Strontium Hydroxyapatite scaffolds engineered with stem cells aid osteointegration and osteogenesis in osteoporotic sheep model
Tissue engineered SrHA (cSrHA) scaffolds fabricated by seeding Adipose Derived Mesenchymal Stem Cells (ADMSCs) on Strontium incorporated Hydroxyapatite scaffolds (SrHA) promote osteogenesis and osteointegration in sheep osteoporotic bone defect model. [Display omitted] •Synergistic role of Strontium...
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Published in | Colloids and surfaces, B, Biointerfaces Vol. 163; pp. 346 - 354 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.03.2018
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Abstract | Tissue engineered SrHA (cSrHA) scaffolds fabricated by seeding Adipose Derived Mesenchymal Stem Cells (ADMSCs) on Strontium incorporated Hydroxyapatite scaffolds (SrHA) promote osteogenesis and osteointegration in sheep osteoporotic bone defect model.
[Display omitted]
•Synergistic role of Strontium and MSCs investigated in a sheep osteoporotic model.•Porosity, radiopacity and cytocompatibility of SrHA appropriate for bone implants.•Enhanced osteogenic and osteointegrative ability depicted by cSrHA implanted group.•Proposes the use of allogenic ADMSCs for off the shelf tissue engineered products.
Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been explored much. Furthermore, the present study has put forth a novel approach, wherein the synergistic action of Strontium (Sr) and MSCs in a single implant may facilitate osteoporotic bone healing.
Strontium Hydroxyapatite (SrHA) synthesized by wet precipitation was fabricated into tissue engineered Strontium incorporated Hydroxyapatite (cSrHA) using sheep adipose tissue derived MSCs (ADMSCs). Porosity, radiopacity and cytocompatibility of SrHA scaffolds were found appropriate for orthopaedic applications. cSrHA scaffolds exhibited an in vitro Alkaline Phosphatase activity of 20 μmol pnp/30 min comparable to that of Hydroxyapatite (HA) – control scaffold, proving its osteogenic efficacy. Implantation studies in sheep osteoporotic model depicted enhanced osteogenic ability with mature lamellar bone formation in cSrHA implanted group, compared to bare HA, SrHA and tissue engineered HA implanted groups. Histomorphometry data substantiated improved osteogenesis on par with material resorption, as cSrHA implanted group exhibited highest regeneration ratio of 0.38 ± 0.05. Density histograms from micro CT further signified the enhanced osteointegrative ability of cSrHA implants. Results of the study depicted the therapeutic potential of cSrHA in osteoporotic bone healing and proposes the use of allogenic ADMSCs for fabricating “Off the Shelf Tissue Engineered Products”. |
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AbstractList | Tissue engineered SrHA (cSrHA) scaffolds fabricated by seeding Adipose Derived Mesenchymal Stem Cells (ADMSCs) on Strontium incorporated Hydroxyapatite scaffolds (SrHA) promote osteogenesis and osteointegration in sheep osteoporotic bone defect model.
[Display omitted]
•Synergistic role of Strontium and MSCs investigated in a sheep osteoporotic model.•Porosity, radiopacity and cytocompatibility of SrHA appropriate for bone implants.•Enhanced osteogenic and osteointegrative ability depicted by cSrHA implanted group.•Proposes the use of allogenic ADMSCs for off the shelf tissue engineered products.
Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been explored much. Furthermore, the present study has put forth a novel approach, wherein the synergistic action of Strontium (Sr) and MSCs in a single implant may facilitate osteoporotic bone healing.
