osteoporotic bone healing and proposes the use of allogenic ADMSCs for fabricating “Off the Shelf Tissue Engineered Products”.
AbstractList Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been explored much. Furthermore, the present study has put forth a novel approach, wherein the synergistic action of Strontium (Sr) and MSCs in a single implant may facilitate osteoporotic bone healing. Strontium Hydroxyapatite (SrHA) synthesized by wet precipitation was fabricated into tissue engineered Strontium incorporated Hydroxyapatite (cSrHA) using sheep adipose tissue derived MSCs (ADMSCs). Porosity, radiopacity and cytocompatibility of SrHA scaffolds were found appropriate for orthopaedic applications. cSrHA scaffolds exhibited an in vitro Alkaline Phosphatase activity of 20 μmol pnp/30 min comparable to that of Hydroxyapatite (HA) - control scaffold, proving its osteogenic efficacy. Implantation studies in sheep osteoporotic model depicted enhanced osteogenic ability with mature lamellar bone formation in cSrHA implanted group, compared to bare HA, SrHA and tissue engineered HA implanted groups. Histomorphometry data substantiated improved osteogenesis on par with material resorption, as cSrHA implanted group exhibited highest regeneration ratio of 0.38 ± 0.05. Density histograms from micro CT further signified the enhanced osteointegrative ability of cSrHA implants. Results of the study depicted the therapeutic potential of cSrHA in osteoporotic bone healing and proposes the use of allogenic ADMSCs for fabricating "Off the Shelf Tissue Engineered Products".
Tissue engineered SrHA (cSrHA) scaffolds fabricated by seeding Adipose Derived Mesenchymal Stem Cells (ADMSCs) on Strontium incorporated Hydroxyapatite scaffolds (SrHA) promote osteogenesis and osteointegration in sheep osteoporotic bone defect model. [Display omitted] •Synergistic role of Strontium and MSCs investigated in a sheep osteoporotic model.•Porosity, radiopacity and cytocompatibility of SrHA appropriate for bone implants.•Enhanced osteogenic and osteointegrative ability depicted by cSrHA implanted group.•Proposes the use of allogenic ADMSCs for off the shelf tissue engineered products. Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been explored much. Furthermore, the present study has put forth a novel approach, wherein the synergistic action of Strontium (Sr) and MSCs in a single implant may facilitate osteoporotic bone healing. Strontium Hydroxyapatite (SrHA) synthesized by wet precipitation was fabricated into tissue engineered Strontium incorporated Hydroxyapatite (cSrHA) using sheep adipose tissue derived MSCs (ADMSCs). Porosity, radiopacity and cytocompatibility of SrHA scaffolds were found appropriate for orthopaedic applications. cSrHA scaffolds exhibited an in vitro Alkaline Phosphatase activity of 20 μmol pnp/30 min comparable to that of Hydroxyapatite (HA) – control scaffold, proving its osteogenic efficacy. Implantation studies in sheep osteoporotic model depicted enhanced osteogenic ability with mature lamellar bone formation in cSrHA implanted group, compared to bare HA, SrHA and tissue engineered HA implanted groups. Histomorphometry data substantiated improved osteogenesis on par with material resorption, as cSrHA implanted group exhibited highest regeneration ratio of 0.38 ± 0.05. Density histograms from micro CT further signified the enhanced osteointegrative ability of cSrHA implants. Results of the study depicted the therapeutic potential of cSrHA in osteoporotic bone healing and proposes the use of allogenic ADMSCs for fabricating “Off the Shelf Tissue Engineered Products”.
Author H.K., Varma
John, Annie
Chandran, Sunitha
Shenoy, Sachin J.
P. Nair, Renjith
Babu S., Suresh
Author_xml – sequence: 1
  givenname: Sunitha
  surname: Chandran
  fullname: Chandran, Sunitha
  organization: Transmission Electron Microscopy Lab, Sree Chitra Tirunal Institute for Medical Sciences & Technology, India
– sequence: 2
  givenname: Sachin J.
  surname: Shenoy
  fullname: Shenoy, Sachin J.
  organization: Division of In vivo Models & Testing, Sree Chitra Tirunal Institute for Medical Sciences & Technology, India
– sequence: 3
  givenname: Suresh
  surname: Babu S.
  fullname: Babu S., Suresh
  organization: Bioceramics Lab, Sree Chitra Tirunal Institute for Medical Sciences & Technology, India
– sequence: 4
  givenname: Renjith
  surname: P. Nair
  fullname: P. Nair, Renjith
  organization: Thrombosis Research Unit, Sree Chitra Tirunal Institute for Medical Sciences & Technology, India
– sequence: 5
  givenname: Varma
  surname: H.K.
