Effects of essential oil from Croton tiglium L. on intestinal transit in mice
Croton tiglium ( Croton tiglium L., Euphorbiaceae) is widely used as a herb for treatment of gastrointestinal disturbances. Previous studies established its purgative and inflammational properties. The present study aimed to investigate the effects of Croton tiglium oil (CO) on intestinal transit in...
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| Published in | Journal of ethnopharmacology Vol. 117; no. 1; pp. 102 - 107 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier Ireland Ltd
17.04.2008
Amsterdam; New York: Elsevier Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Croton tiglium (
Croton tiglium L., Euphorbiaceae) is widely used as a herb for treatment of gastrointestinal disturbances. Previous studies established its purgative and inflammational properties. The present study aimed to investigate the effects of
Croton tiglium oil (CO) on intestinal transit in mice.
Gastrointestinal transit in mice and contractile characteristics of isolated intestinal strips from mice were evaluated. Intestinal inflammation was confirmed by histological examination.
Low dose of CO increased the gastrointestinal transit of charcoal and barium meal as well as the production of fecal pellets in mice. In contrast, high dose exerted inhibitory effects. For normal colonic circular strips, both high and low dose of CO inhibited the contractile frequency. Low doses (0–20
μg/ml) of CO enhanced the phasic contractions, while high doses (>40
μg/ml) reduced them. Colonic longitudinal strips in CO-treated mice were less sensitive to electrical field stimulation than those in control mice. The contraction of colonic longitudinal, colonic and jejunal circular strips in CO-treated mice was more sensitive to atropine than that in control mice.
CO might modulate gastrointestinal motility and induce intestinal inflammation related to immunological milieu and motor activity. Our findings may highlight the ethno-medical uses of
Croton tiglium on intestinal disorders. |
|---|---|
| AbstractList | Aim of the Study: Croton tiglium (Croton tiglium L., Euphorbiaceae) is widely used as a herb for treatment of gastrointestinal disturbances. Previous studies established its purgative and inflammational properties. The present study aimed to investigate the effects of Croton tiglium oil (CO) on intestinal transit in mice. Materials and Methods: Gastrointestinal transit in mice and contractile characteristics of isolated intestinal strips from mice were evaluated. Intestinal inflammation was confirmed by histological examination. Results: Low dose of CO increased the gastrointestinal transit of charcoal and barium meal as well as the production of fecal pellets in mice. In contrast, high dose exerted inhibitory effects. For normal colonic circular strips, both high and low dose of CO inhibited the contractile frequency. Low doses (0-20μg/ml) of CO enhanced the phasic contractions, while high doses (>40μg/ml) reduced them. Colonic longitudinal strips in CO-treated mice were less sensitive to electrical field stimulation than those in control mice. The contraction of colonic longitudinal, colonic and jejunal circular strips in CO-treated mice was more sensitive to atropine than that in control mice. Conclusions: CO might modulate gastrointestinal motility and induce intestinal inflammation related to immunological milieu and motor activity. Our findings may highlight the ethno-medical uses of Croton tiglium on intestinal disorders. AIM OF THE STUDYCroton tiglium (Croton tiglium L., Euphorbiaceae) is widely used as a herb for treatment of gastrointestinal disturbances. Previous studies established its purgative and inflammational properties. The present study aimed to investigate the effects of Croton tiglium oil (CO) on intestinal transit in mice.MATERIALS AND METHODSGastrointestinal transit in mice and contractile characteristics of isolated intestinal strips from mice were evaluated. Intestinal inflammation was confirmed by histological examination.RESULTSLow dose of CO increased the gastrointestinal transit of charcoal and barium meal as well as the production of fecal pellets in mice. In contrast, high dose exerted