Brain tumors: detection with C-11 choline PET
To evaluate the effectiveness of positron emission tomography (PET) with carbon-11 choline in brain tumor imaging. A rat glioma cell line (C6) was incubated with C-14 choline; the time course of uptake and metabolism was determined in vitro. C-11 choline was injected intravenously in tumor-bearing r...
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Published in | Radiology Vol. 202; no. 2; p. 497 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.02.1997
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Subjects | |
Online Access | Get more information |
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Summary: | To evaluate the effectiveness of positron emission tomography (PET) with carbon-11 choline in brain tumor imaging.
A rat glioma cell line (C6) was incubated with C-14 choline; the time course of uptake and metabolism was determined in vitro. C-11 choline was injected intravenously in tumor-bearing rats; the time course of distribution in organs was determined. C-11 choline also was injected intravenously in 20 patients (aged 6-86 years) with brain tumors and two volunteers (aged 38 and 58 years); distribution of the tracer in the brain was determined. Regional cerebral blood flow was measured by using oxygen-15 water on the same day.
C-14 choline was metabolized to phosphoryl choline in glioma cells. The uptake of C-11 choline by glioblastoma cells was three to four times higher than that in the rat brain. All brain tumors took up more C-11 choline than did normal brain; thus, brain tumors that were not treated, as well as those that were treated with surgery or radiation therapy, were depicted. The tumor-normal brain uptake ratio of C-11 choline in brain tumor did not correlate with the O-15 water regional blood flow in the corresponding area.
C-11 choline PET can depict brain tumors effectively. This method was clinically useful in patients who had undergone surgery. |
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ISSN: | 0033-8419 1527-1315 |
DOI: | 10.1148/radiology.202.2.9015080 |