Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas

• Published in: Breast cancer research : BCR Vol. 21; no. 1; p. 3
• Main Authors: Hoffman, Joshua, Fejerman, Laura, Hu, Donglei, Huntsman, Scott, Li, Min, John, Esther M, Torres-Mejia, Gabriela, Kushi, Larry, Ding, Yuan Chun, Weitzel, Jeffrey, Neuhausen, Susan L, Lott, Paul, Echeverry, Magdalena, Carvajal-Carmona, Luis, Burchard, Esteban, Eng, Celeste, Long, Jirong, Zheng, Wei, Olopade, Olufunmilayo, Huo, Dezheng, Haiman, Christopher, Ziv, Elad
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.01.2019; BioMed Central; BMC
• Subjects: Adult; Aged; Asians; Breast; Breast cancer; Breast Neoplasms - genetics; Cancer research; Case-Control Studies; Chromosome 6; Chromosome Mapping; Chromosomes, Human, Pair 6 - genetics; Datasets as Topic; Disease susceptibility; Female; Fine mapping; Gene mapping; Genetic aspects; Genetic diversity; Genetic Loci - genetics; Genetic polymorphisms; Genetic Predisposition to Disease; Genetic research; Genome wide association study; Genomes; Genomics; Health aspects; Health risk assessment; Hispanic American women; Hispanic Americans; Hispanic Americans - genetics; Hispanic/Latino populations; Hormone replacement therapy; Humans; Linkage disequilibrium; Mexican American literature; Middle Aged; Novels; Polymorphism, Single Nucleotide; Population; Regression analysis; Risk factors; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; Womens health; United States > US; Genome wide association study; Fine mapping; Hispanic/Latino populations

Breast cancer is a partially heritable trait and genome-wide association studies (GWAS) have identified over 180 common genetic variants associated with breast cancer. We have previously performed breast cancer GWAS in Latinas and identified a strongly protective single nucleotide polymorphism (SNP)...