  fullname: H.K., Varma
  organization: Bioceramics Lab, Sree Chitra Tirunal Institute for Medical Sciences & Technology, India
– sequence: 6
  givenname: Annie
  surname: John
  fullname: John, Annie
  email: ajkari@sctimst.ac.in, varma@sctimst.ac.in
  organization: Transmission Electron Microscopy Lab, Sree Chitra Tirunal Institute for Medical Sciences & Technology, India
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29331906$$D View this record in MEDLINE/PubMed
BookMark eNqFkE1v1DAQhi1URLeFv1D5yCWpP-P1DVQBRarEAThbiT3eepXYwXage-Kvk9Vue-U0mtHzzmieK3QRUwSEbihpKaHd7b61aSxL9kPLCFUtZS0R21doQ7eKN4J36gJtiGaqUaqTl-iqlD0hhAmq3qBLpjmnmnQb9Pd7zSnWsEz4_uByejr0c19DBVxs730aXcEQdyECZHD4T6iPuFSYsIVxLLgPDqe1TyFW2OU1mSLu43m4gwglFBziqZ9TTjVYXB4BZjwlB-Nb9Nr3Y4F353qNfn7-9OPuvnn49uXr3ceHxgoia8M8H7qt1hwIF9ozBYRpJz2XSjpmhYeBwSAlV5J3HByVogMqrB-803JVco3en_bOOf1aoFQzhXL8oY-QlmKo3q6ckPSIdifU5lRKBm_mHKY-Hwwl5ijf7M2zfHOUbygzq_w1eHO-sQwTuJfYs-0V-HACYP30d4Bsig0QLbiQwVbjUvjfjX9Ml57r
CitedBy_id crossref_primary_10_1021_acsabm_4c00013
crossref_primary_10_1155_2019_3673857
crossref_primary_10_1111_ijac_13625
crossref_primary_10_1039_D0BM00599A
crossref_primary_10_1007_s10047_020_01159_y
crossref_primary_10_3389_fbioe_2020_00499
crossref_primary_10_1016_j_jmrt_2023_09_239
crossref_primary_10_2147_IJN_S268657
crossref_primary_10_1016_j_dental_2019_02_023
crossref_primary_10_1016_j_ceramint_2022_08_219
crossref_primary_10_1177_08853282211027678
crossref_primary_10_3390_polym15061370
crossref_primary_10_1155_2019_4242178
crossref_primary_10_1088_1748_605X_aad923
crossref_primary_10_1038_s41413_022_00224_x
crossref_primary_10_3389_fcell_2020_614545
crossref_primary_10_1016_j_smallrumres_2018_08_002
crossref_primary_10_1186_s12903_022_02092_7
crossref_primary_10_1002_jbm_a_37108
crossref_primary_10_1017_S1431927621012976
crossref_primary_10_1016_j_ijbiomac_2019_09_107
crossref_primary_10_1016_j_msec_2021_112149
crossref_primary_10_3390_biomedicines11020325
crossref_primary_10_1016_j_biomaterials_2019_03_035
crossref_primary_10_1002_jbm_b_34989
crossref_primary_10_1016_j_biomaterials_2023_122066
crossref_primary_10_33263_Materials11_002012
crossref_primary_10_3390_molecules26154451
crossref_primary_10_1016_j_ijleo_2022_169446
crossref_primary_10_3390_coatings9050312
crossref_primary_10_1007_s00784_022_04506_w
crossref_primary_10_3390_ijms20215386
crossref_primary_10_3390_ijms25094979
crossref_primary_10_3390_ijms22126564
crossref_primary_10_3390_ijms25126805
crossref_primary_10_1088_2057_1976_ac867f
crossref_primary_10_3390_bioengineering10040414
crossref_primary_10_1039_D1TB01513C
crossref_primary_10_1016_j_jcrysgro_2022_126775
crossref_primary_10_1016_j_jcot_2018_08_003
crossref_primary_10_1016_j_jsamd_2023_100636
crossref_primary_10_3390_nano11112856
Cites_doi 10.1007/s001980200058
10.1097/01.sap.0000210629.17727.bd
10.1007/s10856-013-5018-y
10.5966/sctm.2015-0369
10.2147/IJN.S101673
10.1016/j.biomaterials.2011.08.009
10.22203/eCM.v013a01
10.1038/jcbfm.2010.220
10.1016/j.actbio.2013.04.035
10.1186/1471-2474-7-67
10.1016/S0020-1383(16)47004-X
10.1016/j.jcyt.2014.07.009
10.1039/c3tb21047b
10.1088/1748-6041/7/3/035005
10.1586/17434440.2.1.87
10.1016/j.biomaterials.2010.01.024
10.1007/s10856-014-5377-z
10.1016/j.biomaterials.2014.05.016
10.1016/j.colsurfb.2016.03.033
10.1016/j.medengphy.2008.01.007
10.1186/s12929-017-0318-z
10.1007/s10856-006-0432-z
10.1002/1097-4636(200011)52:2<270::AID-JBM5>3.0.CO;2-1
10.1089/ten.tea.2009.0472
10.1016/j.colsurfb.2016.07.012
10.1111/j.1365-2559.2012.04333.x
10.15283/ijsc.2011.4.2.99
10.1007/s00198-004-1700-8
10.3390/ijms15034714
10.1016/j.bone.2015.04.040
10.1186/1746-6148-8-169
10.1007/s11914-013-0184-x
ContentType Journal Article
Copyright 2017 Elsevier B.V.
Copyright © 2017 Elsevier B.V. All rights reserved.
Copyright_xml – notice: 2017 Elsevier B.V.
– notice: Copyright © 2017 Elsevier B.V. All rights reserved.
DBID NPM
AAYXX
CITATION
7X8
DOI 10.1016/j.colsurfb.2017.12.048
DatabaseName PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
Anatomy & Physiology
Chemistry
EISSN 1873-4367
EndPage 354
ExternalDocumentID 10_1016_j_colsurfb_2017_12_048
29331906
S0927776517308883
Genre Journal Article
GroupedDBID ---
--K
--M
-~X
.~1
0R~
1B1
1~.
1~5
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
9JM
9JN
AABXZ
AACTN
AAEDT
AAEDW
AAEPC
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AARLI
AAXUO
ABGSF
ABMAC
ABNEU
ABNUV
ABUDA
ABXRA
ABYKQ
ACDAQ
ACFVG
ACGFS
ACNCT
ACRLP
ADBBV
ADECG
ADEWK
ADEZE
ADUVX
AEBSH
AEHWI
AEKER
AEZYN
AFKWA
AFRZQ
AFTJW
AFXIZ
AFZHZ
AGHFR
AGUBO
AGYEJ
AHHHB
AHPOS
AIEXJ
AIKHN
AITUG
AIVDX
AJBFU
AJOXV
AJSZI
AKURH
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
AXJTR
BKOJK
BLXMC
CS3
DOVZS
EBS
EFJIC
EFLBG
EJD
ENUVR
EO8
EO9
EP2
EP3
F5P
FDB
FIRID
FLBIZ
FNPLU
FYGXN
G-Q
GBLVA
IHE
J1W
KOM
LX7
M24
M41
MAGPM
MO0
N9A
O-L
O9-
OAUVE
OGIMB
OZT
P-8
P-9
P2P
PC.
Q38
RIG
RNS
ROL
RPZ
SDF
SDG
SDP
SES
SPC
SSG
SSK
SSM
SSQ
SSU
SSZ
T5K
WH7
~02
~G-
AAXKI
NPM
29F
AAQXK
AAYXX
ABFNM
ABXDB
ACNNM
ADMUD
AFJKZ
AGRDE
AI.