Strontium Hydroxyapatite (SrHA) synthesized by wet precipitation was fabricated into tissue engineered Strontium incorporated Hydroxyapatite (cSrHA) using sheep adipose tissue derived MSCs (ADMSCs). Porosity, radiopacity and cytocompatibility of SrHA scaffolds were found appropriate for orthopaedic applications. cSrHA scaffolds exhibited an in vitro Alkaline Phosphatase activity of 20 μmol pnp/30 min comparable to that of Hydroxyapatite (HA) – control scaffold, proving its osteogenic efficacy. Implantation studies in sheep osteoporotic model depicted enhanced osteogenic ability with mature lamellar bone formation in cSrHA implanted group, compared to bare HA, SrHA and tissue engineered HA implanted groups. Histomorphometry data substantiated improved osteogenesis on par with material resorption, as cSrHA implanted group exhibited highest regeneration ratio of 0.38 ± 0.05. Density histograms from micro CT further signified the enhanced osteointegrative ability of cSrHA implants. Results of the study depicted the therapeutic potential of cSrHA in osteoporotic bone healing and proposes the use of allogenic ADMSCs for fabricating “Off the Shelf Tissue Engineered Products”. Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been explored much. Furthermore, the present study has put forth a novel approach, wherein the synergistic action of Strontium (Sr) and MSCs in a single implant may facilitate osteoporotic bone healing. Strontium Hydroxyapatite (SrHA) synthesized by wet precipitation was fabricated into tissue engineered Strontium incorporated Hydroxyapatite (cSrHA) using sheep adipose tissue derived MSCs (ADMSCs). Porosity, radiopacity and cytocompatibility of SrHA scaffolds were found appropriate for orthopaedic applications. cSrHA scaffolds exhibited an in vitro Alkaline Phosphatase activity of 20 μmol pnp/30 min comparable to that of Hydroxyapatite (HA) - control scaffold, proving its osteogenic efficacy. Implantation studies in sheep osteoporotic model depicted enhanced osteogenic ability with mature lamellar bone formation in cSrHA implanted group, compared to bare HA, SrHA and tissue engineered HA implanted groups. Histomorphometry data substantiated improved osteogenesis on par with material resorption, as cSrHA implanted group exhibited highest regeneration ratio of 0.38 ± 0.05. Density histograms from micro CT further signified the enhanced osteointegrative ability of cSrHA implants. Results of the study depicted the therapeutic potential of cSrHA in osteoporotic bone healing and proposes the use of allogenic ADMSCs for fabricating "Off the Shelf Tissue Engineered Products". |
Author | H.K., Varma John, Annie Chandran, Sunitha Shenoy, Sachin J. P. Nair, Renjith Babu S., Suresh |
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Cites_doi | 10.1007/s001980200058 10.1097/01.sap.0000210629.17727.bd 10.1007/s10856-013-5018-y 10.5966/sctm.2015-0369 10.2147/IJN.S101673 10.1016/j.biomaterials.2011.08.009 10.22203/eCM.v013a01 10.1038/jcbfm.2010.220 10.1016/j.actbio.2013.04.035 10.1186/1471-2474-7-67 10.1016/S0020-1383(16)47004-X 10.1016/j.jcyt.2014.07.009 10.1039/c3tb21047b 10.1088/1748-6041/7/3/035005 10.1586/17434440.2.1.87 10.1016/j.biomaterials.2010.01.024 10.1007/s10856-014-5377-z 10.1016/j.biomaterials.2014.05.016 10.1016/j.colsurfb.2016.03.033 10.1016/j.medengphy.2008.01.007 10.1186/s12929-017-0318-z 10.1007/s10856-006-0432-z 10.1002/1097-4636(200011)52:2<270::AID-JBM5>3.0.CO;2-1 10.1089/ten.tea.2009.0472 10.1016/j.colsurfb.2016.07.012 10.1111/j.1365-2559.2012.04333.x 10.15283/ijsc.2011.4.2.99 10.1007/s00198-004-1700-8 10.3390/ijms15034714 10.1016/j.bone.2015.04.040 10.1186/1746-6148-8-169 10.1007/s11914-013-0184-x |
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Keywords | Osteoporosis Osteoporotic sheep Tissue engineering Strontium Hydroxyapatite Mesenchymal stem cells |