inhibitory effects. For normal colonic circular strips, both high and low dose of CO inhibited the contractile frequency. Low doses (0-20 microg/ml) of CO enhanced the phasic contractions, while high doses (>40 microg/ml) reduced them. Colonic longitudinal strips in CO-treated mice were less sensitive to electrical field stimulation than those in control mice. The contraction of colonic longitudinal, colonic and jejunal circular strips in CO-treated mice was more sensitive to atropine than that in control mice.CONCLUSIONSCO might modulate gastrointestinal motility and induce intestinal inflammation related to immunological milieu and motor activity. Our findings may highlight the ethno-medical uses of Croton tiglium on intestinal disorders. Croton tiglium ( Croton tiglium L., Euphorbiaceae) is widely used as a herb for treatment of gastrointestinal disturbances. Previous studies established its purgative and inflammational properties. The present study aimed to investigate the effects of Croton tiglium oil (CO) on intestinal transit in mice. Gastrointestinal transit in mice and contractile characteristics of isolated intestinal strips from mice were evaluated. Intestinal inflammation was confirmed by histological examination. Low dose of CO increased the gastrointestinal transit of charcoal and barium meal as well as the production of fecal pellets in mice. In contrast, high dose exerted inhibitory effects. For normal colonic circular strips, both high and low dose of CO inhibited the contractile frequency. Low doses (0–20 μg/ml) of CO enhanced the phasic contractions, while high doses (>40 μg/ml) reduced them. Colonic longitudinal strips in CO-treated mice were less sensitive to electrical field stimulation than those in control mice. The contraction of colonic longitudinal, colonic and jejunal circular strips in CO-treated mice was more sensitive to atropine than that in control mice. CO might modulate gastrointestinal motility and induce intestinal inflammation related to immunological milieu and motor activity. Our findings may highlight the ethno-medical uses of Croton tiglium on intestinal disorders. Croton tiglium (Croton tiglium L., Euphorbiaceae) is widely used as a herb for treatment of gastrointestinal disturbances. Previous studies established its purgative and inflammational properties. The present study aimed to investigate the effects of Croton tiglium oil (CO) on intestinal transit in mice. Gastrointestinal transit in mice and contractile characteristics of isolated intestinal strips from mice were evaluated. Intestinal inflammation was confirmed by histological examination. Low dose of CO increased the gastrointestinal transit of charcoal and barium meal as well as the production of fecal pellets in mice. In contrast, high dose exerted inhibitory effects. For normal colonic circular strips, both high and low dose of CO inhibited the contractile frequency. Low doses (0-20 microg/ml) of CO enhanced the phasic contractions, while high doses (>40 microg/ml) reduced them. Colonic longitudinal strips in CO-treated mice were less sensitive to electrical field stimulation than those in control mice. The contraction of colonic longitudinal, colonic and jejunal circular strips in CO-treated mice was more sensitive to atropine than that in control mice. CO might modulate gastrointestinal motility and induce intestinal inflammation related to immunological milieu and motor activity. Our findings may highlight the ethno-medical uses of Croton tiglium on intestinal disorders. |
| Author | Lan, Mei Zhang, FaMing Liu, ZhenXiong Wang, Xin Bai, FeiHu Fan, DaiMing Feng, HanZhong Yu, Zhi Bin Shi, YongQuan Lu, YuanYuan Zhai, HuiHong Jin, JianPing |