ASPBG
AVWKF
AZFZN
BBWZM
CITATION
FEDTE
FGOYB
G-2
HLY
HVGLF
HZ~
NDZJH
R2-
SCB
SCE
SEW
SMS
VH1
WUQ
7X8
ID FETCH-LOGICAL-c405t-2f3b68993e0349f27e029d5f3575d2c4feb2eb55375363ed1546e14cfbfd95873
IEDL.DBID .~1
ISSN 0927-7765
IngestDate Fri Oct 25 09:26:49 EDT 2024
Thu Sep 26 16:11:24 EDT 2024
Wed Oct 16 00:58:11 EDT 2024
Fri Feb 23 02:31:26 EST 2024
IsPeerReviewed true
IsScholarly true
Keywords Osteoporosis
Osteoporotic sheep
Tissue engineering
Strontium Hydroxyapatite
Mesenchymal stem cells
Language English
License Copyright © 2017 Elsevier B.V. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c405t-2f3b68993e0349f27e029d5f3575d2c4feb2eb55375363ed1546e14cfbfd95873
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 29331906
PQID 1989584517
PQPubID 23479
PageCount 9
ParticipantIDs proquest_miscellaneous_1989584517
crossref_primary_10_1016_j_colsurfb_2017_12_048
pubmed_primary_29331906
elsevier_sciencedirect_doi_10_1016_j_colsurfb_2017_12_048
PublicationCentury 2000
PublicationDate 2018-03-01
PublicationDateYYYYMMDD 2018-03-01
PublicationDate_xml – month: 03
  year: 2018
  text: 2018-03-01
  day: 01
PublicationDecade 2010
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Colloids and surfaces, B, Biointerfaces
PublicationTitleAlternate Colloids Surf B Biointerfaces
PublicationYear 2018
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
References Fernandez, Shenoy, Suresh Babu, Varma, John (bib0090) 2012; 7
Ye, Zhang, Xue, Xu, Tan, Liu (bib0175) 2014; 16
Nair, Sindhu, Nair (bib0010) 2016; 1
Lill, Fluegel, Schneider (bib0075) 2002; 13
Hench (bib0110) 2006; 17
Offermanns, Andersen, Riede, Andersen, Almtoft, Sørensen (bib0015) 2016; 11
Sunitha, Harikrishnan, Annie (bib0025) 2017; 7
Grzesiak, Krzysztof, Karol, Joanna (bib0065) 2011; 4
Dudas, Marra, Cooper, Penascino, Mooney, Jiang (bib0140) 2006; 56
Schubert, Xhema, Vériter, Schubert, Behets, Delloye (bib0040) 2011; 32
Meka, Jain, Chatterjee (bib0120) 2016; 1
Kaibuchi, Iwata, Yamato, Okano, Ando (bib0035) 2016
Vériter, André, Aouassar, Poirel, Lafosse, Docquier (bib0045) 2015
Antebi, Pelled, Gazit (bib0030) 2014; 12
Mirsaidi, Genelin, Vetsch, Stanger, Theiss, Lindtner (bib0050) 2014; 35
Nuss, Auer, Boos, von Rechenberg (bib0085) 2006; 7
Lyahyai, Mediano, Ranera, Sanz, Remacha, Bolea (bib0070) 2012; 8
Kilkenny, Browne, Cuthill, Emerson, Altman (bib0055) 2011; 31
Berner, Reichert, Woodruff, Saifzadeh, Morris, Epari (bib0160) 2013; 9
Pei, Li, McConda, Wen, Clovis, Danley (bib0135) 2015; 78
Tao, Bai, He, Liu, Li, Zhou (bib0185) 2016
Zhang, Wei, Chang, Miron, Shi, Yi (bib0115) 2013; 1
El-Ghannam (bib0130) 2005; 2
Zreiqat, Ramaswamy, Wu, Paschalidis, Lu, James (bib0180) 2010; 31
Chang, Stanford, Keller (bib0165) 2000; 52
Yuan, Zhang, Liu, Wei, Qi, Liu (bib0170) 2010; 16
Mohan, Suresh Babu, Varma, John (bib0060) 2013; 24
Pak, Lee, Park, Park, Kang, Lee (bib0155) 2017; 24
Boyd, Rutledge, Randolph, Mutreja, Meenan (bib0100) 2015; 26
Egan, Brennan, Pignolo (bib0095) 2012; 61
Cheung, Miclau, SK-H, Yang, Alt (bib0125) 2016; 47
Wu, Lei, Hu, Wang, Wan, Ma (bib0145) 2008; 30
Gao, Deng, Feng, Mao, Li, Yang (bib0105) 2014; 15
Prins, Schulten, Ten Bruggenkate, Klein-Nulend, Helder (bib0150) 2016; 5
Dreinhöfer, Anderson, Féron, Herrera, Hube, Johnell (bib0005) 2005; 16
Pearce, Richards, Milz, Schneider, Pearce (bib0080) 2007; 13
Chandran, S, Vs, Varma, John (bib0020) 2016
Nair (10.1016/j.colsurfb.2017.12.048_bib0010) 2016; 1
Pak (10.1016/j.colsurfb.2017.12.048_bib0155) 2017; 24
Prins (10.1016/j.colsurfb.2017.12.048_bib0150) 2016; 5
Meka (10.1016/j.colsurfb.2017.12.048_bib0120) 2016; 1
Pei (10.1016/j.colsurfb.2017.12.048_bib0135) 2015; 78
Lill (10.1016/j.colsurfb.2017.12.048_bib0075) 2002; 13
Wu (10.1016/j.colsurfb.2017.12.048_bib0145) 2008; 30
Antebi (10.1016/j.colsurfb.2017.12.048_bib0030) 2014; 12
Egan (10.1016/j.colsurfb.2017.12.048_bib0095) 2012; 61
Ye (10.1016/j.colsurfb.2017.12.048_bib0175) 2014; 16
Yuan (10.1016/j.colsurfb.2017.12.048_bib0170) 2010; 16
Gao (10.1016/j.colsurfb.2017.12.048_bib0105) 2014; 15
Kaibuchi (10.1016/j.colsurfb.2017.12.048_bib0035) 2016
Tao (10.1016/j.colsurfb.2017.12.048_bib0185) 2016
Vériter (10.1016/j.colsurfb.2017.12.048_bib0045) 2015
Lyahyai (10.1016/j.colsurfb.2017.12.048_bib0070) 2012; 8
Dudas (10.1016/j.colsurfb.2017.12.048_bib0140) 2006; 56
Offermanns (10.1016/j.colsurfb.2017.12.048_bib0015) 2016; 11
Berner (10.1016/j.colsurfb.2017.12.048_bib0160) 2013; 9
Fernandez (10.1016/j.colsurfb.2017.12.048_bib0090) 2012; 7