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References | Fernandez, Shenoy, Suresh Babu, Varma, John (bib0090) 2012; 7 Ye, Zhang, Xue, Xu, Tan, Liu (bib0175) 2014; 16 Nair, Sindhu, Nair (bib0010) 2016; 1 Lill, Fluegel, Schneider (bib0075) 2002; 13 Hench (bib0110) 2006; 17 Offermanns, Andersen, Riede, Andersen, Almtoft, Sørensen (bib0015) 2016; 11 Sunitha, Harikrishnan, Annie (bib0025) 2017; 7 Grzesiak, Krzysztof, Karol, Joanna (bib0065) 2011; 4 Dudas, Marra, Cooper, Penascino, Mooney, Jiang (bib0140) 2006; 56 Schubert, Xhema, Vériter, Schubert, Behets, Delloye (bib0040) 2011; 32 Meka, Jain, Chatterjee (bib0120) 2016; 1 Kaibuchi, Iwata, Yamato, Okano, Ando (bib0035) 2016 Vériter, André, Aouassar, Poirel, Lafosse, Docquier (bib0045) 2015 Antebi, Pelled, Gazit (bib0030) 2014; 12 Mirsaidi, Genelin, Vetsch, Stanger, Theiss, Lindtner (bib0050) 2014; 35 Nuss, Auer, Boos, von Rechenberg (bib0085) 2006; 7 Lyahyai, Mediano, Ranera, Sanz, Remacha, Bolea (bib0070) 2012; 8 Kilkenny, Browne, Cuthill, Emerson, Altman (bib0055) 2011; 31 Berner, Reichert, Woodruff, Saifzadeh, Morris, Epari (bib0160) 2013; 9 Pei, Li, McConda, Wen, Clovis, Danley (bib0135) 2015; 78 Tao, Bai, He, Liu, Li, Zhou (bib0185) 2016 Zhang, Wei, Chang, Miron, Shi, Yi (bib0115) 2013; 1 El-Ghannam (bib0130) 2005; 2 Zreiqat, Ramaswamy, Wu, Paschalidis, Lu, James (bib0180) 2010; 31 Chang, Stanford, Keller (bib0165) 2000; 52 Yuan, Zhang, Liu, Wei, Qi, Liu (bib0170) 2010; 16 Mohan, Suresh Babu, Varma, John (bib0060) 2013; 24 Pak, Lee, Park, Park, Kang, Lee (bib0155) 2017; 24 Boyd, Rutledge, Randolph, Mutreja, Meenan (bib0100) 2015; 26 Egan, Brennan, Pignolo (bib0095) 2012; 61 Cheung, Miclau, SK-H, Yang, Alt (bib0125) 2016; 47 Wu, Lei, Hu, Wang, Wan, Ma (bib0145) 2008; 30 Gao, Deng, Feng, Mao, Li, Yang (bib0105) 2014; 15 Prins, Schulten, Ten Bruggenkate, Klein-Nulend, Helder (bib0150) 2016; 5 Dreinhöfer, Anderson, Féron, Herrera, Hube, Johnell (bib0005) 2005; 16 Pearce, Richards, Milz, Schneider, Pearce (bib0080) 2007; 13 Chandran, S, Vs, Varma, John (bib0020) 2016 Nair (10.1016/j.colsurfb.2017.12.048_bib0010) 2016; 1 Pak (10.1016/j.colsurfb.2017.12.048_bib0155) 2017; 24 Prins (10.1016/j.colsurfb.2017.12.048_bib0150) 2016; 5 Meka (10.1016/j.colsurfb.2017.12.048_bib0120) 2016; 1 Pei (10.1016/j.colsurfb.2017.12.048_bib0135) 2015; 78 Lill (10.1016/j.colsurfb.2017.12.048_bib0075) 2002; 13 Wu (10.1016/j.colsurfb.2017.12.048_bib0145) 2008; 30 Antebi (10.1016/j.colsurfb.2017.12.048_bib0030) 2014; 12 Egan (10.1016/j.colsurfb.2017.12.048_bib0095) 2012; 61 Ye (10.1016/j.colsurfb.2017.12.048_bib0175) 2014; 16 Yuan (10.1016/j.colsurfb.2017.12.048_bib0170) 2010; 16 Gao (10.1016/j.colsurfb.2017.12.048_bib0105) 2014; 15 Kaibuchi (10.1016/j.colsurfb.2017.12.048_bib0035) 2016 Tao (10.1016/j.colsurfb.2017.12.048_bib0185) 2016 Vériter (10.1016/j.colsurfb.2017.12.048_bib0045) 2015 Lyahyai (10.1016/j.colsurfb.2017.12.048_bib0070) 2012; 8 Dudas (10.1016/j.colsurfb.2017.12.048_bib0140) 2006; 56 Offermanns (10.1016/j.colsurfb.2017.12.048_bib0015) 2016; 11 Berner (10.1016/j.colsurfb.2017.12.048_bib0160) 2013; 9 Fernandez (10.1016/j.colsurfb.2017.12.048_bib0090) 2012; 7 Zhang (10.1016/j.colsurfb.2017.12.048_bib0115) 2013; 1 Grzesiak (10.1016/j.colsurfb.2017.12.048_bib0065) 2011; 4 Dreinhöfer (10.1016/j.colsurfb.2017.12.048_bib0005) 2005; 16 El-Ghannam (10.1016/j.colsurfb.2017.12.048_bib0130) 2005; 2 Boyd (10.1016/j.colsurfb.2017.12.048_bib0100) 2015; 26 Chandran (10.1016/j.colsurfb.2017.12.048_bib0020) 2016 Pearce (10.1016/j.colsurfb.2017.12.048_bib0080) 2007; 13 Kilkenny (10.1016/j.colsurfb.2017.12.048_bib0055) 2011; 31 Nuss (10.1016/j.colsurfb.2017.12.048_bib0085) 2006; 7 Chang (10.1016/j.colsurfb.2017.12.048_bib0165) 2000; 52 Hench (10.1016/j.colsurfb.2017.12.048_bib0110) 2006; 17 Zreiqat (10.1016/j.colsurfb.2017.12.048_bib0180) 2010; 31 Mohan (10.1016/j.colsurfb.2017.12.048_bib0060) 2013; 24 Schubert (10.1016/j.colsurfb.2017.12.048_bib0040) 2011; 32 Sunitha (10.1016/j.colsurfb.2017.12.048_bib0025) 2017; 7 Mirsaidi (10.1016/j.colsurfb.2017.12.048_bib0050) 2014; 35 Cheung (10.1016/j.colsurfb.2017.12.048_bib0125) 2016; 47 |
