Production of advanced solid dispersions for enhanced bioavailability of itraconazole using KinetiSol Dispersing

• Published in: Drug development and industrial pharmacy Vol. 36; no. 9; p. 1064
• Main Authors: DiNunzio, James C, Hughey, Justin R, Brough, Chris, Miller, Dave A, Williams, 3rd, Robert O, McGinity, James W
• Format: Journal Article
• Language: English
• Published: England 01.09.2010
• Subjects: Administration, Oral; Animals; Antifungal Agents - analysis; Antifungal Agents - chemistry; Antifungal Agents - pharmacokinetics; Biological Availability; Dosage Forms; Drug Compounding; Drug Stability; Excipients; Hydrophobic and Hydrophilic Interactions; Itraconazole - analysis; Itraconazole - chemistry; Itraconazole - pharmacokinetics; Pharmaceutic Aids; Polymers - chemistry; Rats; Rats, Sprague-Dawley; Solubility

To investigate the ability of KinetiSol Dispersing to prepare amorphous solid dispersions of itraconazole using concentration-enhancing polymers. Concentration-enhancing nature of several cellulosic polymers (HPMC, hypromellose acetate succinate) was studied using a modified in vitro dissolution tes...