Zhang (10.1016/j.colsurfb.2017.12.048_bib0115) 2013; 1
Grzesiak (10.1016/j.colsurfb.2017.12.048_bib0065) 2011; 4
Dreinhöfer (10.1016/j.colsurfb.2017.12.048_bib0005) 2005; 16
El-Ghannam (10.1016/j.colsurfb.2017.12.048_bib0130) 2005; 2
Boyd (10.1016/j.colsurfb.2017.12.048_bib0100) 2015; 26
Chandran (10.1016/j.colsurfb.2017.12.048_bib0020) 2016
Pearce (10.1016/j.colsurfb.2017.12.048_bib0080) 2007; 13
Kilkenny (10.1016/j.colsurfb.2017.12.048_bib0055) 2011; 31
Nuss (10.1016/j.colsurfb.2017.12.048_bib0085) 2006; 7
Chang (10.1016/j.colsurfb.2017.12.048_bib0165) 2000; 52
Hench (10.1016/j.colsurfb.2017.12.048_bib0110) 2006; 17
Zreiqat (10.1016/j.colsurfb.2017.12.048_bib0180) 2010; 31
Mohan (10.1016/j.colsurfb.2017.12.048_bib0060) 2013; 24
Schubert (10.1016/j.colsurfb.2017.12.048_bib0040) 2011; 32
Sunitha (10.1016/j.colsurfb.2017.12.048_bib0025) 2017; 7
Mirsaidi (10.1016/j.colsurfb.2017.12.048_bib0050) 2014; 35
Cheung (10.1016/j.colsurfb.2017.12.048_bib0125) 2016; 47
References_xml – volume: 30
  start-page: 1112
  year: 2008
  end-page: 1118
  ident: bib0145
  article-title: Effect of ovariectomy on BMD, micro-architecture and biomechanics of cortical and cancellous bones in a sheep model
  publication-title: Med. Eng. Phys.
  contributor:
    fullname: Ma
– year: 2016
  ident: bib0020
  article-title: Osteogenic efficacy of strontium hydroxyapatite micro-granules in osteoporotic rat model
  publication-title: J. Biomater. Appl.
  contributor:
    fullname: John
– volume: 35
  start-page: 7326
  year: 2014
  end-page: 7335
  ident: bib0050
  article-title: Therapeutic potential of adipose-derived stromal cells in age-related osteoporosis
  publication-title: Biomaterials
  contributor:
    fullname: Lindtner
– volume: 24
  start-page: 2831
  year: 2013
  end-page: 2844
  ident: bib0060
  article-title: In vitro evaluation of bioactive strontium-based ceramic with rabbit adipose-derived stem cells for bone tissue regeneration
  publication-title: J. Mater. Sci. Mater. Med.
  contributor:
    fullname: John
– volume: 2
  start-page: 87
  year: 2005
  end-page: 101
  ident: bib0130
  article-title: Bone reconstruction: from bioceramics to tissue engineering
  publication-title: Expert Rev. Med. Devices
  contributor:
    fullname: El-Ghannam
– volume: 9
  start-page: 7874
  year: 2013
  end-page: 7884
  ident: bib0160
  article-title: Autologous vs. allogenic mesenchymal progenitor cells for the reconstruction of critical sized segmental tibial bone defects in aged sheep
  publication-title: Acta Biomater.
  contributor:
    fullname: Epari
– volume: 61
  start-page: 1168
  year: 2012
  end-page: 1173
  ident: bib0095
  article-title: Bone histomorphometry using free and commonly available software
  publication-title: Histopathology
  contributor:
    fullname: Pignolo
– year: 2016
  ident: bib0035
  article-title: Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model
  publication-title: Acta Biomater.
  contributor:
    fullname: Ando
– volume: 5
  start-page: 1362
  year: 2016
  end-page: 1374
  ident: bib0150
  article-title: Bone regeneration using the freshly isolated autologous stromal vascular fraction of adipose tissue in combination with calcium phosphate ceramics
  publication-title: Stem Cells Transl. Med.
  contributor:
    fullname: Helder
– volume: 26
  start-page: 65
  year: 2015
  ident: bib0100
  article-title: The deposition of strontium-substituted hydroxyapatite coatings
  publication-title: J. Mater. Sci. Mater. Med.
  contributor:
    fullname: Meenan
– volume: 1
  start-page: 5711
  year: 2013
  end-page: 5722
  ident: bib0115
  article-title: Strontium-incorporated mesoporous bioactive glass scaffolds stimulating in vitro proliferation and differentiation of bone marrow stromal cells and in vivo regeneration of osteoporotic bone defects
  publication-title: J. Mater. Chem. B
  contributor:
    fullname: Yi
– volume: 78
  start-page: 1
  year: 2015
  end-page: 10
  ident: bib0135
  article-title: A comparison of tissue engineering based repair of calvarial defects using adipose stem cells from normal and osteoporotic rats
  publication-title: Bone
  contributor:
    fullname: Danley
– volume: 56
  start-page: 543
  year: 2006
  end-page: 548
  ident: bib0140
  article-title: The osteogenic potential of adipose-derived stem cells for the repair of rabbit calvarial defects
  publication-title: Ann. Plast. Surg.