References_xml | – volume: 30 start-page: 1112 year: 2008 end-page: 1118 ident: bib0145 article-title: Effect of ovariectomy on BMD, micro-architecture and biomechanics of cortical and cancellous bones in a sheep model publication-title: Med. Eng. Phys. contributor: fullname: Ma – year: 2016 ident: bib0020 article-title: Osteogenic efficacy of strontium hydroxyapatite micro-granules in osteoporotic rat model publication-title: J. Biomater. Appl. contributor: fullname: John – volume: 35 start-page: 7326 year: 2014 end-page: 7335 ident: bib0050 article-title: Therapeutic potential of adipose-derived stromal cells in age-related osteoporosis publication-title: Biomaterials contributor: fullname: Lindtner – volume: 24 start-page: 2831 year: 2013 end-page: 2844 ident: bib0060 article-title: In vitro evaluation of bioactive strontium-based ceramic with rabbit adipose-derived stem cells for bone tissue regeneration publication-title: J. Mater. Sci. Mater. Med. contributor: fullname: John – volume: 2 start-page: 87 year: 2005 end-page: 101 ident: bib0130 article-title: Bone reconstruction: from bioceramics to tissue engineering publication-title: Expert Rev. Med. Devices contributor: fullname: El-Ghannam – volume: 9 start-page: 7874 year: 2013 end-page: 7884 ident: bib0160 article-title: Autologous vs. allogenic mesenchymal progenitor cells for the reconstruction of critical sized segmental tibial bone defects in aged sheep publication-title: Acta Biomater. contributor: fullname: Epari – volume: 61 start-page: 1168 year: 2012 end-page: 1173 ident: bib0095 article-title: Bone histomorphometry using free and commonly available software publication-title: Histopathology contributor: fullname: Pignolo – year: 2016 ident: bib0035 article-title: Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model publication-title: Acta Biomater. contributor: fullname: Ando – volume: 5 start-page: 1362 year: 2016 end-page: 1374 ident: bib0150 article-title: Bone regeneration using the freshly isolated autologous stromal vascular fraction of adipose tissue in combination with calcium phosphate ceramics publication-title: Stem Cells Transl. Med. contributor: fullname: Helder – volume: 26 start-page: 65 year: 2015 ident: bib0100 article-title: The deposition of strontium-substituted hydroxyapatite coatings publication-title: J. Mater. Sci. Mater. Med. contributor: fullname: Meenan – volume: 1 start-page: 5711 year: 2013 end-page: 5722 ident: bib0115 article-title: Strontium-incorporated mesoporous bioactive glass scaffolds stimulating in vitro proliferation and differentiation of bone marrow stromal cells and in vivo regeneration of osteoporotic bone defects publication-title: J. Mater. Chem. B contributor: fullname: Yi – volume: 78 start-page: 1 year: 2015 end-page: 10 ident: bib0135 article-title: A comparison of tissue engineering based repair of calvarial defects using adipose stem cells from normal and osteoporotic rats publication-title: Bone contributor: fullname: Danley – volume: 56 start-page: 543 year: 2006 end-page: 548 ident: bib0140 article-title: The osteogenic potential of adipose-derived stem cells for the repair of rabbit calvarial defects publication-title: Ann. Plast. Surg. contributor: fullname: Jiang – volume: 16 start-page: 1643 year: 2014 end-page: 1655 ident: bib0175 article-title: Adipose-derived stem cells alleviate osteoporosis by enhancing osteogenesis and inhibiting adipogenesis in a rabbit model publication-title: Cytotherapy contributor: fullname: Liu – year: 2015 ident: bib0045 article-title: Human adipose-Derived mesenchymal stem cells in cell therapy: safety and feasibility in different hospital exemption clinical applications publication-title: PLoS One contributor: fullname: Docquier – volume: 13 start-page: 1 year: 2007 end-page: 10 ident: bib0080 article-title: Animal models for implant biomaterial research in bone: a review publication-title: Eur. Cell Mater. contributor: fullname: Pearce – volume: 12 start-page: 41 year: 2014 end-page: 47 ident: bib0030 article-title: Stem cell therapy for osteoporosis publication-title: Curr. Osteoporos Rep. contributor: fullname: Gazit – volume: 7 start-page: 035005 year: 2012 ident: bib0090 article-title: Short-term studies using ceramic scaffolds in lapine model for osteochondral defect amelioration publication-title: