Hepatic angiomyolipomas with a deceptive trabecular pattern and HMB-45 reactivity

We report two cases of giant hepatic angiomyolipoma with a prominent component of epithelioid smooth muscle cells exhibiting a distinctive trabecular arrangement. These cells possessed peripherally vacuolated and centrally condensed hyaline cytoplasm. The nuclei were eccentrically placed in the cyto...

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Bibliographic Details
Published inHistopathology Vol. 21; no. 6; p. 569
Main Authors Tsui, W M, Yuen, A K, Ma, K F, Tse, C C
Format Journal Article
LanguageEnglish
Published England 01.12.1992
Subjects
Adult
Antibodies, Monoclonal
Biomarkers
Carcinoma, Hepatocellular - chemistry
Carcinoma, Hepatocellular - pathology
Diagnosis, Differential
Female
Hemangioma - chemistry
Hemangioma - pathology
Humans
Immunoenzyme Techniques
Lipoma - chemistry
Lipoma - pathology
Liver Neoplasms - chemistry
Liver Neoplasms - pathology
Middle Aged
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Summary:We report two cases of giant hepatic angiomyolipoma with a prominent component of epithelioid smooth muscle cells exhibiting a distinctive trabecular arrangement. These cells possessed peripherally vacuolated and centrally condensed hyaline cytoplasm. The nuclei were eccentrically placed in the cytoplasm. Immunohistochemically, they expressed HMB-45 intensely in the central condensed cytoplasm and actin in a perimembranous fashion. Staining for desmin, myoglobin and vimentin was negative. HMB-45 may prove to be a sensitive marker for angiomyolipoma with epithelioid cells. Hepatocellular carcinoma and other hepatic tumours with polygonal clear cells can be readily distinguished by these means.
ISSN:0309-0167
1365-2559
DOI:10.1111/j.1365-2559.1992.tb00446.x