  contributor:
    fullname: Jiang
– volume: 16
  start-page: 1643
  year: 2014
  end-page: 1655
  ident: bib0175
  article-title: Adipose-derived stem cells alleviate osteoporosis by enhancing osteogenesis and inhibiting adipogenesis in a rabbit model
  publication-title: Cytotherapy
  contributor:
    fullname: Liu
– year: 2015
  ident: bib0045
  article-title: Human adipose-Derived mesenchymal stem cells in cell therapy: safety and feasibility in different hospital exemption clinical applications
  publication-title: PLoS One
  contributor:
    fullname: Docquier
– volume: 13
  start-page: 1
  year: 2007
  end-page: 10
  ident: bib0080
  article-title: Animal models for implant biomaterial research in bone: a review
  publication-title: Eur. Cell Mater.
  contributor:
    fullname: Pearce
– volume: 12
  start-page: 41
  year: 2014
  end-page: 47
  ident: bib0030
  article-title: Stem cell therapy for osteoporosis
  publication-title: Curr. Osteoporos Rep.
  contributor:
    fullname: Gazit
– volume: 7
  start-page: 035005
  year: 2012
  ident: bib0090
  article-title: Short-term studies using ceramic scaffolds in lapine model for osteochondral defect amelioration
  publication-title: Biomed. Mater. Bristol. Engl.
  contributor:
    fullname: John
– volume: 31
  start-page: 3175
  year: 2010
  end-page: 3184
  ident: bib0180
  article-title: The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering
  publication-title: Biomaterials
  contributor:
    fullname: James
– volume: 47
  start-page: S21
  year: 2016
  end-page: 26
  ident: bib0125
  article-title: Fracture healing in osteoporotic bone
  publication-title: Injury
  contributor:
    fullname: Alt
– volume: 32
  start-page: 8880
  year: 2011
  end-page: 8891
  ident: bib0040
  article-title: The enhanced performance of bone allografts using osteogenic-differentiated adipose-derived mesenchymal stem cells
  publication-title: Biomaterials
  contributor:
    fullname: Delloye
– volume: 16
  start-page: S44
  year: 2005
  end-page: S53
  ident: bib0005
  article-title: Multinational survey of osteoporotic fracture management
  publication-title: Osteoporos Int.
  contributor:
    fullname: Johnell
– volume: 8
  start-page: 169
  year: 2012
  ident: bib0070
  article-title: Isolation and characterization of ovine mesenchymal stem cells derived from peripheral blood
  publication-title: BMC Vet. Res.
  contributor:
    fullname: Bolea
– volume: 1
  start-page: 649
  year: 2016
  end-page: 656
  ident: bib0120
  article-title: Strontium eluting nanofibers augment stem cell osteogenesis for bone tissue regeneration
  publication-title: Colloids Surf. B Biointerfaces
  contributor:
    fullname: Chatterjee
– volume: 15
  start-page: 4714
  year: 2014
  end-page: 4732
  ident: bib0105
  article-title: Current progress in bioactive ceramic scaffolds for bone repair and regeneration
  publication-title: Int. J. Mol. Sci.
  contributor:
    fullname: Yang
– volume: 16
  start-page: 1385
  year: 2010
  end-page: 1394
  ident: bib0170
  article-title: Repair of canine mandibular bone defects with bone marrow stromal cells and coral
  publication-title: Tissue Eng. Part A
  contributor:
    fullname: Liu
– volume: 1
  start-page: 423
  year: 2016
  end-page: 430
  ident: bib0010
  article-title: Polycaprolactone-laponite composite scaffold releasing strontium ranelate for bone tissue engineering applications
  publication-title: Colloids Surf. B Biointerfaces
  contributor:
    fullname: Nair
– volume: 7
  start-page: 67
  year: 2006
  ident: bib0085
  article-title: An animal model in sheep for biocompatibility testing of biomaterials in cancellous bones
  publication-title: BMC Musculoskelet Disord.
  contributor:
    fullname: von Rechenberg
– volume: 17
  start-page: 967
  year: 2006
  end-page: 978
  ident: bib0110
  article-title: The story of bioglass
  publication-title: J. Mater. Sci. Mater. Med.
  contributor:
    fullname: Hench
– volume: 7
  start-page: 36
  year: 2017
  end-page: 43
  ident: bib0025
  article-title: Ovariectomised and long term induced (OLI) rat model for preclinical assessment of osteoporotic therapeutics
  publication-title: J. Drug Deliv. Ther.
  contributor:
    fullname: Annie
– volume: 52
  start-page: 270
  year: 2000
  end-page: 278
  ident: bib0165
  article-title: Calcium and phosphate supplementation promotes bone cell mineralization: implications for hydroxyapatite (HA)-enhanced bone formation
  publication-title: J. Biomed. Mater. Res.
  contributor:
    fullname: Keller
– volume: 11
  start-page: 2431
  year: 2016
  end-page: 2442
  ident: bib0015
  article-title: Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats
  publication-title: Int. J. Nanomed.
  contributor:
    fullname: Sørensen
– year: 2016
  ident: bib0185
  article-title: A comparative study of strontium-substituted hydroxyapatite coating on implant’s osseointegration for osteopenic rats
  publication-title: Med. Biol. Eng. Comput.
  contributor:
    fullname: Zhou
– volume: 31
  start-page: 991
  year: 2011
  end-page: 993
  ident: bib0055
  article-title: National centre for the replacement, refinement and reduction of amimals in research. Animal research: reporting in vivo experiments–the ARRIVE guidelines
  publication-title: J. Cereb. Blood Flow Metab.
  contributor:
    fullname: Altman
– volume: 4
  start-page: 99
  year: 2011
  end-page: 104
  ident: bib0065
  article-title: Isolation and morphological characterisation of ovine adipose-derived mesenchymal stem cells in culture
  publication-title: Int. J. Stem Cells
  contributor:
    fullname: Joanna
– volume: 24
  start-page: 9
  year: 2017
  ident: bib0155
  article-title: Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications
  publication-title: J. Biomed. Sci.