Biomed. Mater. Bristol. Engl. contributor: fullname: John – volume: 31 start-page: 3175 year: 2010 end-page: 3184 ident: bib0180 article-title: The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering publication-title: Biomaterials contributor: fullname: James – volume: 47 start-page: S21 year: 2016 end-page: 26 ident: bib0125 article-title: Fracture healing in osteoporotic bone publication-title: Injury contributor: fullname: Alt – volume: 32 start-page: 8880 year: 2011 end-page: 8891 ident: bib0040 article-title: The enhanced performance of bone allografts using osteogenic-differentiated adipose-derived mesenchymal stem cells publication-title: Biomaterials contributor: fullname: Delloye – volume: 16 start-page: S44 year: 2005 end-page: S53 ident: bib0005 article-title: Multinational survey of osteoporotic fracture management publication-title: Osteoporos Int. contributor: fullname: Johnell – volume: 8 start-page: 169 year: 2012 ident: bib0070 article-title: Isolation and characterization of ovine mesenchymal stem cells derived from peripheral blood publication-title: BMC Vet. Res. contributor: fullname: Bolea – volume: 1 start-page: 649 year: 2016 end-page: 656 ident: bib0120 article-title: Strontium eluting nanofibers augment stem cell osteogenesis for bone tissue regeneration publication-title: Colloids Surf. B Biointerfaces contributor: fullname: Chatterjee – volume: 15 start-page: 4714 year: 2014 end-page: 4732 ident: bib0105 article-title: Current progress in bioactive ceramic scaffolds for bone repair and regeneration publication-title: Int. J. Mol. Sci. contributor: fullname: Yang – volume: 16 start-page: 1385 year: 2010 end-page: 1394 ident: bib0170 article-title: Repair of canine mandibular bone defects with bone marrow stromal cells and coral publication-title: Tissue Eng. Part A contributor: fullname: Liu – volume: 1 start-page: 423 year: 2016 end-page: 430 ident: bib0010 article-title: Polycaprolactone-laponite composite scaffold releasing strontium ranelate for bone tissue engineering applications publication-title: Colloids Surf. B Biointerfaces contributor: fullname: Nair – volume: 7 start-page: 67 year: 2006 ident: bib0085 article-title: An animal model in sheep for biocompatibility testing of biomaterials in cancellous bones publication-title: BMC Musculoskelet Disord. contributor: fullname: von Rechenberg – volume: 17 start-page: 967 year: 2006 end-page: 978 ident: bib0110 article-title: The story of bioglass publication-title: J. Mater. Sci. Mater. Med. contributor: fullname: Hench – volume: 7 start-page: 36 year: 2017 end-page: 43 ident: bib0025 article-title: Ovariectomised and long term induced (OLI) rat model for preclinical assessment of osteoporotic therapeutics publication-title: J. Drug Deliv. Ther. contributor: fullname: Annie – volume: 52 start-page: 270 year: 2000 end-page: 278 ident: bib0165 article-title: Calcium and phosphate supplementation promotes bone cell mineralization: implications for hydroxyapatite (HA)-enhanced bone formation publication-title: J. Biomed. Mater. Res. contributor: fullname: Keller – volume: 11 start-page: 2431 year: 2016 end-page: 2442 ident: bib0015 article-title: Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats publication-title: Int. J. Nanomed. contributor: fullname: Sørensen – year: 2016 ident: bib0185 article-title: A comparative study of strontium-substituted hydroxyapatite coating on implant’s osseointegration for osteopenic rats publication-title: Med. Biol. Eng. Comput. contributor: fullname: Zhou – volume: 31 start-page: 991 year: 2011 end-page: 993 ident: bib0055 article-title: National centre for the replacement, refinement and reduction of amimals in research. Animal research: reporting in vivo experiments–the ARRIVE guidelines publication-title: J. Cereb. Blood Flow Metab. contributor: fullname: Altman – volume: 4 start-page: 99 year: 2011 end-page: 104 ident: bib0065 article-title: Isolation and morphological characterisation of ovine adipose-derived mesenchymal stem cells in culture publication-title: Int. J. Stem Cells contributor: fullname: Joanna – volume: 24 start-page: 9 year: 2017 ident: bib0155 article-title: Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications publication-title: J. Biomed. Sci. contributor: fullname: Lee – volume: 13 start-page: 480 year: 2002 end-page: 486 ident: bib0075 article-title: Effect of ovariectomy, malnutrition and glucocorticoid application on bone properties in sheep: a pilot study publication-title: Osteoporos Int. contributor: fullname: Schneider – volume: 13 start-page: 480 issue: 6 year: 2002 ident: 10.1016/j.colsurfb.2017.12.048_bib0075 article-title: Effect of ovariectomy, malnutrition and glucocorticoid application on bone properties in sheep: a pilot study publication-title: Osteoporos Int. doi: 10.1007/s001980200058 contributor: fullname: Lill – volume: 56 start-page: 543 issue: May (5) year: 2006 ident: 10.1016/j.colsurfb.2017.12.048_bib0140 article-title: The osteogenic potential of adipose-derived stem cells for the repair of rabbit calvarial defects publication-title: Ann. Plast. Surg. doi: 10.1097/01.sap.0000210629.17727.bd contributor: fullname: Dudas – volume: 24 start-page: 2831 issue: December (12) year: 2013 ident: 10.1016/j.colsurfb.2017.12.048_bib0060 article-title: In vitro evaluation of bioactive strontium-based ceramic with rabbit adipose-derived stem cells for bone tissue regeneration publication-title: J. Mater. Sci. Mater. Med. doi: 10.1007/s10856-013-5018-y contributor: fullname: Mohan – volume: 5 start-page: 1362 issue: 10 year: 2016 ident: 10.1016/j.colsurfb.2017.12.048_bib0150 article-title: Bone regeneration using the freshly isolated autologous stromal vascular fraction of adipose tissue in combination with calcium phosphate ceramics publication-title: Stem Cells Transl. Med. doi: 10.5966/sctm.2015-0369 contributor: fullname: Prins – volume: 11 start-page: 2431 year: 2016 ident: 10.1016/j.colsurfb.2017.12.048_bib0015 article-title: Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S101673 contributor: fullname: Offermanns – volume: 32 start-page: 8880 issue: December (34) year: 2011 ident: 10.1016/j.colsurfb.2017.12.048_bib0040 article-title: The enhanced performance of bone allografts using osteogenic-differentiated adipose-derived mesenchymal stem cells publication-title: Biomaterials doi: 10.1016/j.biomaterials.2011.08.009 contributor: fullname: Schubert – issue: April year: 2016 ident: 10.1016/j.colsurfb.2017.12.048_bib0185 article-title: A comparative study of strontium-substituted hydroxyapatite coating on implant’s osseointegration for osteopenic rats publication-title: Med. Biol. Eng. Comput. contributor: fullname: Tao – volume: 13 start-page: 1 year: 2007 ident: 10.1016/j.colsurfb.2017.12.048_bib0080 article-title: Animal models for implant biomaterial research in bone: a review publication-title: Eur. Cell Mater. doi: 10.22203/eCM.v013a01 contributor: fullname: Pearce – volume: 31 start-page: 991 issue: April (4) year: 2011 ident: 10.1016/j.colsurfb.2017.12.048_bib0055 article-title: National centre for the replacement, refinement and reduction of amimals in research. Animal research: reporting in vivo experiments–the ARRIVE guidelines publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2010.220 contributor: fullname: Kilkenny – volume: 9 start-page: 7874 issue: August (8) year: 2013 ident: 10.1016/j.colsurfb.2017.12.048_bib0160 article-title: Autologous vs. allogenic mesenchymal progenitor cells for the reconstruction of critical sized segmental tibial bone defects in aged sheep publication-title: Acta Biomater. doi: 10.1016/j.actbio.2013.04.035 contributor: fullname: Berner – volume: 7 start-page: 67 year: 2006 ident: 10.1016/j.colsurfb.2017.12.048_bib0085 article-title: An animal model in sheep for biocompatibility testing of biomaterials in cancellous bones publication-title: BMC Musculoskelet Disord. doi: 10.1186/1471-2474-7-67 contributor: fullname: Nuss – volume: 47 start-page: S21 issue: June (Suppl. 