COVID-19 mRNA-1273 vaccination induced mast cell activation with strongly elevated Th2 cytokines in a systemic mastocytosis patient

• Published in: Inflammation research Vol. 74; no. 1; p. 71
• Main Authors: Weiss-Tessbach, Matthias, Haider, Teresa, Gowran, Aoife, Schubert, Lorenz, Mühlbacher, Jakob, Brankovic, Jelena, Wahrmann, Markus, Jilma, Bernd, Boehm, Thomas
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2025; Springer Nature B.V
• Subjects: Allergology; Amino acids; Biomedical and Life Sciences; Biomedicine; Cell activation; Chemokines; COVID-19; CXCL10 protein; Cytokines; Dermatology; Granulocyte-macrophage colony-stimulating factor; Immunization; Immunology; Interleukin 1 receptor antagonist; Interleukin 1 receptors; Interleukin 6; Interleukin 6 receptors; Lipids; Lymphocytes T; Mastocytosis; Metabolism; Metabolomics; mRNA; Neurology; Original Research Paper; Pharmacology/Toxicology; Receptors; Rheumatology; Severe acute respiratory syndrome coronavirus 2; Tryptase; Vaccines; Viral diseases; Histamine; SARS-Cov-2; Th; Tocilizumab; biased cytokines; mRNA-1273 vaccination; Systemic mastocytosis

Objective and design SARS-CoV-2 vaccines are recommended for mastocytosis patients. We describe clinical symptoms, chemokine, cytokine, metabolomic and lipidomic derangements in a systemic mastocytosis patient following mRNA-1273 booster vaccination. Methods Twenty-eight chemokines and cytokines, 41...