  contributor:
    fullname: Lee
– volume: 13
  start-page: 480
  year: 2002
  end-page: 486
  ident: bib0075
  article-title: Effect of ovariectomy, malnutrition and glucocorticoid application on bone properties in sheep: a pilot study
  publication-title: Osteoporos Int.
  contributor:
    fullname: Schneider
– volume: 13
  start-page: 480
  issue: 6
  year: 2002
  ident: 10.1016/j.colsurfb.2017.12.048_bib0075
  article-title: Effect of ovariectomy, malnutrition and glucocorticoid application on bone properties in sheep: a pilot study
  publication-title: Osteoporos Int.
  doi: 10.1007/s001980200058
  contributor:
    fullname: Lill
– volume: 56
  start-page: 543
  issue: May (5)
  year: 2006
  ident: 10.1016/j.colsurfb.2017.12.048_bib0140
  article-title: The osteogenic potential of adipose-derived stem cells for the repair of rabbit calvarial defects
  publication-title: Ann. Plast. Surg.
  doi: 10.1097/01.sap.0000210629.17727.bd
  contributor:
    fullname: Dudas
– volume: 24
  start-page: 2831
  issue: December (12)
  year: 2013
  ident: 10.1016/j.colsurfb.2017.12.048_bib0060
  article-title: In vitro evaluation of bioactive strontium-based ceramic with rabbit adipose-derived stem cells for bone tissue regeneration
  publication-title: J. Mater. Sci. Mater. Med.
  doi: 10.1007/s10856-013-5018-y
  contributor:
    fullname: Mohan
– volume: 5
  start-page: 1362
  issue: 10
  year: 2016
  ident: 10.1016/j.colsurfb.2017.12.048_bib0150
  article-title: Bone regeneration using the freshly isolated autologous stromal vascular fraction of adipose tissue in combination with calcium phosphate ceramics
  publication-title: Stem Cells Transl. Med.
  doi: 10.5966/sctm.2015-0369
  contributor:
    fullname: Prins
– volume: 11
  start-page: 2431
  year: 2016
  ident: 10.1016/j.colsurfb.2017.12.048_bib0015
  article-title: Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S101673
  contributor:
    fullname: Offermanns
– volume: 32
  start-page: 8880
  issue: December (34)
  year: 2011
  ident: 10.1016/j.colsurfb.2017.12.048_bib0040
  article-title: The enhanced performance of bone allografts using osteogenic-differentiated adipose-derived mesenchymal stem cells
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2011.08.009
  contributor:
    fullname: Schubert
– issue: April
  year: 2016
  ident: 10.1016/j.colsurfb.2017.12.048_bib0185
  article-title: A comparative study of strontium-substituted hydroxyapatite coating on implant’s osseointegration for osteopenic rats
  publication-title: Med. Biol. Eng. Comput.
  contributor:
    fullname: Tao
– volume: 13
  start-page: 1
  year: 2007
  ident: 10.1016/j.colsurfb.2017.12.048_bib0080
  article-title: Animal models for implant biomaterial research in bone: a review
  publication-title: Eur. Cell Mater.
  doi: 10.22203/eCM.v013a01
  contributor:
    fullname: Pearce
– volume: 31
  start-page: 991
  issue: April (4)
  year: 2011
  ident: 10.1016/j.colsurfb.2017.12.048_bib0055
  article-title: National centre for the replacement, refinement and reduction of amimals in research. Animal research: reporting in vivo experiments–the ARRIVE guidelines
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1038/jcbfm.2010.220
  contributor:
    fullname: Kilkenny
– volume: 9
  start-page: 7874
  issue: August (8)
  year: 2013
  ident: 10.1016/j.colsurfb.2017.12.048_bib0160
  article-title: Autologous vs. allogenic mesenchymal progenitor cells for the reconstruction of critical sized segmental tibial bone defects in aged sheep
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2013.04.035
  contributor:
    fullname: Berner
– volume: 7
  start-page: 67
  year: 2006
  ident: 10.1016/j.colsurfb.2017.12.048_bib0085
  article-title: An animal model in sheep for biocompatibility testing of biomaterials in cancellous bones
  publication-title: BMC Musculoskelet Disord.
  doi: 10.1186/1471-2474-7-67
  contributor:
    fullname: Nuss
– volume: 47
  start-page: S21
  issue: June (Suppl. 2)
  year: 2016
  ident: 10.1016/j.colsurfb.2017.12.048_bib0125
  article-title: Fracture healing in osteoporotic bone
  publication-title: Injury
  doi: 10.1016/S0020-1383(16)47004-X
  contributor:
    fullname: Cheung
– volume: 16
  start-page: 1643
  issue: December (12)
  year: 2014
  ident: 10.1016/j.colsurfb.2017.12.048_bib0175
  article-title: Adipose-derived stem cells alleviate osteoporosis by enhancing osteogenesis and inhibiting adipogenesis in a rabbit model
  publication-title: Cytotherapy
  doi: 10.1016/j.jcyt.2014.07.009
  contributor:
    fullname: Ye
– volume: 1
  start-page: 5711
  issue: October (41)
  year: 2013
  ident: 10.1016/j.colsurfb.2017.12.048_bib0115
  article-title: Strontium-incorporated mesoporous bioactive glass scaffolds stimulating in vitro proliferation and differentiation of bone marrow stromal cells and in vivo regeneration of osteoporotic bone defects
  publication-title: J. Mater. Chem. B
  doi: 10.1039/c3tb21047b
  contributor:
    fullname: Zhang
– issue: May
  year: 2016
  ident: 10.1016/j.colsurfb.2017.12.048_bib0020
  article-title: Osteogenic efficacy of strontium hydroxyapatite micro-granules in osteoporotic rat model
  publication-title: J. Biomater. Appl.
  contributor:
    fullname: Chandran
– volume: 7
  start-page: 035005
  issue: June (3)
  year: 2012
  ident: 10.1016/j.colsurfb.2017.12.048_bib0090
  article-title: Short-term studies using ceramic scaffolds in lapine model for osteochondral defect amelioration
  publication-title: Biomed. Mater. Bristol. Engl.
