Asthmatic subjects with allergy have elevated levels of IgE+ B cells in the airways

• Published in: Journal of allergy and clinical immunology Vol. 140; no. 2; pp. 590 - 593.e9
• Main Authors: Oliveria, John-Paul, Salter, Brittany M., Phan, Stephanie, Obminski, Caitlin D., Munoz, Caroline E., Smith, Steven G., Scime, Tara, Watson, Rick M., Sehmi, Roma, Gauvreau, Gail M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2017; Elsevier Limited
• Subjects: Allergens; Allergens - immunology; Allergies; Allergy and Immunology; Asthma; Asthma - complications; Asthma - diagnosis; Asthma - immunology; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Biomarkers; BLyS protein; Cell Membrane - immunology; Cell Membrane - metabolism; Dander; Humans; Hypersensitivity - complications; Hypersensitivity - diagnosis; Hypersensitivity - immunology; Immunoglobulin E; Immunoglobulin E - immunology; Immunoglobulin E - metabolism; Immunoglobulin G; Immunoglobulins; Inflammation; Leukocytes (basophilic); Leukocytes (eosinophilic); Lymphocyte Count; Lymphocyte receptors; Lymphocytes; Lymphocytes B; Mast cells; Methacholine; Respiratory System - immunology; Respiratory System - metabolism; Skin tests; Sputum; Sputum - immunology; Sputum - metabolism; T cell receptors; Ontario Canada; Canada

To The Editor: Allergic asthma is an IgE-mediated disease whereby inhaled allergens cross-link membrane-bound IgE on the surfaces of mast cells and basophils, inducing the activation and release of proinflammatory mediators, and driving type-2 inflammation and the manifestation of clinical symptoms....