| Author_xml | – sequence: 1 givenname: Xin surname: Wang fullname: Wang, Xin organization: State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Changle West Road, Xi’an 710032, China – sequence: 2 givenname: FaMing surname: Zhang fullname: Zhang, FaMing organization: State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Changle West Road, Xi’an 710032, China – sequence: 3 givenname: ZhenXiong surname: Liu fullname: Liu, ZhenXiong organization: State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Changle West Road, Xi’an 710032, China – sequence: 4 givenname: HanZhong surname: Feng fullname: Feng, HanZhong organization: Department of Aerospace Physiology, Fourth Military Medical University, Xi’an 710032, China – sequence: 5 givenname: Zhi Bin surname: Yu fullname: Yu, Zhi Bin organization: Department of Aerospace Physiology, Fourth Military Medical University, Xi’an 710032, China – sequence: 6 givenname: YuanYuan surname: Lu fullname: Lu, YuanYuan organization: State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Changle West Road, Xi’an 710032, China – sequence: 7 givenname: HuiHong surname: Zhai fullname: Zhai, HuiHong organization: State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Changle West Road, Xi’an 710032, China – sequence: 8 givenname: FeiHu surname: Bai fullname: Bai, FeiHu organization: State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Changle West Road, Xi’an 710032, China – sequence: 9 givenname: YongQuan surname: Shi fullname: Shi, YongQuan organization: State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Changle West Road, Xi’an 710032, China – sequence: 10 givenname: Mei surname: Lan fullname: Lan, Mei organization: State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Changle West Road, Xi’an 710032, China – sequence: 11 givenname: JianPing surname: Jin fullname: Jin, JianPing organization: Section of Molecular Cardiology, Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA – sequence: 12 givenname: DaiMing surname: Fan fullname: Fan, DaiMing email: fandaim@fmmu.edu.cn organization: State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Changle West Road, Xi’an 710032, China |
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| Cites_doi | 10.1540/jsmr.40.237 10.1038/sj.bjp.0706710 10.1016/j.gassur.2004.06.004 10.1152/ajpgi.00408.2003 10.1124/jpet.105.091991 10.1152/ajpgi.00060.2006 10.1152/ajpgi.00255.2004 10.1016/S0304-3940(98)00866-0 10.1248/bpb.27.162 10.3748/wjg.v8.i1.162 10.3748/wjg.v8.i1.103 10.1016/j.jep.2006.10.011 10.1016/S0304-3940(02)00251-3 10.1152/ajpgi.2001.280.4.G546 10.1016/j.lfs.2005.05.032 |
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| Keywords | Croton tiglium L Euphorbiaceae Traditional medicine Gastrointestinal motility Muscarinic receptor Inflammation Motility Gastrointestinal Medicinal plant Cholinergic receptor Folk medicine Dicotyledones Angiospermae Essential oil Stomach Digestive system Pharmacognosy Rodentia Gut Digestion Digestive transit Vertebrata Mammalia Mouse Animal Plant origin Spermatophyta |
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| Snippet | Croton tiglium (
Croton tiglium L., Euphorbiaceae) is widely used as a herb for treatment of gastrointestinal disturbances. Previous studies established its... Aim of the Study: Croton tiglium (Croton tiglium L., Euphorbiaceae) is widely used as a herb for treatment of gastrointestinal disturbances. Previous studies... Croton tiglium (Croton tiglium L., Euphorbiaceae) is widely used as a herb for treatment of gastrointestinal disturbances. Previous studies established its... AIM OF THE STUDYCroton tiglium (Croton tiglium L., Euphorbiaceae) is widely used as a herb for treatment of gastrointestinal disturbances. Previous studies... |
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| SubjectTerms | animal models Animals Atropine - pharmacology Biological and medical sciences colon Croton - chemistry Croton tiglium Croton tiglium L dosage dose response essential oils Euphorbiaceae feces Female Gastrointestinal motility gastrointestinal transit Gastrointestinal Transit - drug effects General pharmacology In Vitro Techniques Inflammation intestines Male Medical sciences medicinal plants medicinal properties Mice Mice, Inbred BALB C Muscarinic receptor muscle contraction Muscle Contraction - drug effects Oils, Volatile - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments purgative properties smooth muscle tissue culture Traditional medicine |
| Title | Effects of essential oil from Croton tiglium L. on intestinal transit in mice |
| URI | https://dx.doi.org/10.1016/j.jep.2008.01.023 https://www.ncbi.nlm.nih.gov/pubmed/18329205 https://search.proquest.com/docview/70443868 |
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