2) year: 2016 ident: 10.1016/j.colsurfb.2017.12.048_bib0125 article-title: Fracture healing in osteoporotic bone publication-title: Injury doi: 10.1016/S0020-1383(16)47004-X contributor: fullname: Cheung – volume: 16 start-page: 1643 issue: December (12) year: 2014 ident: 10.1016/j.colsurfb.2017.12.048_bib0175 article-title: Adipose-derived stem cells alleviate osteoporosis by enhancing osteogenesis and inhibiting adipogenesis in a rabbit model publication-title: Cytotherapy doi: 10.1016/j.jcyt.2014.07.009 contributor: fullname: Ye – volume: 1 start-page: 5711 issue: October (41) year: 2013 ident: 10.1016/j.colsurfb.2017.12.048_bib0115 article-title: Strontium-incorporated mesoporous bioactive glass scaffolds stimulating in vitro proliferation and differentiation of bone marrow stromal cells and in vivo regeneration of osteoporotic bone defects publication-title: J. Mater. Chem. B doi: 10.1039/c3tb21047b contributor: fullname: Zhang – issue: May year: 2016 ident: 10.1016/j.colsurfb.2017.12.048_bib0020 article-title: Osteogenic efficacy of strontium hydroxyapatite micro-granules in osteoporotic rat model publication-title: J. Biomater. Appl. contributor: fullname: Chandran – volume: 7 start-page: 035005 issue: June (3) year: 2012 ident: 10.1016/j.colsurfb.2017.12.048_bib0090 article-title: Short-term studies using ceramic scaffolds in lapine model for osteochondral defect amelioration publication-title: Biomed. Mater. Bristol. Engl. doi: 10.1088/1748-6041/7/3/035005 contributor: fullname: Fernandez – volume: 2 start-page: 87 issue: January (1) year: 2005 ident: 10.1016/j.colsurfb.2017.12.048_bib0130 article-title: Bone reconstruction: from bioceramics to tissue engineering publication-title: Expert Rev. Med. Devices doi: 10.1586/17434440.2.1.87 contributor: fullname: El-Ghannam – volume: 31 start-page: 3175 issue: April (12) year: 2010 ident: 10.1016/j.colsurfb.2017.12.048_bib0180 article-title: The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering publication-title: Biomaterials doi: 10.1016/j.biomaterials.2010.01.024 contributor: fullname: Zreiqat – volume: 26 start-page: 65 issue: February (2) year: 2015 ident: 10.1016/j.colsurfb.2017.12.048_bib0100 article-title: The deposition of strontium-substituted hydroxyapatite coatings publication-title: J. Mater. Sci. Mater. Med. doi: 10.1007/s10856-014-5377-z contributor: fullname: Boyd – volume: 35 start-page: 7326 issue: August (26) year: 2014 ident: 10.1016/j.colsurfb.2017.12.048_bib0050 article-title: Therapeutic potential of adipose-derived stromal cells in age-related osteoporosis publication-title: Biomaterials doi: 10.1016/j.biomaterials.2014.05.016 contributor: fullname: Mirsaidi – volume: 1 start-page: 423 issue: July (143) year: 2016 ident: 10.1016/j.colsurfb.2017.12.048_bib0010 article-title: Polycaprolactone-laponite composite scaffold releasing strontium ranelate for bone tissue engineering applications publication-title: Colloids Surf. B Biointerfaces doi: 10.1016/j.colsurfb.2016.03.033 contributor: fullname: Nair – issue: October year: 2015 ident: 10.1016/j.colsurfb.2017.12.048_bib0045 article-title: Human adipose-Derived mesenchymal stem cells in cell therapy: safety and feasibility in different hospital exemption clinical applications publication-title: PLoS One contributor: fullname: Vériter – volume: 30 start-page: 1112 issue: November (9) year: 2008 ident: 10.1016/j.colsurfb.2017.12.048_bib0145 article-title: Effect of ovariectomy on BMD, micro-architecture and biomechanics of cortical and cancellous bones in a sheep model publication-title: Med. Eng. Phys. doi: 10.1016/j.medengphy.2008.01.007 contributor: fullname: Wu – volume: 24 start-page: 9 issue: January (1) year: 2017 ident: 10.1016/j.colsurfb.2017.12.048_bib0155 article-title: Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications publication-title: J. Biomed. Sci. doi: 10.1186/s12929-017-0318-z contributor: fullname: Pak – volume: 17 start-page: 967 issue: November (11) year: 2006 ident: 10.1016/j.colsurfb.2017.12.048_bib0110 article-title: The story of bioglass publication-title: J. Mater. Sci. Mater. Med. doi: 10.1007/s10856-006-0432-z contributor: fullname: Hench – volume: 52 start-page: 270 issue: November (2) year: 2000 ident: 10.1016/j.colsurfb.2017.12.048_bib0165 