  doi: 10.1088/1748-6041/7/3/035005
  contributor:
    fullname: Fernandez
– volume: 2
  start-page: 87
  issue: January (1)
  year: 2005
  ident: 10.1016/j.colsurfb.2017.12.048_bib0130
  article-title: Bone reconstruction: from bioceramics to tissue engineering
  publication-title: Expert Rev. Med. Devices
  doi: 10.1586/17434440.2.1.87
  contributor:
    fullname: El-Ghannam
– volume: 31
  start-page: 3175
  issue: April (12)
  year: 2010
  ident: 10.1016/j.colsurfb.2017.12.048_bib0180
  article-title: The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2010.01.024
  contributor:
    fullname: Zreiqat
– volume: 26
  start-page: 65
  issue: February (2)
  year: 2015
  ident: 10.1016/j.colsurfb.2017.12.048_bib0100
  article-title: The deposition of strontium-substituted hydroxyapatite coatings
  publication-title: J. Mater. Sci. Mater. Med.
  doi: 10.1007/s10856-014-5377-z
  contributor:
    fullname: Boyd
– volume: 35
  start-page: 7326
  issue: August (26)
  year: 2014
  ident: 10.1016/j.colsurfb.2017.12.048_bib0050
  article-title: Therapeutic potential of adipose-derived stromal cells in age-related osteoporosis
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2014.05.016
  contributor:
    fullname: Mirsaidi
– volume: 1
  start-page: 423
  issue: July (143)
  year: 2016
  ident: 10.1016/j.colsurfb.2017.12.048_bib0010
  article-title: Polycaprolactone-laponite composite scaffold releasing strontium ranelate for bone tissue engineering applications
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2016.03.033
  contributor:
    fullname: Nair
– issue: October
  year: 2015
  ident: 10.1016/j.colsurfb.2017.12.048_bib0045
  article-title: Human adipose-Derived mesenchymal stem cells in cell therapy: safety and feasibility in different hospital exemption clinical applications
  publication-title: PLoS One
  contributor:
    fullname: Vériter
– volume: 30
  start-page: 1112
  issue: November (9)
  year: 2008
  ident: 10.1016/j.colsurfb.2017.12.048_bib0145
  article-title: Effect of ovariectomy on BMD, micro-architecture and biomechanics of cortical and cancellous bones in a sheep model
  publication-title: Med. Eng. Phys.
  doi: 10.1016/j.medengphy.2008.01.007
  contributor:
    fullname: Wu
– volume: 24
  start-page: 9
  issue: January (1)
  year: 2017
  ident: 10.1016/j.colsurfb.2017.12.048_bib0155
  article-title: Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications
  publication-title: J. Biomed. Sci.
  doi: 10.1186/s12929-017-0318-z
  contributor:
    fullname: Pak
– volume: 17
  start-page: 967
  issue: November (11)
  year: 2006
  ident: 10.1016/j.colsurfb.2017.12.048_bib0110
  article-title: The story of bioglass
  publication-title: J. Mater. Sci. Mater. Med.
  doi: 10.1007/s10856-006-0432-z
  contributor:
    fullname: Hench
– volume: 52
  start-page: 270
  issue: November (2)
  year: 2000
  ident: 10.1016/j.colsurfb.2017.12.048_bib0165
  article-title: Calcium and phosphate supplementation promotes bone cell mineralization: implications for hydroxyapatite (HA)-enhanced bone formation
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/1097-4636(200011)52:2<270::AID-JBM5>3.0.CO;2-1
  contributor:
    fullname: Chang
– volume: 16
  start-page: 1385
  issue: April (4)
  year: 2010
  ident: 10.1016/j.colsurfb.2017.12.048_bib0170
  article-title: Repair of canine mandibular bone defects with bone marrow stromal cells and coral
  publication-title: Tissue Eng. Part A
  doi: 10.1089/ten.tea.2009.0472
  contributor:
    fullname: Yuan
– volume: 1
  start-page: 649
  issue: October (146
  year: 2016
  ident: 10.1016/j.colsurfb.2017.12.048_bib0120
  article-title: Strontium eluting nanofibers augment stem cell osteogenesis for bone tissue regeneration
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2016.07.012
  contributor:
    fullname: Meka
– volume: 61
  start-page: 1168
  issue: December (6)
  year: 2012
  ident: 10.1016/j.colsurfb.2017.12.048_bib0095
  article-title: Bone histomorphometry using free and commonly available software
  publication-title: Histopathology
  doi: 10.1111/j.1365-2559.2012.04333.x
  contributor:
    fullname: Egan
– volume: 4
  start-page: 99
  issue: November (2)
  year: 2011
  ident: 10.1016/j.colsurfb.2017.12.048_bib0065
  article-title: Isolation and morphological characterisation of ovine adipose-derived mesenchymal stem cells in culture
  publication-title: Int. J. Stem Cells
  doi: 10.15283/ijsc.2011.4.2.99
  contributor:
    fullname: Grzesiak
– volume: 16
  start-page: S44
  issue: March (Suppl. 2)
  year: 2005
  ident: 10.1016/j.colsurfb.2017.12.048_bib0005
  article-title: Multinational survey of osteoporotic fracture management
  publication-title: Osteoporos Int.
  doi: 10.1007/s00198-004-1700-8
  contributor:
    fullname: Dreinhöfer
– issue: June
  year: 2016
  ident: 10.1016/j.colsurfb.2017.12.048_bib0035
  article-title: Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model
  publication-title: Acta Biomater.
  contributor:
    fullname: Kaibuchi
– volume: 15
  start-page: 4714
  issue: March (3)
  year: 2014
  ident: 10.1016/j.colsurfb.2017.12.048_bib0105
  article-title: Current progress in bioactive ceramic scaffolds for bone repair and regeneration
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms15034714
  contributor:
    fullname: Gao
– volume: 78
  start-page: 1
  issue: September
  year: 2015
  ident: 10.1016/j.colsurfb.2017.12.048_bib0135
  article-title: A comparison of tissue engineering based repair of calvarial defects using adipose stem cells from normal and osteoporotic rats
  publication-title: Bone
  doi: 10.1016/j.bone.2015.04.040
  contributor:
    fullname: Pei
– volume: 7
  start-page: 36
  issue: March (2)
  year: 2017
  ident: 10.1016/j.colsurfb.2017.12.048_bib0025
  article-title: Ovariectomised and long term induced (OLI) rat model for preclinical assessment of osteoporotic therapeutics
  publication-title: J. Drug Deliv. Ther.
  contributor:
    fullname: Sunitha
– volume: 8
  start-page: 169
  issue: September
  year: 2012
  ident: 10.1016/j.colsurfb.2017.12.048_bib0070
  article-title: Isolation and characterization of ovine mesenchymal stem cells derived from peripheral blood
  publication-title: BMC Vet. Res.
  doi: 10.1186/1746-6148-8-169
  contributor:
    fullname: Lyahyai
– volume: 12
  start-page: 41
  issue: March (1)
  year: 2014
  ident: 10.1016/j.colsurfb.2017.12.048_bib0030
  article-title: Stem cell therapy for osteoporosis
  publication-title: Curr. Osteoporos Rep.
  doi: 10.1007/s11914-013-0184-x
  contributor:
    fullname: Antebi
SSID ssj0002417
Score 2.4554935
Snippet Tissue engineered SrHA (cSrHA) scaffolds fabricated by seeding Adipose Derived Mesenchymal Stem Cells (ADMSCs) on Strontium incorporated Hydroxyapatite...
Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies...
SourceID proquest
crossref
pubmed
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 346
SubjectTerms Mesenchymal stem cells
Osteoporosis
Osteoporotic sheep
Strontium Hydroxyapatite
Tissue engineering
Title Strontium Hydroxyapatite scaffolds engineered with stem cells aid osteointegration and osteogenesis in osteoporotic sheep model
URI https://dx.doi.org/10.1016/j.colsurfb.2017.12.048
https://www.ncbi.nlm.nih.gov/pubmed/29331906
https://search.proquest.com/docview/1989584517
Volume 163
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3BTtwwEB0hemh7qMpSyhaKXKnqLeyu7Tib42oFWlp1LxSJm-XENg2CZEWyBy7trzPjJO1WAvXA0ZaTWHmjmTej5zHAZ5twbmIho1hkPpIu9RHGeRsZj_FwMiVlDZUGvi_V4kJ-vYwvt2Den4UhWWXn-1ufHrx1NzPq_uZoVRSj83HKkyRR8QSNFPM46vgpMfyhTR__-ivzwAgVjkzj4ohWb5wSvsZ339TrO5-RxCsJZUG6B-jxAPUUAQ2B6PQtvOkYJJu1m9yBLVcOYHdWYvZ8e8--sKDpDMXyAbyc9_e5DeD1RuvBXfh9TjXwpljfssW9JS2LIW1141idG--rG1sz1z3gLKNyLaOez4wq_TUzhWV0PKTq200gvMyU3eQVOdCiZkXZjpHjV7hbVv90bsXC5Tvv4OL05Md8EXWXMUQ5crom4l5kCpMz4aijjeeJG_PUxl4g37M8lx5TdJfFscD8RwlnkZopN5G5z7xN42ki9mC7rEq3Dyw1OKVwylkppRgbnuSK52aah3xJDWHUI6BXbc8N3YvRrnWPmSbM9IRrxGwIaQ-U_sd6NAaG_z77qUdWIyL0F03pqnWtSU6G_AwNbAjvW8j_7AdZEjqvsfrwjC8fwCscTVtF2yFsN3dr9xEpTpMdBRs-ghezs2-L5QNqdP4v
link.rule.ids 315,783,787,4509,24128,27936,27937,45597,45691
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1NT9wwEB1ROFAOFSxt2VJaV6p6S3fXdpzNEa1AWwpcAImb5cQ2DYJkRbIHLu1fZ8ZJCpWoeugxzpflN5p5M3oeA3y2CecmFjKKReYj6VIfYZy3kfEYDydTUtZQaeDkVM0v5NFlfLkCs34vDMkqO9_f-vTgrbuRUbeao0VRjM7GKU-SRMUTNFLM48QLWJPEj9Gov_581HlgiAp7pvHpiB5_sk34Gj9-Uy_vfEYaryTUBekgoOcj1N8YaIhEh5vwqqOQbL-d5RasuHIA2_slps-39-wLC6LOUC0fwPqsP9BtABtPeg9uw68zKoI3xfKWze8tiVkMiasbx-rceF_d2Jq57gVnGdVrGTV9ZlTqr5kpLKP9IVXfbwLxZabsBq_IgxY1K8r2Gkl-hbNl9Q_nFiycvvMaLg4PzmfzqDuNIcqR1DUR9yJTmJ0JRy1tPE_cmKc29gIJn-W59JijuyyOBSZASjiL3Ey5icx95m0aTxPxBlbLqnQ7wFKDQwqHnJVSirHhSa54bqZ5SJjUEEY9AnrRNt3QvRrtWveYacJMT7hGzIaQ9kDpP8xHY2T457ufemQ1IkKraEpXLWtNejIkaGhhQ3jbQv57PkiT0HuN1bv_-PNHWJ-fnxzr42-n33fhJd6ZtvK297Da3C3dHvKdJvsQ7PkBSbn_yA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Strontium+Hydroxyapatite+scaffolds+engineered+with+stem+cells+aid+osteointegration+and+osteogenesis+in+osteoporotic+sheep+model&rft.jtitle=Colloids+and+surfaces%2C+B%2C+Biointerfaces&rft.au=Chandran%2C+Sunitha&rft.au=Shenoy%2C+Sachin+J&rft.au=Babu+S%2C+Suresh&rft.au=P+Nair%2C+Renjith&rft.date=2018-03-01&rft.eissn=1873-4367&rft.volume=163&rft.spage=346&rft_id=info:doi/10.1016%2Fj.colsurfb.2017.12.048&rft_id=info%3Apmid%2F29331906&rft.externalDocID=29331906
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0927-7765&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0927-7765&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0927-7765&client=summon