article-title: Calcium and phosphate supplementation promotes bone cell mineralization: implications for hydroxyapatite (HA)-enhanced bone formation publication-title: J. Biomed. Mater. Res. doi: 10.1002/1097-4636(200011)52:2<270::AID-JBM5>3.0.CO;2-1 contributor: fullname: Chang – volume: 16 start-page: 1385 issue: April (4) year: 2010 ident: 10.1016/j.colsurfb.2017.12.048_bib0170 article-title: Repair of canine mandibular bone defects with bone marrow stromal cells and coral publication-title: Tissue Eng. Part A doi: 10.1089/ten.tea.2009.0472 contributor: fullname: Yuan – volume: 1 start-page: 649 issue: October (146 year: 2016 ident: 10.1016/j.colsurfb.2017.12.048_bib0120 article-title: Strontium eluting nanofibers augment stem cell osteogenesis for bone tissue regeneration publication-title: Colloids Surf. B Biointerfaces doi: 10.1016/j.colsurfb.2016.07.012 contributor: fullname: Meka – volume: 61 start-page: 1168 issue: December (6) year: 2012 ident: 10.1016/j.colsurfb.2017.12.048_bib0095 article-title: Bone histomorphometry using free and commonly available software publication-title: Histopathology doi: 10.1111/j.1365-2559.2012.04333.x contributor: fullname: Egan – volume: 4 start-page: 99 issue: November (2) year: 2011 ident: 10.1016/j.colsurfb.2017.12.048_bib0065 article-title: Isolation and morphological characterisation of ovine adipose-derived mesenchymal stem cells in culture publication-title: Int. J. Stem Cells doi: 10.15283/ijsc.2011.4.2.99 contributor: fullname: Grzesiak – volume: 16 start-page: S44 issue: March (Suppl. 2) year: 2005 ident: 10.1016/j.colsurfb.2017.12.048_bib0005 article-title: Multinational survey of osteoporotic fracture management publication-title: Osteoporos Int. doi: 10.1007/s00198-004-1700-8 contributor: fullname: Dreinhöfer – issue: June year: 2016 ident: 10.1016/j.colsurfb.2017.12.048_bib0035 article-title: Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model publication-title: Acta Biomater. contributor: fullname: Kaibuchi – volume: 15 start-page: 4714 issue: March (3) year: 2014 ident: 10.1016/j.colsurfb.2017.12.048_bib0105 article-title: Current progress in bioactive ceramic scaffolds for bone repair and regeneration publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms15034714 contributor: fullname: Gao – volume: 78 start-page: 1 issue: September year: 2015 ident: 10.1016/j.colsurfb.2017.12.048_bib0135 article-title: A comparison of tissue engineering based repair of calvarial defects using adipose stem cells from normal and osteoporotic rats publication-title: Bone doi: 10.1016/j.bone.2015.04.040 contributor: fullname: Pei – volume: 7 start-page: 36 issue: March (2) year: 2017 ident: 10.1016/j.colsurfb.2017.12.048_bib0025 article-title: Ovariectomised and long term induced (OLI) rat model for preclinical assessment of osteoporotic therapeutics publication-title: J. Drug Deliv. Ther. contributor: fullname: Sunitha – volume: 8 start-page: 169 issue: September year: 2012 ident: 10.1016/j.colsurfb.2017.12.048_bib0070 article-title: Isolation and characterization of ovine mesenchymal stem cells derived from peripheral blood publication-title: BMC Vet. Res. doi: 10.1186/1746-6148-8-169 contributor: fullname: Lyahyai – volume: 12 start-page: 41 issue: March (1) year: 2014 ident: 10.1016/j.colsurfb.2017.12.048_bib0030 article-title: Stem cell therapy for osteoporosis publication-title: Curr. Osteoporos Rep. doi: 10.1007/s11914-013-0184-x contributor: fullname: Antebi |
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Snippet | Tissue engineered SrHA (cSrHA) scaffolds fabricated by seeding Adipose Derived Mesenchymal Stem Cells (ADMSCs) on Strontium incorporated Hydroxyapatite... Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies... |
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SubjectTerms | Mesenchymal stem cells Osteoporosis Osteoporotic sheep Strontium Hydroxyapatite Tissue engineering |
Title | Strontium Hydroxyapatite scaffolds engineered with stem cells aid osteointegration and osteogenesis in osteoporotic sheep model |
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